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Did you mean metformin (31,589 results)?
Human trials exploring anti-aging medicines.
Guarente L, Sinclair DA, Kroemer G. Guarente L, et al. Cell Metab. 2024 Feb 6;36(2):354-376. doi: 10.1016/j.cmet.2023.12.007. Epub 2024 Jan 4. Cell Metab. 2024. PMID: 38181790 Review.
Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin, NAD(+) precursors, glucagon-like peptide-1 receptor agonists, TORC1 inhibitors, spermidine, senolytics, probiotics, and anti-inflammatori …
Here, we summarize the current knowledge on eight promising drugs and natural compounds that have been tested in the clinic: metformin …
Metformin in 2019.
Flory J, Lipska K. Flory J, et al. JAMA. 2019 May 21;321(19):1926-1927. doi: 10.1001/jama.2019.3805. JAMA. 2019. PMID: 31009043 Free PMC article. Review.
Metformin was also taken off the US market due to concerns over lactic acidosis, but it subsequently has been proven safe and effective in lowering glucose levels and was reintroduced in 1995. Optimal metformin use requires clear understanding of its effects, dosing …
Metformin was also taken off the US market due to concerns over lactic acidosis, but it subsequently has been proven safe and effecti …
Metformin: update on mechanisms of action and repurposing potential.
Foretz M, Guigas B, Viollet B. Foretz M, et al. Nat Rev Endocrinol. 2023 Aug;19(8):460-476. doi: 10.1038/s41574-023-00833-4. Epub 2023 May 2. Nat Rev Endocrinol. 2023. PMID: 37130947 Free PMC article. Review.
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in most guidelines and is used daily by >200 million patients. ...At the molecular level, it seems that the mechanisms of action vary depending on the dose of metformin use …
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in most guidelines and is used daily by &g …
A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan.
Mohammed I, Hollenberg MD, Ding H, Triggle CR. Mohammed I, et al. Front Endocrinol (Lausanne). 2021 Aug 5;12:718942. doi: 10.3389/fendo.2021.718942. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34421827 Free PMC article. Review.
Indeed, clinical trials, including the MILES (Metformin In Longevity Study) and TAME (Targeting Aging with Metformin), have been designed to assess the potential benefits of metformin as an anti-aging drug. Preliminary analysis of results from MILES indicate …
Indeed, clinical trials, including the MILES (Metformin In Longevity Study) and TAME (Targeting Aging with Metformin), have be …
Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms.
Chen S, Gan D, Lin S, Zhong Y, Chen M, Zou X, Shao Z, Xiao G. Chen S, et al. Theranostics. 2022 Mar 6;12(6):2722-2740. doi: 10.7150/thno.71360. eCollection 2022. Theranostics. 2022. PMID: 35401820 Free PMC article. Review.
In this review, we provide updated information and knowledge on applications of metformin in prevention and treatment of aging and aging-related diseases. We focus our discussions on the roles and underlying mechanisms of metformin in modulating aging and treating a …
In this review, we provide updated information and knowledge on applications of metformin in prevention and treatment of aging and ag …
The effects of metformin on autophagy.
Lu G, Wu Z, Shang J, Xie Z, Chen C, Zhang C. Lu G, et al. Biomed Pharmacother. 2021 May;137:111286. doi: 10.1016/j.biopha.2021.111286. Epub 2021 Jan 30. Biomed Pharmacother. 2021. PMID: 33524789 Free article. Review.
However, the mechanisms of metformin actions were not fully illuminated. Recently, increasing researches showed that autophagy is a vital medium of metformin playing pharmacological actions. ...The pharmacological effects of metformin combining its actions on …
However, the mechanisms of metformin actions were not fully illuminated. Recently, increasing researches showed that autophagy is a v …
Mechanisms of ageing: growth hormone, dietary restriction, and metformin.
Khan J, Pernicova I, Nisar K, Korbonits M. Khan J, et al. Lancet Diabetes Endocrinol. 2023 Apr;11(4):261-281. doi: 10.1016/S2213-8587(23)00001-3. Epub 2023 Feb 24. Lancet Diabetes Endocrinol. 2023. PMID: 36848915 Review.
Life extension has been achieved in animal models by suppressing the growth hormone-insulin-like growth factor 1 (IGF-1) axis and also via dietary restriction. Metformin has become the focus of increased interest as a possible anti-ageing drug. ...In this Review, we draw o …
Life extension has been achieved in animal models by suppressing the growth hormone-insulin-like growth factor 1 (IGF-1) axis and also via d …
Therapeutic Use of Metformin in Prediabetes and Diabetes Prevention.
Hostalek U, Gwilt M, Hildemann S. Hostalek U, et al. Drugs. 2015 Jul;75(10):1071-94. doi: 10.1007/s40265-015-0416-8. Drugs. 2015. PMID: 26059289 Free PMC article. Review.
Lifestyle interventions aimed at inducing weight loss, pharmacologic treatments (metformin, thiazolidinediones, acarbose, basal insulin and drugs for weight loss) and bariatric surgery have all been shown to reduce the risk of progression to type 2 diabetes in prediabetic …
Lifestyle interventions aimed at inducing weight loss, pharmacologic treatments (metformin, thiazolidinediones, acarbose, basal insul …
Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis.
Coyle C, Cafferty FH, Vale C, Langley RE. Coyle C, et al. Ann Oncol. 2016 Dec;27(12):2184-2195. doi: 10.1093/annonc/mdw410. Epub 2016 Sep 28. Ann Oncol. 2016. PMID: 27681864 Free PMC article. Review.
BACKGROUND: Metformin use has been associated with a reduced risk of developing cancer and an improvement in overall cancer survival rates in meta-analyses, but, to date, evidence to support the use of metformin as an adjuvant therapy in individual cancer types has …
BACKGROUND: Metformin use has been associated with a reduced risk of developing cancer and an improvement in overall cancer survival …
[The role of metformin in the treatment of dermatological diseases: A narrative review].
Monte-Serrano J, Villagrasa-Boli P, Cruañes-Monferrer J, Arbués-Espinosa P, Martínez-Cisneros S, García-Gil MF. Monte-Serrano J, et al. Aten Primaria. 2022 Jun;54(6):102354. doi: 10.1016/j.aprim.2022.102354. Epub 2022 May 12. Aten Primaria. 2022. PMID: 35569426 Free PMC article. Review. Spanish.
OBJETIVE: To review and discuss the current evidence of the use of metformin as a therapeutic tool in frequent skin diseases. DESIGN: Original article. ...In patients with endocrinology-related dermatosis such as hirsutism, acanthosis nigricans and eruptive xanthomas, trea …
OBJETIVE: To review and discuss the current evidence of the use of metformin as a therapeutic tool in frequent skin diseases. DESIGN: …
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