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1988 1
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2002 7
2003 7
2004 15
2005 16
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2008 36
2009 30
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942 results

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Page 1
Search in the Periphery for Potential Inflammatory Biomarkers of Dementia with Lewy Bodies and Alzheimer's Disease.
Costantini E, Carrarini C, Calisi D, De Rosa M, Simone M, Di Crosta A, Palumbo R, Cipollone A, Aielli L, De Laurentis M, Colarusso L, Pilotto A, Padovani A, Konstantinidou F, Gatta V, Stuppia L, Cipollone F, Di Nicola M, Reale M, Bonanni L. Costantini E, et al. J Alzheimers Dis. 2024 May 16. doi: 10.3233/JAD-231471. Online ahead of print. J Alzheimers Dis. 2024. PMID: 38759010
BACKGROUND: Neuroinflammation, with altered peripheral proinflammatory cytokine production, plays a major role in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease (AD), while the role of inflammation in dementia with Lewy bodies (DLB) is less kno …
BACKGROUND: Neuroinflammation, with altered peripheral proinflammatory cytokine production, plays a major role in the pathogenesis of neurod …
Phloroglucinol Derivatives Exert Anti-inflammatory Effects and Attenuate Cognitive Impairment in LPS-induced Mouse Model.
Kim J, Choi JW, Kim HJ, Kim B, Kim Y, Lee EH, Kim R, Kim J, Park J, Jeong Y, Park JH, Park KD. Kim J, et al. ChemMedChem. 2024 May 16:e202400056. doi: 10.1002/cmdc.202400056. Online ahead of print. ChemMedChem. 2024. PMID: 38757206
It is one of the primary causes of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Phloroglucinol (PG) is a natural product contained in extracts of plant, algae and microbe and has been reported to have antioxidant and …
It is one of the primary causes of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease …
RND3 modulates microglial polarization and alleviates neuroinflammation in Parkinson's Disease by suppressing NLRP3 inflammasome activation.
Hu W, Wang M, Sun G, Zhang L, Lu H. Hu W, et al. Exp Cell Res. 2024 May 12:114088. doi: 10.1016/j.yexcr.2024.114088. Online ahead of print. Exp Cell Res. 2024. PMID: 38744409
Neuroinflammation mediated by microglia plays an important role in the etiology of Parkinson's disease (PD). Rho family GTPase 3 (RND3) exerts anti-inflammatory effects and may act as a potential new inducer of neuroprotective phenotypes in microglia. ...Take …
Neuroinflammation mediated by microglia plays an important role in the etiology of Parkinson's disease (PD). Rho family …
The landscape of rare genetic variation associated with inflammatory bowel disease and Parkinson's disease comorbidity.
Kars ME, Wu Y, Stenson PD, Cooper DN, Burisch J, Peter I, Itan Y. Kars ME, et al. Genome Med. 2024 May 14;16(1):66. doi: 10.1186/s13073-024-01335-2. Genome Med. 2024. PMID: 38741190 Free PMC article.
BACKGROUND: Inflammatory bowel disease (IBD) and Parkinson's disease (PD) are chronic disorders that have been suggested to share common pathophysiological processes. ...Additionally, we detected significantly enriched pathways unique to the IBD-PD, in …
BACKGROUND: Inflammatory bowel disease (IBD) and Parkinson's disease (PD) are chronic disorders that have been s …
Impact of alogliptin on lipopolysaccharide-induced experimental Parkinson's disease: Unrevealing neurochemical and histopathological alterations in rodents.
Dhureja M, Deshmukh R. Dhureja M, et al. Eur J Pharmacol. 2024 May 10;975:176635. doi: 10.1016/j.ejphar.2024.176635. Online ahead of print. Eur J Pharmacol. 2024. PMID: 38734296
BACKGROUND: Degeneration of the nigrostriatal dopaminergic pathway has been seen as a significant cause of movement disability in Parkinson's disease (PD) patients. However, the exact reason for these degenerative changes has remained obscure. ...Nonetheless, …
BACKGROUND: Degeneration of the nigrostriatal dopaminergic pathway has been seen as a significant cause of movement disability in Parkins …
Positron Emission Tomography with [18F]ROStrace Reveals Progressive Elevations in Oxidative Stress in a Mouse Model of Alpha-Synucleinopathy.
