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Page 1
Analysis of Electrophysiological Mechanisms of N-Deacetyllapaconitine Monochlorhydrate, the Main Metabolite of Lappaconitine Hydrobromide.
Tsorin IB, Teplov IY, Zinchenko VP, Vititnova MB, Tsyrlina EM, Yunusov MS, Kryzhanovskii SA. Tsorin IB, et al. Bull Exp Biol Med. 2022 Jun;173(2):219-223. doi: 10.1007/s10517-022-05522-2. Epub 2022 Jun 24. Bull Exp Biol Med. 2022. PMID: 35739330
In in vitro experiments on isolated rat hippocampal neurons, we studied the electrophysiological mechanisms of the antiarrhythmic effects of N-deacetyllappaconitine monochlorhydrate (DALCh), active metabolite of lappaconitine hydrobromide (allapinin). Electrical act …
In in vitro experiments on isolated rat hippocampal neurons, we studied the electrophysiological mechanisms of the antiarrhythmic effects of …
A Metabolomic Study of the Analgesic Effect of Lappaconitine Hydrobromide (LAH) on Inflammatory Pain.
Li X, Wang X, Li Z, Mao Y, Liu Z, Liu X, Zhu X, Zhang J. Li X, et al. Metabolites. 2022 Sep 29;12(10):923. doi: 10.3390/metabo12100923. Metabolites. 2022. PMID: 36295824 Free PMC article.
Lappaconitine (LA) is a C-18 diterpene alkaloid isolated from Aconitum sinomontanum Nakai that has been shown to relieve mild to moderate discomfort. ...This article uses metabolomics technology to investigate the metabolite alterations in the dorsal root ganglion (DRG) wh …
Lappaconitine (LA) is a C-18 diterpene alkaloid isolated from Aconitum sinomontanum Nakai that has been shown to relieve mild to mode …
Lappaconitine trifluoroacetate contained polyvinyl alcohol nanofibrous membranes: Characterization, biological activities and transdermal application.
Teng G, Zhang X, Zhang C, Chen L, Sun W, Qiu T, Zhang J. Teng G, et al. Mater Sci Eng C Mater Biol Appl. 2020 Mar;108:110515. doi: 10.1016/j.msec.2019.110515. Epub 2019 Dec 3. Mater Sci Eng C Mater Biol Appl. 2020. PMID: 31924037
Lappaconitine (LA), a potent analgesic drug extracted from the root of natural aconitum species, has been clinically used for years because of its effectiveness and non-addictive properties. However, it is mainly limited in oral and intravenous administration in the form o …
Lappaconitine (LA), a potent analgesic drug extracted from the root of natural aconitum species, has been clinically used for years b …
Quantitative Electrophysiological Evaluation of the Analgesic Efficacy of Two Lappaconitine Derivatives: A Window into Antinociceptive Drug Mechanisms.
Teng G, Zhang F, Li Z, Zhang C, Zhang L, Chen L, Zhou T, Yue L, Zhang J. Teng G, et al. Neurosci Bull. 2021 Nov;37(11):1555-1569. doi: 10.1007/s12264-021-00774-w. Epub 2021 Sep 22. Neurosci Bull. 2021. PMID: 34550562 Free PMC article.
Quantitative evaluation of analgesic efficacy improves understanding of the antinociceptive mechanisms of new analgesics and provides important guidance for their development. Lappaconitine (LA), a potent analgesic drug extracted from the root of natural Aconitum species, …
Quantitative evaluation of analgesic efficacy improves understanding of the antinociceptive mechanisms of new analgesics and provides import …
Pharmacokinetic study of lappaconitine hydrobromide in mice by LC-MS.
