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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1863 1
1886 1
1895 1
1897 1
1899 1
1901 2
1903 1
1909 1
1910 1
1911 3
1912 1
1914 2
1915 3
1916 2
1917 4
1918 2
1919 3
1920 2
1921 1
1922 1
1923 5
1924 3
1925 6
1926 6
1927 4
1928 5
1929 4
1930 3
1931 4
1932 3
1934 9
1935 7
1936 8
1937 12
1938 10
1939 7
1940 6
1941 8
1942 8
1943 1
1944 10
1945 45
1946 176
1947 214
1948 268
1949 173
1950 234
1951 238
1952 277
1953 334
1954 333
1955 355
1956 359
1957 383
1958 430
1959 458
1960 521
1961 618
1962 666
1963 784
1964 1136
1965 1153
1966 1249
1967 1501
1968 1758
1969 1858
1970 1971
1971 1833
1972 1721
1973 2252
1974 2527
1975 4841
1976 5319
1977 5119
1978 5448
1979 6524
1980 7546
1981 8231
1982 9322
1983 10555
1984 11439
1985 12120
1986 12434
1987 13248
1988 14404
1989 16176
1990 17766
1991 18814
1992 20316
1993 20902
1994 22476
1995 23825
1996 24438
1997 23487
1998 23004
1999 23794
2000 25911
2001 27491
2002 28174
2003 29511
2004 31344
2005 32440
2006 34207
2007 35561
2008 37041
2009 37586
2010 40219
2011 43033
2012 45855
2013 47584
2014 48876
2015 49285
2016 50008
2017 51554
2018 53078
2019 55471
2020 60522
2021 64257
2022 63281
2023 59726
2024 23596

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1,342,787 results

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An Extensive Review on beta-lactamase Enzymes and their Inhibitors.
Agarwal V, Tiwari A, Varadwaj P. Agarwal V, et al. Curr Med Chem. 2023;30(7):783-808. doi: 10.2174/0929867329666220620165429. Curr Med Chem. 2023. PMID: 35726414 Review.
beta-lactam antibiotics treat bacterial infections very effectively, but overuse and misuse have led to resistance. beta-lactamase enzymes hydrolyze beta-lactam antibiotics and are the primary cause of resistance in bacteria. ...Such mutations and structural …
beta-lactam antibiotics treat bacterial infections very effectively, but overuse and misuse have led to resistance. beta-lacta …
Progress toward inhibitors of metallo-beta-lactamases.
McGeary RP, Tan DT, Schenk G. McGeary RP, et al. Future Med Chem. 2017 May;9(7):673-691. doi: 10.4155/fmc-2017-0007. Epub 2017 May 15. Future Med Chem. 2017. PMID: 28504895 Review.
The global overuse of antibiotics has led to the emergence of drug-resistant pathogenic bacteria. Bacteria can combat beta-lactams by expressing beta-lactamases. Inhibitors of one class of beta-lactamase, the serine-beta-lactamases, are used clinically …
The global overuse of antibiotics has led to the emergence of drug-resistant pathogenic bacteria. Bacteria can combat beta-lactams by …
Structure of coiled beta-beta-hairpins and beta-beta-corners.
Efimov AV. Efimov AV. FEBS Lett. 1991 Jun 24;284(2):288-92. doi: 10.1016/0014-5793(91)80706-9. FEBS Lett. 1991. PMID: 2060653 Free article. Review.
Two types of super-secondary structure, coiled beta-beta-hairpins and beta-beta-corners, are considered in this paper. ...These unique arrangements of beta-strands in the coiled beta-beta-hairpins and beta-beta-corner …
Two types of super-secondary structure, coiled beta-beta-hairpins and beta-beta-corners, are considered in this …
Beta-lactamases and beta-lactamase inhibitors.
Williams JD. Williams JD. Int J Antimicrob Agents. 1999 Aug;12 Suppl 1:S3-7; discussion S26-7. doi: 10.1016/s0924-8579(99)00085-0. Int J Antimicrob Agents. 1999. PMID: 10526867 Review.
Resistance to beta-lactams mediated by beta-lactamases can be overcome successfully with the use of beta-lactamase inhibitors. The combination of beta-lactams with beta-lactamase inhibitors restores the activity of the beta-lactams, allow …
Resistance to beta-lactams mediated by beta-lactamases can be overcome successfully with the use of beta-lactamase inhi …
Differential activation of beta 1-, beta 2- and beta 3-adrenoceptors by catecholamines in white and brown adipocytes.
