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Showing results for petasin
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Petasin is the main component responsible for the anti-adipogenic effect of Petasites japonicus.
Uesugi S, Hakozaki M, Kanno Y, Shiraishi A, Suzuki M, Kimura KI, Shiono Y, Yano A. Uesugi S, et al. Fitoterapia. 2022 Mar;157:105130. doi: 10.1016/j.fitote.2022.105130. Epub 2022 Jan 18. Fitoterapia. 2022. PMID: 35051554
Quantitative analysis revealed that the active component responsible for most of the anti-adipogenic effects of P. japonicus extract is petasin. Petasin suppressed the expression of markers of mature adipocytes (PPARgamma, C/EBPalpha, and aP2). ...These findings ind …
Quantitative analysis revealed that the active component responsible for most of the anti-adipogenic effects of P. japonicus extract is p …
S-petasin inhibits lipid accumulation in oleic acid-induced HepG2 cells through activation of the AMPK signaling pathway.
Guo L, Kang JS, Park YH, Je BI, Lee YJ, Kang NJ, Park SY, Hwang DY, Choi YW. Guo L, et al. Food Funct. 2020 Jun 24;11(6):5664-5673. doi: 10.1039/d0fo00594k. Food Funct. 2020. PMID: 32542253
Moreover, results showed that the triacylglycerol level was reduced by s-petasin in oleic acid-induced HepG2 cells. Western blot assay revealed that s-petasin stimulated phosphorylation of AMPKalpha and ACCalpha. ...This in vitro study indicates that s-petasin …
Moreover, results showed that the triacylglycerol level was reduced by s-petasin in oleic acid-induced HepG2 cells. Western blot assa …
S-Petasin isolated from Petasites japonicus exerts anti-adipogenic activity in the 3T3-L1 cell line by inhibiting PPAR-gamma pathway signaling.
Guo L , Li K , Cui ZW , Kang JS , Son BG , Choi YW . Guo L , et al. Food Funct. 2019 Jul 17;10(7):4396-4406. doi: 10.1039/c9fo00549h. Food Funct. 2019. PMID: 31282906
The results showed that s-petasin presented strong anti-adipogenic activity. Further studies illustrated that s-petasin reduced glucose uptake. Moreover, results showed that triglyceride accumulation was inhibited by s-petasin in differentiated 3T3-L1 cells. …
The results showed that s-petasin presented strong anti-adipogenic activity. Further studies illustrated that s-petasin reduce …
S-petasin induces apoptosis and inhibits cell migration through activation of p53 pathway signaling in melanoma B16F10 cells and A375 cells.
Guo L, Kang JS, Kang NJ, Choi YW. Guo L, et al. Arch Biochem Biophys. 2020 Oct 15;692:108519. doi: 10.1016/j.abb.2020.108519. Epub 2020 Aug 4. Arch Biochem Biophys. 2020. PMID: 32763235
However, no studies have reported that s-petasin exerted anti-melanoma or inhibited activity in melanoma cells. ...For mechanism study, western blot assay indicated that s-petasin activated the p53 pathway signaling. Furthermore, expression of Bcl-2, Bcl-(X)L, Bax, …
However, no studies have reported that s-petasin exerted anti-melanoma or inhibited activity in melanoma cells. ...For mechanism stud …
Petasin potently inhibits mitochondrial complex I-based metabolism that supports tumor growth and metastasis.
Heishima K, Sugito N, Soga T, Nishikawa M, Ito Y, Honda R, Kuranaga Y, Sakai H, Ito R, Nakagawa T, Ueda H, Akao Y. Heishima K, et al. J Clin Invest. 2021 Sep 1;131(17):e139933. doi: 10.1172/JCI139933. J Clin Invest. 2021. PMID: 34623325 Free PMC article.
Mitochondrial electron transport chain complex I (ETCC1) is the essential core of cancer metabolism, yet potent ETCC1 inhibitors capable of safely suppressing tumor growth and metastasis in vivo are limited. From a plant extract screening, we identified petasin (PT) as a h …
Mitochondrial electron transport chain complex I (ETCC1) is the essential core of cancer metabolism, yet potent ETCC1 inhibitors capable of …
A novel petasin-modified zinc oxide eugenol sealer.
