Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2016 1
2019 1
2020 1
2021 1
2022 2
2023 3
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

9 results

Results by year

Filters applied: . Clear all
Page 1
Showing results for lenalidomide native
Your search for lenalidomide-nativ retrieved no results
Lenalidomide Stabilizes Protein-Protein Complexes by Turning Labile Intermolecular H-Bonds into Robust Interactions.
Miñarro-Lleonar M, Bertran-Mostazo A, Duro J, Barril X, Juárez-Jiménez J. Miñarro-Lleonar M, et al. J Med Chem. 2023 May 11;66(9):6037-6046. doi: 10.1021/acs.jmedchem.2c01692. Epub 2023 Apr 21. J Med Chem. 2023. PMID: 37083375 Free PMC article.
Targeted protein degradation is a promising therapeutic strategy, spearheaded by the anti-myeloma drugs lenalidomide and pomalidomide. These drugs stabilize very efficiently the complex between the E3 ligase Cereblon (CRBN) and several non-native client proteins (ne …
Targeted protein degradation is a promising therapeutic strategy, spearheaded by the anti-myeloma drugs lenalidomide and pomalidomide …
Synthesis and Preliminary Characterization of Putative Anle138b-Centered PROTACs against α-Synuclein Aggregation.
Pedrini M, Iannielli A, Meneghelli L, Passarella D, Broccoli V, Seneci P. Pedrini M, et al. Pharmaceutics. 2023 May 11;15(5):1467. doi: 10.3390/pharmaceutics15051467. Pharmaceutics. 2023. PMID: 37242709 Free PMC article.
The search for disease-modifying agents targeted against Parkinson's disease led us to rationally design a small array of six Anle138b-centered PROTACs, 7a,b, 8a,b and 9a,b, targeting alphaSynuclein (alphaSyn) aggregates for binding, polyubiquitination by the E3 ligase Cereblon ( …
The search for disease-modifying agents targeted against Parkinson's disease led us to rationally design a small array of six Anle138b-cente …
Ligand Enabled Pd(II)-Catalyzed gamma-C(sp(3))-H Lactamization of Native Amides.
Liu S, Zhuang Z, Qiao JX, Yeung KS, Su S, Cherney EC, Ruan Z, Ewing WR, Poss MA, Yu JQ. Liu S, et al. J Am Chem Soc. 2021 Dec 29;143(51):21657-21666. doi: 10.1021/jacs.1c10183. Epub 2021 Dec 16. J Am Chem Soc. 2021. PMID: 34914877 Free PMC article.
Herein we report a novel 2-pyridone ligand enabled Pd(II)-catalyzed gamma-C(sp(3))-H lactamization of amino acid derived native amides, providing the convenient synthesis of gamma-lactams, isoindolinones, and 2-imidazolidinones. ...The utility of this protocol was demonstr …
Herein we report a novel 2-pyridone ligand enabled Pd(II)-catalyzed gamma-C(sp(3))-H lactamization of amino acid derived native amide …
Native mass spectrometry of complexes formed by molecular glues reveals stoichiometric rearrangement of E3 ligases.
Jackson C, Beveridge R. Jackson C, et al. Analyst. 2024 Apr 19. doi: 10.1039/d4an00110a. Online ahead of print. Analyst. 2024. PMID: 38639441
In this application of native mass spectrometry (nMS) to investigate complexes formed by molecular glues (MGs), we have demonstrated its efficiency in delineating stoichiometric rearrangements of E3 ligases that occur during targeted protein degradation (TPD). ...We have s …
In this application of native mass spectrometry (nMS) to investigate complexes formed by molecular glues (MGs), we have demonstrated …
Efficacy and Safety Analysis of VRD-PDCE in Treatment-Native Patients with Multiple Extramedullary Plasmacytomas or Plasma Cell Leukemia.
Zhao W, Chen L, Wang L, Wang W. Zhao W, et al. Indian J Hematol Blood Transfus. 2023 Jul;39(3):383-391. doi: 10.1007/s12288-022-01610-5. Epub 2022 Dec 8. Indian J Hematol Blood Transfus. 2023. PMID: 37304491
