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Role of lysophosphatidic acid and its receptors in the kidney.
Park F, Miller DD. Park F, et al. Physiol Genomics. 2017 Nov 1;49(11):659-666. doi: 10.1152/physiolgenomics.00070.2017. Epub 2017 Sep 22. Physiol Genomics. 2017. PMID: 28939644 Review.
Lysophosphatidic acid (LPA) is a bioactive phospholipid that can exert diverse biological effects in various diseased states of the kidney by activating at least six cognate G protein-coupled receptors and its complex network of heterotrimeric G proteins. ... …
Lysophosphatidic acid (LPA) is a bioactive phospholipid that can exert diverse biological effects in various diseased states o …
Lysophosphatidic acid and its receptors: pharmacology and therapeutic potential in atherosclerosis and vascular disease.
Zhou Y, Little PJ, Ta HT, Xu S, Kamato D. Zhou Y, et al. Pharmacol Ther. 2019 Dec;204:107404. doi: 10.1016/j.pharmthera.2019.107404. Epub 2019 Aug 28. Pharmacol Ther. 2019. PMID: 31472182 Review.
Lysophosphatidic acid (LPA) is a collective name for a set of bioactive lipid species. Via six widely distributed G protein-coupled receptors (GPCRs), LPA elicits a plethora of biological responses, contributing to inflammation, thrombosis and atherosclerosis …
Lysophosphatidic acid (LPA) is a collective name for a set of bioactive lipid species. Via six widely distributed G protein-co …
Lysophosphatidic acid receptors (LPARs): Potential targets for the treatment of neuropathic pain.
Velasco M, O'Sullivan C, Sheridan GK. Velasco M, et al. Neuropharmacology. 2017 Feb;113(Pt B):608-617. doi: 10.1016/j.neuropharm.2016.04.002. Epub 2016 Apr 5. Neuropharmacology. 2017. PMID: 27059127 Review.
Clinically, neuropathic pain can manifest in many chronic disease states such as cancer, diabetes or multiple sclerosis (MS). The bioactive lipid, lysophosphatidic acid (LPA), via activation of its receptors (LPARs), is thought to play a central role in both …
Clinically, neuropathic pain can manifest in many chronic disease states such as cancer, diabetes or multiple sclerosis (MS). The bioactive …
Lysophosphatidic acid receptors in cancer pathobiology.
Tsujiuchi T, Araki M, Hirane M, Dong Y, Fukushima N. Tsujiuchi T, et al. Histol Histopathol. 2014 Mar;29(3):313-21. doi: 10.14670/HH-29.313. Epub 2013 Nov 6. Histol Histopathol. 2014. PMID: 24194373 Review.
Lysophosphatidic acid (LPA) receptors (LPA1 to LPA6) are G protein-coupled transmembrane and mediate a variety of biological responses through the binding of LPA, such as cell proliferation, migration, morphogenesis and differentiation. ...Here, we review the …
Lysophosphatidic acid (LPA) receptors (LPA1 to LPA6) are G protein-coupled transmembrane and mediate a variety of biolo …
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies.
Geraldo LHM, Spohr TCLS, Amaral RFD, Fonseca ACCD, Garcia C, Mendes FA, Freitas C, dosSantos MF, Lima FRS. Geraldo LHM, et al. Signal Transduct Target Ther. 2021 Feb 1;6(1):45. doi: 10.1038/s41392-020-00367-5. Signal Transduct Target Ther. 2021. PMID: 33526777 Free PMC article. Review.
Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions both in development and in pathological conditions. ...Ultimately, we review the preclinical and clinical uses of Autotaxin, LPA, and its receptors as therapeutic targe …
Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions both in development and in patholog …
G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling.
Riaz A, Huang Y, Johansson S. Riaz A, et al. Int J Mol Sci. 2016 Feb 5;17(2):215. doi: 10.3390/ijms17020215. Int J Mol Sci. 2016. PMID: 26861299 Free PMC article. Review.
A hallmark of G-protein-coupled receptors (GPCRs) is their ability to recognize and respond to chemically diverse ligands. Lysophospholipids constitute a relatively recent addition to these ligands and carry out their biological functions by activating G-proteins coupled t …
A hallmark of G-protein-coupled receptors (GPCRs) is their ability to recognize and respond to chemically diverse ligands. Lysophosph …
The development of modulators for lysophosphatidic acid receptors: A comprehensive review.
Liu W, Hopkins AM, Hou J. Liu W, et al. Bioorg Chem. 2021 Dec;117:105386. doi: 10.1016/j.bioorg.2021.105386. Epub 2021 Oct 4. Bioorg Chem. 2021. PMID: 34695732 Review.
Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities that regulate a diverse array of biological functions. They recognize two types of G protein-coupled receptors (LPARs): LPA(1-3) receptors and LPA(4-6) …
Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities that regulate a diverse a …
Lysophosphatidic acid (LPA) and its receptors: role in airway inflammation and remodeling.
Zhao Y, Natarajan V. Zhao Y, et al. Biochim Biophys Acta. 2013 Jan;1831(1):86-92. doi: 10.1016/j.bbalip.2012.06.014. Epub 2012 Jul 15. Biochim Biophys Acta. 2013. PMID: 22809994 Free PMC article. Review.
Lysophosphatidic acid (LPA), a simple bioactive phospholipid, is present in biological fluids such as plasma and bronchoalveolar lavage (BAL). ...The biological effects of LPA are mediated through its cell surface G-protein coupled LPA(1-7) receptors. The rol …
Lysophosphatidic acid (LPA), a simple bioactive phospholipid, is present in biological fluids such as plasma and bronchoalveol …
Phase 2 trial design of BMS-986278, a lysophosphatidic acid receptor 1 (LPA(1)) antagonist, in patients with idiopathic pulmonary fibrosis (IPF) or progressive fibrotic interstitial lung disease (PF-ILD).
Corte TJ, Lancaster L, Swigris JJ, Maher TM, Goldin JG, Palmer SM, Suda T, Ogura T, Minnich A, Zhan X, Tirucherai GS, Elpers B, Xiao H, Watanabe H, Smith RA, Charles ED, Fischer A. Corte TJ, et al. BMJ Open Respir Res. 2021 Dec;8(1):e001026. doi: 10.1136/bmjresp-2021-001026. BMJ Open Respir Res. 2021. PMID: 34969771 Free PMC article. Clinical Trial.
Treatment with antifibrotic agents can slow, but not halt, disease progression, and treatment discontinuation because of adverse events is common. Fibrotic diseases such as these can be mediated by lysophosphatidic acid (LPA), which signals via six LPA receptors …
Treatment with antifibrotic agents can slow, but not halt, disease progression, and treatment discontinuation because of adverse events is c …
Non-Edg family lysophosphatidic acid (LPA) receptors.
Ishii S, Noguchi K, Yanagida K. Ishii S, et al. Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):57-65. doi: 10.1016/j.prostaglandins.2009.06.001. Epub 2009 Jun 12. Prostaglandins Other Lipid Mediat. 2009. PMID: 19524700 Review.
Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycero-3-phosphate) is a bioactive phospholipid with mitogenic and/or morphological effects on many cell types. ...It was originally thought that the cellular effects of LPA are mediated by three subtypes of G-protein-cou …
Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycero-3-phosphate) is a bioactive phospholipid with mitogenic and/or morphologic …
2,572 results