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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1852 2
1930 1
1931 1
1934 1
1949 1
1950 3
1951 2
1952 1
1953 2
1954 2
1955 4
1956 5
1957 4
1958 3
1959 9
1960 17
1961 15
1962 38
1963 81
1964 101
1965 105
1966 130
1967 166
1968 138
1969 153
1970 160
1971 154
1972 171
1973 138
1974 144
1975 143
1976 131
1977 135
1978 108
1979 129
1980 143
1981 137
1982 112
1983 152
1984 187
1985 175
1986 194
1987 154
1988 169
1989 184
1990 176
1991 207
1992 177
1993 234
1994 241
1995 206
1996 228
1997 243
1998 241
1999 230
2000 270
2001 270
2002 291
2003 317
2004 325
2005 408
2006 409
2007 511
2008 528
2009 569
2010 675
2011 773
2012 891
2013 988
2014 1182
2015 1332
2016 1420
2017 1468
2018 1524
2019 1638
2020 1965
2021 2050
2022 1934
2023 1979
2024 989

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28,053 results

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Page 1
Lactate, histone lactylation and cancer hallmarks.
Lv X, Lv Y, Dai X. Lv X, et al. Expert Rev Mol Med. 2023 Jan 9;25:e7. doi: 10.1017/erm.2022.42. Expert Rev Mol Med. 2023. PMID: 36621008 Review.
Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation …
Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a n …
Targeting lactate-related cell cycle activities for cancer therapy.
Lin J, Liu G, Chen L, Kwok HF, Lin Y. Lin J, et al. Semin Cancer Biol. 2022 Nov;86(Pt 3):1231-1243. doi: 10.1016/j.semcancer.2022.10.009. Epub 2022 Oct 31. Semin Cancer Biol. 2022. PMID: 36328311 Review.
Lactate has long been considered as a metabolic by-product of aerobic glycolysis for cancer. ...A recent discovery of lactylation attracted a lot of attention and is already a hot topic in the cancer field. In this review, we summarized the latest functions o …
Lactate has long been considered as a metabolic by-product of aerobic glycolysis for cancer. ...A recent discovery of lactylat …
Lactate-induced protein lactylation: A bridge between epigenetics and metabolic reprogramming in cancer.
Wang T, Ye Z, Li Z, Jing DS, Fan GX, Liu MQ, Zhuo QF, Ji SR, Yu XJ, Xu XW, Qin Y. Wang T, et al. Cell Prolif. 2023 Oct;56(10):e13478. doi: 10.1111/cpr.13478. Epub 2023 Apr 14. Cell Prolif. 2023. PMID: 37060186 Free PMC article. Review.
Lactate is not only an endpoint of glycolysis but is gradually being discovered to play the role of a universal metabolic fuel for energy via the 'lactate shuttle' moving between cells and transmitting signals. ...Moreover, lactate can provide favourable cond …
Lactate is not only an endpoint of glycolysis but is gradually being discovered to play the role of a universal metabolic fuel for en …
Lactate metabolism in human health and disease.
Li X, Yang Y, Zhang B, Lin X, Fu X, An Y, Zou Y, Wang JX, Wang Z, Yu T. Li X, et al. Signal Transduct Target Ther. 2022 Sep 1;7(1):305. doi: 10.1038/s41392-022-01151-3. Signal Transduct Target Ther. 2022. PMID: 36050306 Free PMC article. Review.
The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells, organs and tissues. ...This review offers a systematic overview of lactate homeostasis and its role …
The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates …
PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy.
Dou X, Fu Q, Long Q, Liu S, Zou Y, Fu D, Xu Q, Jiang Z, Ren X, Zhang G, Wei X, Li Q, Campisi J, Zhao Y, Sun Y. Dou X, et al. Nat Metab. 2023 Nov;5(11):1887-1910. doi: 10.1038/s42255-023-00912-w. Epub 2023 Oct 30. Nat Metab. 2023. PMID: 37903887 Free PMC article.
