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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2003 1
2004 1
2005 2
2007 1
2009 5
2010 2
2011 1
2012 1
2013 1
2014 3
2015 3
2016 2
2017 4
2019 2
2020 8
2021 4
2022 1
2023 3
2024 2

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42 results

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Page 1
Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER+ Breast Cancer.
Servetto A, Kollipara R, Formisano L, Lin CC, Lee KM, Sudhan DR, Gonzalez-Ericsson PI, Chatterjee S, Guerrero-Zotano A, Mendiratta S, Akamatsu H, James N, Bianco R, Hanker AB, Kittler R, Arteaga CL. Servetto A, et al. Clin Cancer Res. 2021 Aug 1;27(15):4379-4396. doi: 10.1158/1078-0432.CCR-20-3905. Epub 2021 May 19. Clin Cancer Res. 2021. PMID: 34011560 Free PMC article.
PURPOSE: FGFR1 overexpression has been associated with endocrine resistance in ER(+) breast cancer. We found FGFR1 localized in the nucleus of breast cancer cells in primary tumors resistant to estrogen suppression. ...RESULTS: High nuclear FGFR1 expression in ER(+) primar …
PURPOSE: FGFR1 overexpression has been associated with endocrine resistance in ER(+) breast cancer. We found FGFR1 localized in the nucle …
Effect of Hypoglycemic Drugs on Kisspeptin Expression in the Hypothalamic Arcuate Nucleus of PCOS Rats.
Zheng P, Lu Y, Tang Y, Xu F, Wang L, Qian R, Hui C, Xu Q, He J, Deng D. Zheng P, et al. Diabetes Metab Syndr Obes. 2023 Sep 7;16:2717-2732. doi: 10.2147/DMSO.S421911. eCollection 2023. Diabetes Metab Syndr Obes. 2023. PMID: 37701721 Free PMC article.
BACKGROUND: To investigate the change in hypothalamic kisspeptin-1 (Kiss1) expression during the development of polycystic ovary syndrome (PCOS) and hypoglycemic drug intervention. METHODS: Letrozole lavage was used to construct a polycystic ovary rat model. ...
BACKGROUND: To investigate the change in hypothalamic kisspeptin-1 (Kiss1) expression during the development of polycystic ovary syndrome (P …
Effect of Letrozole on sperm parameters, chromatin status and ROS level in idiopathic Oligo/Astheno/Teratozoospermia.
Kooshesh L, Bahmanpour S, Zeighami S, Nasr-Esfahani MH. Kooshesh L, et al. Reprod Biol Endocrinol. 2020 May 13;18(1):47. doi: 10.1186/s12958-020-00591-2. Reprod Biol Endocrinol. 2020. PMID: 32404173 Free PMC article. Clinical Trial.
Finally, the differences between the parameters evaluated before and after letrozole treatment were analyzed with the t-test and the Wilcoxon signed-rank test. ...The mean of T:E2 ratio improved 1600%. Also, letrozole treatment significantly reduced the percentage o …
Finally, the differences between the parameters evaluated before and after letrozole treatment were analyzed with the t-test and the …
Distribution of estrogen receptors alpha and beta in the brain of male rats with same-sex preference.
Phillips-Farfán BV, Quintanar BG, Reyes R, Fernández-Guasti A. Phillips-Farfán BV, et al. Physiol Behav. 2023 Sep 1;268:114237. doi: 10.1016/j.physbeh.2023.114237. Epub 2023 May 14. Physiol Behav. 2023. PMID: 37192686
ERalpha and ERbeta expression was analyzed by immunohistochemistry in brain areas known to control masculine sexual behavior and partner preference, like the medial preoptic area (MPOA), bed nucleus of the stria terminalis (BNST), medial amygdala (MeA) and ventromedial hyp …
ERalpha and ERbeta expression was analyzed by immunohistochemistry in brain areas known to control masculine sexual behavior and partner pre …
Prenatal administration of letrozole reduces SDN and SCN volume and cell number independent of partner preference in the male rat.