Wang Q, Li ZJ, Sun L, Gao LY, Li MH, Hao JJ, Zhang X, Sun YM. Wang Q, et al. Yao Xue Xue Bao. 2011 Apr;46(4):432-7. Yao Xue Xue Bao. 2011. PMID: 21748973
Intra- and inter-run precisions (RSD) were both less than 9.9% and accuracy (RE) within +/- 4.8%. After single intravenous injections of lappaconitine hydrobromide at 1.0, 2.0 and 4.0 mg x kg(-1), the elimination half-lives (t(1/2)) were 0.47, 0.48 and 0.49 h, and t …
Intra- and inter-run precisions (RSD) were both less than 9.9% and accuracy (RE) within +/- 4.8%. After single intravenous injections of …
Simultaneous determination of lappaconitine hydrobromide and isopropiram fumarate in rabbit plasma by capillary electrophoresis with electrochemiluminescence detection.
Zhou M, Li Y, Liu C, Ma Y, Mi J, Wang S. Zhou M, et al. Electrophoresis. 2012 Aug;33(16):2577-83. doi: 10.1002/elps.201100630. Electrophoresis. 2012. PMID: 22899266
A CE electrochemiluminescence (CE-ECL) method for simultaneous determination of lappaconitine hydrobromide (LH) and isopropiram fumarate (IF) has been first established, with a chemically modified platinum electrode by europium (III)-doped Prussian blue analogue fil …
A CE electrochemiluminescence (CE-ECL) method for simultaneous determination of lappaconitine hydrobromide (LH) and isopropira …
X-ray structure analysis of lappaconitine.
Sun W, Wang Y, Zhang J, Yu K. Sun W, et al. Nat Prod Res. 2009;23(10):960-2. doi: 10.1080/14786410902975616. Nat Prod Res. 2009. PMID: 19521910
Lappaconitine is an important alkaloid of the aconite family and its biological activity is closely related to its structure. Through an X-ray structure analysis of hydrated lappaconitine hydrobromide, which was synthesised by us through a new method, the abs …
Lappaconitine is an important alkaloid of the aconite family and its biological activity is closely related to its structure. Through …
Complexation of lappaconitine with glycyrrhizic acid: stability and reactivity studies.
Polyakov NE, Khan VK, Taraban MB, Leshina TV, Salakhutdinov NF, Tolstikov GA. Polyakov NE, et al. J Phys Chem B. 2005 Dec 29;109(51):24526-30. doi: 10.1021/jp053434v. J Phys Chem B. 2005. PMID: 16375457
In MeOH, DMSO, or aqueous solutions, lappaconitine has been shown to form a stable complex with glycyrrhizic acid with 1:1 stoichiometry over a broad concentration range from 1 microM to 300 microM. The stability constant K(11) equals 2.0 x 10(5) M(-1) in aqueous solution. …
In MeOH, DMSO, or aqueous solutions, lappaconitine has been shown to form a stable complex with glycyrrhizic acid with 1:1 stoichiome …
Studies on the metabolism of lappaconitine in humans. Identification of the metabolites of lappaconitine in human urine by high performance liquid chromatography.
Xie FM, Wang HC, Li JH, Shu HL, Jiang JR, Chang JP, Hsieh YY. Xie FM, et al. Biomed Chromatogr. 1990 Jan;4(1):43-6. doi: 10.1002/bmc.1130040108. Biomed Chromatogr. 1990. PMID: 2310842
The metabolites of lappaconitine in the urine of humans having been previously administered intramuscularly with lappaconitine hydrobromide were studied using high performance liquid chromatography with electrochemical and ultraviolet detection. ...It was pro …
The metabolites of lappaconitine in the urine of humans having been previously administered intramuscularly with lappaconitine …
Lappaconitine-loaded microspheres for parenteral sustained release: effects of formulation variables and in vitro characterization.
Xu H, Zhong H, Liu M, Xu C, Gao Y. Xu H, et al. Pharmazie. 2011 Sep;66(9):654-61. Pharmazie. 2011. PMID: 22026119
Lappaconitine instead of its hydrobromide salts has been encapsulated in poly (lactide-co-glycolide) acid (PLGA) microspheres by the simple o/w emulsion solvent evaporation technique. ...The results of DSC, FT-IR study reveal no interaction between drug and polymer. …
Lappaconitine instead of its hydrobromide salts has been encapsulated in poly (lactide-co-glycolide) acid (PLGA) microspheres …
18 results