Medium from PDK4(+) stromal cells promotes the malignancy of recipient cancer cells in vitro, whereas inhibition of PDK4 causes tumor regression in vivo. ...Together, our study confirms the hypercatabolic nature of senescent cells and reveals a metabolic link between cellu …
Medium from PDK4(+) stromal cells promotes the malignancy of recipient cancer cells in vitro, whereas inhibition of PDK4 causes tumor …
Lactate-Lactylation Hands between Metabolic Reprogramming and Immunosuppression.
Chen L, Huang L, Gu Y, Cang W, Sun P, Xiang Y. Chen L, et al. Int J Mol Sci. 2022 Oct 8;23(19):11943. doi: 10.3390/ijms231911943. Int J Mol Sci. 2022. PMID: 36233246 Free PMC article. Review.
Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer. Interestingly, lactate closely links them together. However, lactate has long been recognized as a metabolic waste product. ...We explored the possibility of targeting potenti …
Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer. Interestingly, lactate closely links them …
Lactate Rewires Lipid Metabolism and Sustains a Metabolic-Epigenetic Axis in Prostate Cancer.
Ippolito L, Comito G, Parri M, Iozzo M, Duatti A, Virgilio F, Lorito N, Bacci M, Pardella E, Sandrini G, Bianchini F, Damiano R, Ferrone L, la Marca G, Serni S, Spatafora P, Catapano CV, Morandi A, Giannoni E, Chiarugi P. Ippolito L, et al. Cancer Res. 2022 Apr 1;82(7):1267-1282. doi: 10.1158/0008-5472.CAN-21-0914. Cancer Res. 2022. PMID: 35135811 Free PMC article.
Lactate is an abundant oncometabolite in the tumor environment. In prostate cancer, cancer-associated fibroblasts (CAF) are major contributors of secreted lactate, which can be taken up by cancer cells to sustain mitochondrial metabolism. ...Cli …
Lactate is an abundant oncometabolite in the tumor environment. In prostate cancer, cancer-associated fibroblasts (CAF) …
Engineering lactate-modulating nanomedicines for cancer therapy.
Chen J, Zhu Y, Wu C, Shi J. Chen J, et al. Chem Soc Rev. 2023 Feb 6;52(3):973-1000. doi: 10.1039/d2cs00479h. Chem Soc Rev. 2023. PMID: 36597879 Review.
In recent years, lactate modulation nanomedicines have emerged as a charming and efficient strategy for fighting cancer, which play important roles in optimizing the delivery of lactate-modulating agents for more precise and effective modulation and treatment …
In recent years, lactate modulation nanomedicines have emerged as a charming and efficient strategy for fighting cancer, which …
Lactate/GPR81 signaling and proton motive force in cancer: Role in angiogenesis, immune escape, nutrition, and Warburg phenomenon.
Brown TP, Ganapathy V. Brown TP, et al. Pharmacol Ther. 2020 Feb;206:107451. doi: 10.1016/j.pharmthera.2019.107451. Epub 2019 Dec 10. Pharmacol Ther. 2020. PMID: 31836453 Review.
Reprogramming of biochemical pathways is a hallmark of cancer cells, and generation of lactic acid from glucose/glutamine represents one of the consequences of such metabolic alterations. Cancer cells export lactic acid out to prevent int …
Reprogramming of biochemical pathways is a hallmark of cancer cells, and generation of lactic acid from glucose/glutami …
Lactate-related metabolic reprogramming and immune regulation in colorectal cancer.
Sun Q, Wu J, Zhu G, Li T, Zhu X, Ni B, Xu B, Ma X, Li J. Sun Q, et al. Front Endocrinol (Lausanne). 2023 Jan 26;13:1089918. doi: 10.3389/fendo.2022.1089918. eCollection 2022. Front Endocrinol (Lausanne). 2023. PMID: 36778600 Free PMC article. Review.
Hypoxic and acidified tumor microenvironment contributes mainly to the production of glycolytic products known as lactate. Mounting evidence suggests that lactate in the tumor microenvironment of colorectal cancer(CRC) contributes to cancer therapeutic …
Hypoxic and acidified tumor microenvironment contributes mainly to the production of glycolytic products known as lactate. Mounting e …
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