An intensive chemotherapy treatment as VRD-PDCE consisted of bortezomib, lenalidomide, dexamethasone plus cisplatin, pegylated liposomal doxorubicin, cyclophosphamide and etoposide was first proposed. ...
An intensive chemotherapy treatment as VRD-PDCE consisted of bortezomib, lenalidomide, dexamethasone plus cisplatin, pegylated liposo …
CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy.
Fu SJ, Hu MC, Peng YJ, Fang HY, Hsiao CT, Chen TY, Jeng CJ, Tang CY. Fu SJ, et al. Cells. 2020 May 26;9(6):1332. doi: 10.3390/cells9061332. Cells. 2020. PMID: 32466489 Free PMC article.
The cullin 4 (CUL4)-damage-specific DNA binding protein 1 (DDB1)-cereblon (CRBN) E3 ubiquitin ligase co-exists in the same complex with and promotes the degradation of ClC-2 channels. The CRBN-targeting immunomodulatory drug lenalidomide and the cullin E3 ligase inhibitor …
The cullin 4 (CUL4)-damage-specific DNA binding protein 1 (DDB1)-cereblon (CRBN) E3 ubiquitin ligase co-exists in the same complex with and …
Assessing the treatment effect of daratumumab by serial measurements of cardiac biomarkers and imaging parameters in light-chain cardiac amyloidosis.
Tokai T, Takashio S, Kawano Y, Kidoh M, Oda S, Matsuoka M, Tsujita K. Tokai T, et al. J Cardiol Cases. 2022 Jul 16;26(4):301-304. doi: 10.1016/j.jccase.2022.06.008. eCollection 2022 Oct. J Cardiol Cases. 2022. PMID: 36187319 Free PMC article.
Herein, we report two cases of AL cardiac amyloidosis with MM who were treated with daratumumab, lenalidomide, and dexamethasone (DRd). Serial evaluation of cardiac biomarkers, echocardiography, and cardiac magnetic resonance imaging (CMR) were performed during 12 months o …
Herein, we report two cases of AL cardiac amyloidosis with MM who were treated with daratumumab, lenalidomide, and dexamethasone (DRd …
POEMS Syndrome Showing Left Ventricular Dysfunction and Extracellular Edema Assessed by Cardiac Magnetic Resonance Imaging.
Takahashi Y, Iwano H, Nakano I, Fukushima A, Naya M, Shimizu A, Matsuno Y, Oyama-Manabe N, Anzai T. Takahashi Y, et al. Intern Med. 2019 Sep 1;58(17):2539-2543. doi: 10.2169/internalmedicine.2842-19. Epub 2019 May 22. Intern Med. 2019. PMID: 31118405 Free PMC article.
Of note, the reduction in extracellular edema in the left ventricular wall was clearly visualized by changes in the native T1 values and extracellular volumes on cardiac magnetic resonance imaging....
Of note, the reduction in extracellular edema in the left ventricular wall was clearly visualized by changes in the native T1 values …
Targeting Attenuated Interferon-α to Myeloma Cells with a CD38 Antibody Induces Potent Tumor Regression with Reduced Off-Target Activity.
Pogue SL, Taura T, Bi M, Yun Y, Sho A, Mikesell G, Behrens C, Sokolovsky M, Hallak H, Rosenstock M, Sanchez E, Chen H, Berenson J, Doyle A, Nock S, Wilson DS. Pogue SL, et al. PLoS One. 2016 Sep 9;11(9):e0162472. doi: 10.1371/journal.pone.0162472. eCollection 2016. PLoS One. 2016. PMID: 27611189 Free PMC article.
This anti-CD38-IFNalpha(attenuated) immunocytokine, or CD38-Attenukine, exhibits 10,000-fold increased specificity for CD38 positive cells in vitro compared to native IFNalpha and, significantly, is ~6,000-fold less toxic to normal bone marrow cells in vitro than native …
This anti-CD38-IFNalpha(attenuated) immunocytokine, or CD38-Attenukine, exhibits 10,000-fold increased specificity for CD38 positive cells i …