Vinola SMJ, Karthikeyan K, Mahalaxmi S. Vinola SMJ, et al. J Conserv Dent. 2019 Sep-Oct;22(5):490-494. doi: 10.4103/JCD.JCD_475_19. Epub 2020 Aug 4. J Conserv Dent. 2019. PMID: 33082668 Free PMC article.
The scope of this study was to investigate the setting time, solubility, cytotoxic effects, and anti-inflammatory action of ZOE sealer with the modification of its liquid component by the addition of petasin extract in the ratios 1:1, 5:1, and 10:1. MATERIALS AND METHODS: …
The scope of this study was to investigate the setting time, solubility, cytotoxic effects, and anti-inflammatory action of ZOE sealer with …
Petasin and isopetasin reduce CGRP release from trigeminal afferents indicating an inhibitory effect on TRPA1 and TRPV1 receptor channels.
Kleeberg-Hartmann J, Vogler B, Messlinger K. Kleeberg-Hartmann J, et al. J Headache Pain. 2021 Apr 13;22(1):23. doi: 10.1186/s10194-021-01235-5. J Headache Pain. 2021. PMID: 33849430 Free PMC article.
BACKGROUND: Butterbur root extract with its active ingredients petasin and isopetasin has been used in the prophylactic treatment of migraine for years, while its sites of action are not completely clear. ...These mechanisms may contribute to the migraine prophylactic effe …
BACKGROUND: Butterbur root extract with its active ingredients petasin and isopetasin has been used in the prophylactic treatment of …
Therapeutic effects of s-petasin on disease models of asthma and peritonitis.
Lee KP, Kang S, Noh MS, Park SJ, Kim JM, Chung HY, Je NK, Lee YG, Choi YW, Im DS. Lee KP, et al. Biomol Ther (Seoul). 2015 Jan;23(1):45-52. doi: 10.4062/biomolther.2014.069. Epub 2015 Jan 1. Biomol Ther (Seoul). 2015. PMID: 25593643 Free PMC article.
S-petasin inhibited the LPS induction of iNOS at the RNA and protein levels in mouse peritoneal macrophages. Furthermore, s-petasin inhibited the production of NO (the product of iNOS) in a concentration-dependent manner in the macrophages. ...
S-petasin inhibited the LPS induction of iNOS at the RNA and protein levels in mouse peritoneal macrophages. Furthermore, s-petasi …
Anti-inflammatory efficacy of petasin-incorporated zinc oxide eugenol sealer - An in vivo zebrafish study.
Vinola SMJ, Karthikeyan K, Sharma A, Sudheshna S, Sekar M. Vinola SMJ, et al. J Conserv Dent. 2021 Nov-Dec;24(6):539-543. doi: 10.4103/jcd.jcd_433_21. Epub 2022 Apr 1. J Conserv Dent. 2021. PMID: 35558677 Free PMC article.
The samples (n = 50) were divided into five groups (n = 10) - Group 1: incision only (negative control), Group 2: zinc oxide (ZnO) (positive control), Group 3: ZnO + eugenol and petasin in ratio of 10:1, Group 4: ZnO + eugenol and petasin in ratio of 5:1, and Group …
The samples (n = 50) were divided into five groups (n = 10) - Group 1: incision only (negative control), Group 2: zinc oxide (ZnO) (positive …
Inhibitory effects of petasin on human colon carcinoma cells mediated by inactivation of Akt/mTOR pathway.
Lyu X, Song AL, Bai YL, Xu XD, He DQ, Zhang YC. Lyu X, et al. Chin Med J (Engl). 2019 May 5;132(9):1071-1078. doi: 10.1097/CM9.0000000000000199. Chin Med J (Engl). 2019. PMID: 30896562 Free PMC article.
The present study aimed to investigate the anticolon cancer activity of petasin both in vitro and in vivo. The molecular mechanism of petasin was also further explored. ...Our findings suggest petasin as a potential candidate for colon cancer therapy....
The present study aimed to investigate the anticolon cancer activity of petasin both in vitro and in vivo. The molecular mechanism of …
61 results