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1975 1
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3,259 results

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Page 1
Therapeutic Strategy of Mesenchymal-Stem-Cell-Derived Extracellular Vesicles as Regenerative Medicine.
Matsuzaka Y, Yashiro R. Matsuzaka Y, et al. Int J Mol Sci. 2022 Jun 9;23(12):6480. doi: 10.3390/ijms23126480. Int J Mol Sci. 2022. PMID: 35742923 Free PMC article. Review.
Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal ability derived from bone marrow, fat, umbilical cord, menstruation blood, pulp, etc., which they use to induce tissue regeneration by their direct recruitment into injured tissues, including …
Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal ability derived from bone marrow, fat, umbilical cord, …
Recent developments in bio-scaffold materials as delivery strategies for therapeutics for endometrium regeneration.
Li X, Lv HF, Zhao R, Ying MF, Samuriwo AT, Zhao YZ. Li X, et al. Mater Today Bio. 2021 Feb 25;11:100101. doi: 10.1016/j.mtbio.2021.100101. eCollection 2021 Jun. Mater Today Bio. 2021. PMID: 34036261 Free PMC article. Review.
Intrauterine adhesions (IUAs) refer to the repair disorder after endometrial injury and may lead to uterine infertility, recurrent miscarriage, abnormal menstrual bleeding, and other obstetric complications. It is a pressing public health issue among women of childbearing …
Intrauterine adhesions (IUAs) refer to the repair disorder after endometrial injury and may lead to uterine infertility, recurrent miscarria …
Current regenerative medicine-based approaches for skin regeneration: A review of literature and a report on clinical applications in Japan.
Shimizu Y, Ntege EH, Sunami H. Shimizu Y, et al. Regen Ther. 2022 Jun 15;21:73-80. doi: 10.1016/j.reth.2022.05.008. eCollection 2022 Dec. Regen Ther. 2022. PMID: 35785041 Free PMC article. Review.
Cell-based therapies include mesenchymal stem cells (MSCs), tissue induced pluripotent stem cells (iPSCs), fibroblast-based products, and blood-derived therapies, such as those employing platelet-rich plasma (PRP) products. Cell-free therapies primarily involve the use of MSC …
Cell-based therapies include mesenchymal stem cells (MSCs), tissue induced pluripotent stem cells (iPSCs), fibroblast-based products, and bl …
Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cell Therapy for Rheumatoid Arthritis Patients: A Prospective Phase I/II Study.
Wang L, Huang S, Li S, Li M, Shi J, Bai W, Wang Q, Zheng L, Liu Y. Wang L, et al. Drug Des Devel Ther. 2019 Dec 19;13:4331-4340. doi: 10.2147/DDDT.S225613. eCollection 2019. Drug Des Devel Ther. 2019. PMID: 31908418 Free PMC article. Clinical Trial.
BACKGROUND: The traditional anti-inflammation disease-modifying anti-rheumatic drugs (DMARDs) have limited therapeutic effects in rheumatoid arthritis (RA) patients. We previously reported the safety and efficacy of umbilical cord mesenchymal stem cell (UC-MSC) trea …
BACKGROUND: The traditional anti-inflammation disease-modifying anti-rheumatic drugs (DMARDs) have limited therapeutic effects in rheumatoid …
Comprehensive proteomic analysis of exosomes derived from human bone marrow, adipose tissue, and umbilical cord mesenchymal stem cells.
Wang ZG, He ZY, Liang S, Yang Q, Cheng P, Chen AM. Wang ZG, et al. Stem Cell Res Ther. 2020 Nov 27;11(1):511. doi: 10.1186/s13287-020-02032-8. Stem Cell Res Ther. 2020. PMID: 33246507 Free PMC article.
BACKGROUND: Mesenchymal stem cell (MSC)-derived exosomes have shown comprehensive application prospects over the years. ...RESULTS: Bioinformatics analysis revealed their shared function in the extracellular matrix receptor. Bone marrow MSC-derived exosomes showed s …
BACKGROUND: Mesenchymal stem cell (MSC)-derived exosomes have shown comprehensive application prospects over the years. ...RESULTS: B …
Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF-beta upregulation, microvascular stabilization and functional recovery in a rodent model of severe spinal cord injury.