Olvera-Hernández S, Tapia-Rodríguez M, Swaab DF, Fernández-Guasti A. Olvera-Hernández S, et al. Physiol Behav. 2017 Mar 15;171:61-68. doi: 10.1016/j.physbeh.2017.01.001. Epub 2017 Jan 3. Physiol Behav. 2017. PMID: 28057567
The aim of this study was to compare the volume and number of cells of the SDN and SCN (the latter nucleus was immunohistochemically stained for vasopressin) between males treated with letrozole with same-sex preference, males treated with letrozole with fema …
The aim of this study was to compare the volume and number of cells of the SDN and SCN (the latter nucleus was immunohistochemically …
Sex-dimorphic aromatase regulation of ventromedial hypothalamic nucleus glycogen content in euglycemic and insulin-induced hypoglycemic rats.
Ibrahim MMH, Uddin MM, Bheemanapally K, Briski KP. Ibrahim MMH, et al. Neurosci Lett. 2020 Oct 15;737:135284. doi: 10.1016/j.neulet.2020.135284. Epub 2020 Aug 25. Neurosci Lett. 2020. PMID: 32853718 Free PMC article.
Glycogen metabolism impacts metabolic transmitter signaling in the ventromedial hypothalamic nucleus (VMN), a key glucoregulatory structure. Aromatase, the enzyme that converts testosterone to estradiol, is expressed at high levels in the VMN. ...Testes-intact male and est …
Glycogen metabolism impacts metabolic transmitter signaling in the ventromedial hypothalamic nucleus (VMN), a key glucoregulatory str …
Aromatase inhibitor letrozole downregulates steroid receptor coactivator-1 in specific brain regions that primarily related to memory, neuroendocrine and integration.
Bian C, Zhao Y, Guo Q, Xiong Y, Cai W, Zhang J. Bian C, et al. J Steroid Biochem Mol Biol. 2014 May;141:37-43. doi: 10.1016/j.jsbmb.2013.12.020. Epub 2014 Jan 13. J Steroid Biochem Mol Biol. 2014. PMID: 24434281
The results showed that letrozole induced dramatic decrease of SRC-1 in the medial septal, hippocampus, medial habenular nucleus, arcuate hypothalamic nucleus and superior colliculus (p<0.01). Significant decrease was detected in the dorsal lateral septal …
The results showed that letrozole induced dramatic decrease of SRC-1 in the medial septal, hippocampus, medial habenular nucleus …
Hyperactive LH Pulses and Elevated Kisspeptin and NKB Gene Expression in the Arcuate Nucleus of a PCOS Mouse Model.
Esparza LA, Schafer D, Ho BS, Thackray VG, Kauffman AS. Esparza LA, et al. Endocrinology. 2020 Apr 1;161(4):bqaa018. doi: 10.1210/endocr/bqaa018. Endocrinology. 2020. PMID: 32031594 Free PMC article.
We recently reported a novel mouse model of PCOS using chronic letrozole (LET; aromatase inhibitor). Letrozole-treated females demonstrate multiple PCOS-like phenotypes, including polycystic ovaries, anovulation, and elevated circulating testosterone and LH, assayed …
We recently reported a novel mouse model of PCOS using chronic letrozole (LET; aromatase inhibitor). Letrozole-treated females …
Effects of the Fertility Drugs Clomiphene Citrate and Letrozole on Kiss-1 Expression in Hypothalamic Kiss-1-Expressing Cell Models.
Oride A, Kanasaki H, Tumurbaatar T, Zolzaya T, Okada H, Hara T, Kyo S. Oride A, et al. Reprod Sci. 2020 Mar;27(3):806-814. doi: 10.1007/s43032-020-00154-1. Epub 2020 Jan 31. Reprod Sci. 2020. PMID: 32006244
We examined whether these drugs increase Kiss-1 expression in hypothalamic cell models. We utilized two hypothalamic cell models, mHypoA-50 and mHypoA-55, which originated from Kiss-1 neurons in the anteroventral periventricular (AVPV) nucleus and arcuate (AR …
We examined whether these drugs increase Kiss-1 expression in hypothalamic cell models. We utilized two hypothalamic cell mode …
Aromatase, aromatase inhibitors, and breast cancer.
Brueggemeier RW. Brueggemeier RW. Am J Ther. 2001 Sep-Oct;8(5):333-44. doi: 10.1097/00045391-200109000-00007. Am J Ther. 2001. PMID: 11550075 Review.
Steroidal inhibitors that have been developed to date build on the basic androstenedione nucleus and incorporate chemical substituents at varying positions on the steroid. ...The potent and selective third-generation aromatase inhibitors anastrozole, letrozole, and …
Steroidal inhibitors that have been developed to date build on the basic androstenedione nucleus and incorporate chemical substituent …
42 results