Gallagher E, Hou C, Zhu Y, Hsieh CJ, Lee H, Li S, Xu K, Henderson P, Chroneos R, Sheldon M, Riley S, Luk KC, Mach RH, McManus MJ. Gallagher E, et al. Int J Mol Sci. 2024 May 1;25(9):4943. doi: 10.3390/ijms25094943. Int J Mol Sci. 2024. PMID: 38732162 Free PMC article.
A53T-specific elevations in [(18)F]ROStrace signal emerged at a relatively early age (6-8 months) and became more widespread within the brain over time, a pattern which paralleled the progressive development of aSyn pathology and oxidative damage in A53T brain tissue. Systemic ad …
A53T-specific elevations in [(18)F]ROStrace signal emerged at a relatively early age (6-8 months) and became more widespread within the brai …
Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation.
Yang R, Li DD, Li XX, Yang XX, Gao HM, Zhang F. Yang R, et al. Int J Biol Macromol. 2024 May 7;269(Pt 2):132179. doi: 10.1016/j.ijbiomac.2024.132179. Online ahead of print. Int J Biol Macromol. 2024. PMID: 38723817
BACKGROUND: Parkinson's disease (PD) is a prevalent neurodegenerative disorder, marked by the degeneration of dopamine (DA) neurons in the substantia nigra (SN). ...RESULTS: The main findings demonstrated that DHQ effectively protected DA neurons against neur …
BACKGROUND: Parkinson's disease (PD) is a prevalent neurodegenerative disorder, marked by the degeneration of dopamine …
Botulinum toxin A attenuates osteoarthritis development via inhibiting chondrocyte ferroptosis through SLC7Al1/GPX4 axis.
Zeng L, Liu Y, Wang Q, Wan H, Meng X, Tu P, Chen H, Luo A, Hu P, Ding X. Zeng L, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Jun;1870(5):167215. doi: 10.1016/j.bbadis.2024.167215. Epub 2024 May 6. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38714267
Osteoarthritis (OA) is a prevalent joint degenerative disease, resulting in a significant societal burden. However, there is currently a lack of effective treatment option available. ...It also enhanced the degeneration of extracellular matrix (ECM) and altered the ferropt …
Osteoarthritis (OA) is a prevalent joint degenerative disease, resulting in a significant societal burden. However, there is currentl …
Microglial SIX2 suppresses lipopolysaccharide (LPS)-induced neuroinflammation by up-regulating FXYD2 expression.
Cao XY, Liu Y, Kan JS, Huang XX, Kambey PA, Zhang CT, Gao J. Cao XY, et al. Brain Res Bull. 2024 Apr 28;212:110970. doi: 10.1016/j.brainresbull.2024.110970. Online ahead of print. Brain Res Bull. 2024. PMID: 38688414 Free article.
Parkinson's disease (PD) is a severe neurodegenerative disease associated with the loss of dopaminergic (DA) neurons in the substantia nigra (SN). ...The SIX2 protein, which is silenced during development, was reactivated in lipopolysaccharide (LPS …
Parkinson's disease (PD) is a severe neurodegenerative disease associated with the loss of dopaminergic (DA) neu …
Ser9p-GSK3β Modulation Contributes to the Protective Effects of Vitamin C in Neuroinflammation.
Ruggiero M, Cianciulli A, Calvello R, Porro C, De Nuccio F, Kashyrina M, Miraglia A, Lofrumento DD, Panaro MA. Ruggiero M, et al. Nutrients. 2024 Apr 10;16(8):1121. doi: 10.3390/nu16081121. Nutrients. 2024. PMID: 38674812 Free PMC article.
BACKGROUND: The prolonged activation of microglia and excessive production of pro-inflammatory cytokines can lead to chronic neuroinflammation, which is an important pathological feature of Parkinson's disease (PD). We have previously reported the protective …
BACKGROUND: The prolonged activation of microglia and excessive production of pro-inflammatory cytokines can lead to chronic neuroinflammati …
942 results