Galitzky J, Carpéné C, Bousquet-Mélou A, Berlan M, Lafontan M. Galitzky J, et al. Fundam Clin Pharmacol. 1995;9(4):324-31. doi: 10.1111/j.1472-8206.1995.tb00506.x. Fundam Clin Pharmacol. 1995. PMID: 8566931 Review.
When expressed after the transfection of their genes in Chinese hamster ovary cell (CHO cells), beta 1- and beta 2-ARs present a higher affinity for catecholamines than beta 3-ARs. ...On the other hand, the lipolytic effect of catecholamines in human and prim …
When expressed after the transfection of their genes in Chinese hamster ovary cell (CHO cells), beta 1- and beta 2-ARs present …
The 'state' of beta-adrenoceptors.
Molenaar P. Molenaar P. Br J Pharmacol. 2003 Sep;140(1):1-2. doi: 10.1038/sj.bjp.0705420. Epub 2003 Aug 4. Br J Pharmacol. 2003. PMID: 12967928 Free PMC article. Review. No abstract available.
New promising beta-lactamase inhibitors for clinical use.
Olsen I. Olsen I. Eur J Clin Microbiol Infect Dis. 2015 Jul;34(7):1303-8. doi: 10.1007/s10096-015-2375-0. Epub 2015 Apr 12. Eur J Clin Microbiol Infect Dis. 2015. PMID: 25864193 Review.
Although they have been useful as beta-lactamase inhibitors in many cases, their effectiveness is restricted to class A beta-lactamases. With the increasing frequency and breadth of beta-lactamases now threatening public health throughout the world, we need a …
Although they have been useful as beta-lactamase inhibitors in many cases, their effectiveness is restricted to class A beta-l …
Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).
Gravina SA, Ho L, Eckman CB, Long KE, Otvos L Jr, Younkin LH, Suzuki N, Younkin SG. Gravina SA, et al. J Biol Chem. 1995 Mar 31;270(13):7013-6. doi: 10.1074/jbc.270.13.7013. J Biol Chem. 1995. PMID: 7706234 Free article.
In 9 of 27 AD brains examined, there was minimal congophilic angiopathy and virtually all A beta (96%) ended at A beta 42(43). The other 18 AD brains contained increasing amounts of A beta ending at A beta 40. ...Immunocytochemical analysis with monocl …
In 9 of 27 AD brains examined, there was minimal congophilic angiopathy and virtually all A beta (96%) ended at A beta 42(43). …
The Ultrabroad-Spectrum Beta-Lactamase Inhibitor QPX7728 Restores the Potency of Multiple Oral Beta-Lactam Antibiotics against Beta-Lactamase-Producing Strains of Resistant Enterobacterales.
Lomovskaya O, Rubio-Aparicio D, Tsivkovski R, Loutit J, Dudley M. Lomovskaya O, et al. Antimicrob Agents Chemother. 2022 Feb 15;66(2):e0216821. doi: 10.1128/AAC.02168-21. Epub 2021 Dec 13. Antimicrob Agents Chemother. 2022. PMID: 34902261 Free PMC article.
QPX7728 is a cyclic boronate ultrabroad-spectrum beta-lactamase inhibitor, with potent activity against both serine beta-lactamases and metallo-beta-lactamases. ...Tebipenem and ceftibuten appeared to be the best beta-lactam antibiotics when combined w …
QPX7728 is a cyclic boronate ultrabroad-spectrum beta-lactamase inhibitor, with potent activity against both serine beta-lacta …
The human beta 3-adrenergic receptor: relationship with atypical receptors.
Emorine LJ, Fève B, Pairault J, Briend-Sutren MM, Nahmias C, Marullo S, Delavier-Klutchko C, Strosberg DA. Emorine LJ, et al. Am J Clin Nutr. 1992 Jan;55(1 Suppl):215S-218S. doi: 10.1093/ajcn/55.1.215s. Am J Clin Nutr. 1992. PMID: 1309479 Review.
Atypical beta-adrenergic receptors (beta AR), different from beta 1 and beta 2ARs, have been suggested to modulate energy expenditure. ...The beta 1 and beta 2 antagonists pindolol, oxprenolol, and CGP12177 are agonists of the beta …
Atypical beta-adrenergic receptors (beta AR), different from beta 1 and beta 2ARs, have been suggested to modula …
1,342,787 results
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