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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 2
2006 3
2007 1
2008 3
2009 3
2010 2
2012 1
2013 2
2015 1
2017 1
2018 1
2019 3
2020 1
2021 3
2022 1
2024 0

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26 results

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Page 1
Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19.
Kuba K, Yamaguchi T, Penninger JM. Kuba K, et al. Front Immunol. 2021 Dec 22;12:732690. doi: 10.3389/fimmu.2021.732690. eCollection 2021. Front Immunol. 2021. PMID: 35003058 Free PMC article. Review.
Soluble forms of recombinant ACE2 are currently utilized as a pan-variant decoy to neutralize SARS-CoV-2 and a supplementation of ACE2 carboxypeptidase activity. Here, we review the role of ACE2 in the pathology of ARDS in COVID-19 and the potential applicati …
Soluble forms of recombinant ACE2 are currently utilized as a pan-variant decoy to neutralize SARS-CoV-2 and a supplementation of …
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury.
Yamaguchi T, Hoshizaki M, Minato T, Nirasawa S, Asaka MN, Niiyama M, Imai M, Uda A, Chan JF, Takahashi S, An J, Saku A, Nukiwa R, Utsumi D, Kiso M, Yasuhara A, Poon VK, Chan CC, Fujino Y, Motoyama S, Nagata S, Penninger JM, Kamada H, Yuen KY, Kamitani W, Maeda K, Kawaoka Y, Yasutomi Y, Imai Y, Kuba K. Yamaguchi T, et al. Nat Commun. 2021 Nov 23;12(1):6791. doi: 10.1038/s41467-021-27097-8. Nat Commun. 2021. PMID: 34815389 Free PMC article.
Angiotensin-converting enzyme 2 (ACE2) is a receptor for cell entry of SARS-CoV-2, and recombinant soluble ACE2 protein inhibits SARS-CoV-2 infection as a decoy. ...Here we show that B38-CAP, an ACE2-like enzyme, is protective against SARS-CoV-2-induced lung …
Angiotensin-converting enzyme 2 (ACE2) is a receptor for cell entry of SARS-CoV-2, and recombinant soluble ACE2 protein inhibi …
ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury.
Minato T, Yamaguchi T, Hoshizaki M, Nirasawa S, An J, Takahashi S, Penninger JM, Imai Y, Kuba K. Minato T, et al. PLoS One. 2022 Jul 22;17(7):e0270920. doi: 10.1371/journal.pone.0270920. eCollection 2022. PLoS One. 2022. PMID: 35867642 Free PMC article.
B38-CAP is a bacteria-derived ACE2-like carboxypeptidase as potent as human ACE2 and ameliorates hypertension, heart failure and SARS-CoV-2-induced lung injury in mice. ...ACE2 expression was downregulated in the lungs of mice with cecal ligation puncture (CL …
B38-CAP is a bacteria-derived ACE2-like carboxypeptidase as potent as human ACE2 and ameliorates hypertension, heart failure a …
Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis.
Imai Y, Kuba K, Ohto-Nakanishi T, Penninger JM. Imai Y, et al. Circ J. 2010 Mar;74(3):405-10. doi: 10.1253/circj.cj-10-0045. Epub 2010 Feb 4. Circ J. 2010. PMID: 20134095 Free article. Review.
Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and disc …
Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 …
Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters.
Kuba K, Imai Y, Ohto-Nakanishi T, Penninger JM. Kuba K, et al. Pharmacol Ther. 2010 Oct;128(1):119-28. doi: 10.1016/j.pharmthera.2010.06.003. Epub 2010 Jul 3. Pharmacol Ther. 2010. PMID: 20599443 Free PMC article. Review.
Downregulation of ACE2 strongly contributes to the pathogenesis of severe lung failure. ...In this review, we will discuss the multiple biological functions of ACE2....
Downregulation of ACE2 strongly contributes to the pathogenesis of severe lung failure. ...In this review, we will discuss the multip …
B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction.
Minato T, Nirasawa S, Sato T, Yamaguchi T, Hoshizaki M, Inagaki T, Nakahara K, Yoshihashi T, Ozawa R, Yokota S, Natsui M, Koyota S, Yoshiya T, Yoshizawa-Kumagaye K, Motoyama S, Gotoh T, Nakaoka Y, Penninger JM, Watanabe H, Imai Y, Takahashi S, Kuba K. Minato T, et al. Nat Commun. 2020 Feb 26;11(1):1058. doi: 10.1038/s41467-020-14867-z. Nat Commun. 2020. PMID: 32103002 Free PMC article.
Here we show that the B38-CAP, a carboxypeptidase derived from Paenibacillus sp. B38, is an ACE2-like enzyme to decrease angiotensin II levels in mice. In protein 3D structure analysis, B38-CAP homolog shares structural similarity to mammalian ACE2 with low sequence …
Here we show that the B38-CAP, a carboxypeptidase derived from Paenibacillus sp. B38, is an ACE2-like enzyme to decrease angiotensin …
Apelin is a positive regulator of ACE2 in failing hearts.
Sato T, Suzuki T, Watanabe H, Kadowaki A, Fukamizu A, Liu PP, Kimura A, Ito H, Penninger JM, Imai Y, Kuba K. Sato T, et al. J Clin Invest. 2013 Dec;123(12):5203-11. doi: 10.1172/JCI69608. Epub 2013 Nov 1. J Clin Invest. 2013. PMID: 24177423 Free PMC article.
Moreover, apelin, via activation of its receptor, APJ, increased ACE2 promoter activity in vitro and upregulated ACE2 expression in failing hearts in vivo. Apelin treatment also increased cardiac contractility and ACE2 levels in AT1R-deficient mice. These dat …
Moreover, apelin, via activation of its receptor, APJ, increased ACE2 promoter activity in vitro and upregulated ACE2 expressi …
Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases.
Kuba K, Imai Y, Penninger JM. Kuba K, et al. Circ J. 2013;77(2):301-8. doi: 10.1253/circj.cj-12-1544. Epub 2013 Jan 18. Circ J. 2013. PMID: 23328447 Free article. Review.
ACE2 catalyzes the conversion of angiotensin II to angiotensin 1-7, thereby counterbalancing ACE activity. Accumulating evidence indicates that the enzymatic activity of ACE2 has a protective role in cardiovascular diseases. Loss of ACE2 can be detrimental, a …
ACE2 catalyzes the conversion of angiotensin II to angiotensin 1-7, thereby counterbalancing ACE activity. Accumulating evidence indi …
Angiotensin-converting enzyme 2 in acute respiratory distress syndrome.
Imai Y, Kuba K, Penninger JM. Imai Y, et al. Cell Mol Life Sci. 2007 Aug;64(15):2006-12. doi: 10.1007/s00018-007-6228-6. Cell Mol Life Sci. 2007. PMID: 17558469 Free PMC article. Review.
ACE cleaves angiotensin I to generate angiotensin II, whereas ACE2 reduces angiotensin II levels. Accumulating evidence has demonstrated a physiological and pathological role of ACE2 in the cardiovascular systems. ...Moreover, recent studies have demonstrated that …
ACE cleaves angiotensin I to generate angiotensin II, whereas ACE2 reduces angiotensin II levels. Accumulating evidence has demonstra …
26 results