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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
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1970 57
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1973 193
1974 194
1975 180
1976 153
1977 179
1978 187
1979 164
1980 177
1981 158
1982 186
1983 173
1984 211
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1986 221
1987 239
1988 229
1989 295
1990 332
1991 304
1992 262
1993 280
1994 316
1995 311
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1997 317
1998 315
1999 341
2000 391
2001 392
2002 400
2003 410
2004 450
2005 474
2006 473
2007 514
2008 560
2009 556
2010 647
2011 689
2012 801
2013 834
2014 930
2015 1059
2016 1029
2017 1135
2018 1210
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2020 1472
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2024 656

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25,337 results

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Page 1
Therapeutic Mechanisms of Ketamine.
Mihaljević S, Pavlović M, Reiner K, Ćaćić M. Mihaljević S, et al. Psychiatr Danub. 2020 Autumn-Winter;32(3-4):325-333. doi: 10.24869/psyd.2020.325. Psychiatr Danub. 2020. PMID: 33370729 Free article. Review.
However, unique pharmacodynamic properties of ketamine have increased interests in it's use for treatment of depression. ...Acute side effects, such as increased salivation, increase in heart rate, systemic arterial pressure and intracranial pressure necessitate careful mo …
However, unique pharmacodynamic properties of ketamine have increased interests in it's use for treatment of depression. ...Acute sid …
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.
Zanos P, Moaddel R, Morris PJ, Riggs LM, Highland JN, Georgiou P, Pereira EFR, Albuquerque EX, Thomas CJ, Zarate CA Jr, Gould TD. Zanos P, et al. Pharmacol Rev. 2018 Jul;70(3):621-660. doi: 10.1124/pr.117.015198. Pharmacol Rev. 2018. PMID: 29945898 Free PMC article. Review.
Ketamine, a racemic mixture consisting of (S)- and (R)-ketamine, has been in clinical use since 1970. ...Overall, pharmacological target deconvolution of ketamine and its metabolites will provide insight critical to the development of new pharmacotherapies th …
Ketamine, a racemic mixture consisting of (S)- and (R)-ketamine, has been in clinical use since 1970. ...Overall, pharmacologi …
Oral Ketamine for Depression, 2: Practical Considerations.
Andrade C. Andrade C. J Clin Psychiatry. 2019 Apr 9;80(2):19f12838. doi: 10.4088/JCP.19f12838. J Clin Psychiatry. 2019. PMID: 30997961 Free article. Review.
The oral route of administration is probably the least expensive and most convenient way to administer ketamine in indicated contexts in depressed patients. Because only 20%-25% of orally administered ketamine reaches systemic circulation, oral doses of about 2.0-2. …
The oral route of administration is probably the least expensive and most convenient way to administer ketamine in indicated contexts …
Ketamine applications beyond anesthesia - A literature review.
Nowacka A, Borczyk M. Nowacka A, et al. Eur J Pharmacol. 2019 Oct 5;860:172547. doi: 10.1016/j.ejphar.2019.172547. Epub 2019 Jul 23. Eur J Pharmacol. 2019. PMID: 31348905 Review.
Other reports highlight the possible use of ketamine in treating addiction, asthma and preventing cancer growth. ...This review aims to discuss the well-known and new promising applications of ketamine....
Other reports highlight the possible use of ketamine in treating addiction, asthma and preventing cancer growth. ...This review aims …
Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments.
Krystal JH, Kaye AP, Jefferson S, Girgenti MJ, Wilkinson ST, Sanacora G, Esterlis I. Krystal JH, et al. Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2305772120. doi: 10.1073/pnas.2305772120. Epub 2023 Nov 27. Proc Natl Acad Sci U S A. 2023. PMID: 38011560 Free PMC article. Review.
Ketamine has emerged as a transformative and mechanistically novel pharmacotherapy for depression. ...Its discovery emerged from a reconceptualization of the neurobiology of depression and, in turn, insights from the elaboration of its mechanisms of action inform studies o …
Ketamine has emerged as a transformative and mechanistically novel pharmacotherapy for depression. ...Its discovery emerged from a re …
Ketamine for the treatment of addiction: Evidence and potential mechanisms.
Ivan Ezquerra-Romano I, Lawn W, Krupitsky E, Morgan CJA. Ivan Ezquerra-Romano I, et al. Neuropharmacology. 2018 Nov;142:72-82. doi: 10.1016/j.neuropharm.2018.01.017. Epub 2018 Jan 12. Neuropharmacology. 2018. PMID: 29339294 Review.
Moreover, ketamine reduced craving for and self-administration of cocaine in non-treatment seeking cocaine users. ...In conclusion, ketamine shows great promise as a treatment for various addictions, but well-controlled research is urgently needed. ...
Moreover, ketamine reduced craving for and self-administration of cocaine in non-treatment seeking cocaine users. ...In conclusion, …
Ketamine*.
Quibell R, Prommer EE, Mihalyo M, Twycross R, Wilcock A. Quibell R, et al. J Pain Symptom Manage. 2011 Mar;41(3):640-9. doi: 10.1016/j.jpainsymman.2011.01.001. J Pain Symptom Manage. 2011. PMID: 21419322 Free article. Review. No abstract available.
Update on Ketamine.
Zhou JY, Hamilton P, Macres S, Peña M, Tang S. Zhou JY, et al. Adv Anesth. 2020 Dec;38:97-113. doi: 10.1016/j.aan.2020.07.005. Epub 2020 Sep 14. Adv Anesth. 2020. PMID: 34106842 Review. No abstract available.
Bridging rapid and sustained antidepressant effects of ketamine.
Kim JW, Suzuki K, Kavalali ET, Monteggia LM. Kim JW, et al. Trends Mol Med. 2023 May;29(5):364-375. doi: 10.1016/j.molmed.2023.02.003. Epub 2023 Mar 10. Trends Mol Med. 2023. PMID: 36907686 Free PMC article. Review.
Acute administration of (R,S)-ketamine (ketamine) produces rapid antidepressant effects that in some patients can be sustained for several days to more than a week. Ketamine blocks N-methyl-d-asparate (NMDA) receptors (NMDARs) to elicit specific downstream si …
Acute administration of (R,S)-ketamine (ketamine) produces rapid antidepressant effects that in some patients can be sustained …
Ketamine inhalation.
Jonkman K, Duma A, Velzen M, Dahan A. Jonkman K, et al. Br J Anaesth. 2017 Feb;118(2):268-269. doi: 10.1093/bja/aew457. Br J Anaesth. 2017. PMID: 28100533 Free article. No abstract available.
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