Nakazaki M, Morita T, Lankford KL, Askenase PW, Kocsis JD. Nakazaki M, et al. J Extracell Vesicles. 2021 Sep;10(11):e12137. doi: 10.1002/jev2.12137. J Extracell Vesicles. 2021. PMID: 34478241 Free PMC article.
Intravenous (IV) infusion of bone marrow-derived mesenchymal stem/stromal cells (MSCs) stabilizes the blood-spinal cord barrier (BSCB) and improves functional recovery in experimental models of spinal cord injury (SCI). ...We found that sEVs were released by MSCs in …
Intravenous (IV) infusion of bone marrow-derived mesenchymal stem/stromal cells (MSCs) stabilizes the blood-spinal cord barrier (BSCB …
Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization.
Dong B, Wang C, Zhang J, Zhang J, Gu Y, Guo X, Zuo X, Pan H, Hsu AC, Wang G, Wang F. Dong B, et al. Stem Cell Res Ther. 2021 Mar 24;12(1):204. doi: 10.1186/s13287-021-02244-6. Stem Cell Res Ther. 2021. PMID: 33761997 Free PMC article.
In this study, we explored the therapeutic effects of MSC-Exo in SSRA and identified the therapeutic mechanism of MSC-Exo. ...Systematic depletion of macrophages weakened the therapeutic effect of MSC-Exo. We found that MSC-Exo treatment inhibited M1 p …
In this study, we explored the therapeutic effects of MSC-Exo in SSRA and identified the therapeutic mechanism of MSC-Exo. ... …
hUC-MSC-mediated recovery of subacute spinal cord injury through enhancing the pivotal subunits beta3 and gamma2 of the GABA(A) receptor.
Cao T, Chen H, Huang W, Xu S, Liu P, Zou W, Pang M, Xu Y, Bai X, Liu B, Rong L, Cui ZK, Li M. Cao T, et al. Theranostics. 2022 Mar 28;12(7):3057-3078. doi: 10.7150/thno.72015. eCollection 2022. Theranostics. 2022. PMID: 35547766 Free PMC article.
We carried out extensive transcriptome comparative analyses of spinal cord tissues at the lesion site from the subacute phase of SCI (sub-SCI) either treated without (+PBS) or with hUC-MSCs (+MSC) at 0 (sub-SCI), 1, 2, and 4 weeks post-transplantation (wpt), as well …
We carried out extensive transcriptome comparative analyses of spinal cord tissues at the lesion site from the subacute phase of SCI …
Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury.
Guo S, Perets N, Betzer O, Ben-Shaul S, Sheinin A, Michaelevski I, Popovtzer R, Offen D, Levenberg S. Guo S, et al. ACS Nano. 2019 Sep 24;13(9):10015-10028. doi: 10.1021/acsnano.9b01892. Epub 2019 Aug 29. ACS Nano. 2019. PMID: 31454225
Here, we demonstrate that when given intranasally, exosomes derived from mesenchymal stem cells (MSC-Exo) could pass the blood brain barrier and migrate to the injured spinal cord area. Furthermore, MSC-Exo loaded with phosphatase and tensin homolog small int …
Here, we demonstrate that when given intranasally, exosomes derived from mesenchymal stem cells (MSC-Exo) could pass the blood brain …
Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate liver steatosis by promoting fatty acid oxidation and reducing fatty acid synthesis.
Yang F, Wu Y, Chen Y, Xi J, Chu Y, Jin J, Yan Y. Yang F, et al. JHEP Rep. 2023 Mar 28;5(7):100746. doi: 10.1016/j.jhepr.2023.100746. eCollection 2023 Jul. JHEP Rep. 2023. PMID: 37274776 Free PMC article.
Liver steatosis is a primary characteristic of NAFLD. Recent studies suggest that human umbilical cord mesenchymal stem cell-derived exosomes (MSC-ex) may provide a promising strategy for treating liver injury; however, the role and underlying mechanisms of MSC …
Liver steatosis is a primary characteristic of NAFLD. Recent studies suggest that human umbilical cord mesenchymal stem cell-derived …
3,259 results