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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 1
1952 1
1957 1
1960 1
1961 1
1962 1
1963 1
1964 4
1965 6
1966 13
1967 10
1968 10
1969 13
1970 21
1971 30
1972 20
1973 19
1974 19
1975 56
1976 66
1977 76
1978 69
1979 82
1980 105
1981 98
1982 121
1983 140
1984 161
1985 150
1986 173
1987 190
1988 159
1989 197
1990 207
1991 224
1992 206
1993 210
1994 191
1995 219
1996 240
1997 221
1998 207
1999 173
2000 194
2001 187
2002 201
2003 190
2004 192
2005 207
2006 214
2007 200
2008 218
2009 221
2010 214
2011 231
2012 233
2013 254
2014 286
2015 282
2016 274
2017 274
2018 278
2019 308
2020 320
2021 331
2022 303
2023 285
2024 126

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9,413 results

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Page 1
Preventing and Managing Toxicities of High-Dose Methotrexate.
Howard SC, McCormick J, Pui CH, Buddington RK, Harvey RD. Howard SC, et al. Oncologist. 2016 Dec;21(12):1471-1482. doi: 10.1634/theoncologist.2015-0164. Epub 2016 Aug 5. Oncologist. 2016. PMID: 27496039 Free PMC article. Review.
Nephrotoxicity results from crystallization of methotrexate in the renal tubular lumen, leading to tubular toxicity. ...Renal toxicity leads to impaired methotrexate clearance and prolonged exposure to toxic concentrations, which further worsen …
Nephrotoxicity results from crystallization of methotrexate in the renal tubular lumen, leading to tubular toxicity. ...Renal …
Methotrexate overdose in clinical practice.
Pannu AK. Pannu AK. Curr Drug Metab. 2019;20(9):714-719. doi: 10.2174/1389200220666190806140844. Curr Drug Metab. 2019. PMID: 31385765 Review.
BACKGROUND: A folic-acid antagonist, methotrexate, is one of the most commonly prescribed drugs with its expanding use in clinical practice. ...METHODS: This review is an update for the clinicians to understand the pharmacology, clinical features, laboratory evaluation, an …
BACKGROUND: A folic-acid antagonist, methotrexate, is one of the most commonly prescribed drugs with its expanding use in clinical pr …
Methotrexate-induced toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses.
Campbell JM, Bateman E, Stephenson MD, Bowen JM, Keefe DM, Peters MD. Campbell JM, et al. Cancer Chemother Pharmacol. 2016 Jul;78(1):27-39. doi: 10.1007/s00280-016-3043-5. Epub 2016 May 3. Cancer Chemother Pharmacol. 2016. PMID: 27142726 Review.
PURPOSE: Methotrexate chemotherapy is associated with various toxicities which can result in the interruption or discontinuation of treatment and a subsequently raised risk of relapse. ...Toxicity outcomes included different forms of hematologic, ectodermal a …
PURPOSE: Methotrexate chemotherapy is associated with various toxicities which can result in the interruption or discontinuati …
Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review.
Wang W, Zhou H, Liu L. Wang W, et al. Eur J Med Chem. 2018 Oct 5;158:502-516. doi: 10.1016/j.ejmech.2018.09.027. Epub 2018 Sep 13. Eur J Med Chem. 2018. PMID: 30243154 Review.
Methotrexate (MTX) is used as an anchor disease-modifying anti-rheumatic drugs (DMARDs) in treating rheumatoid arthritis (RA) because of its potent efficacy and tolerability. ...In this report, we reviewed the possible side effects that MTX might cause from the most common …
Methotrexate (MTX) is used as an anchor disease-modifying anti-rheumatic drugs (DMARDs) in treating rheumatoid arthritis (RA) because …
Methotrexate: Implications of pharmacogenetics in the treatment of patients with Rheumatoid Arthritis.
Torres RP, Santos FP, Branco JC. Torres RP, et al. ARP Rheumatol. 2022 Oct 1;1(3):225-229. ARP Rheumatol. 2022. PMID: 35724450 Free article. Review. English.
BACKGROUND: Methotrexate (MTX) is an anti-folate drug with anti-proliferative and anti-inflammatory effects. ...This review aims to describe the main genetic variants identified concerning proteins that play a role in methotrexate's kinetics and efficiency pr …
BACKGROUND: Methotrexate (MTX) is an anti-folate drug with anti-proliferative and anti-inflammatory effects. ...This review aims to d …
Toxicity associated with high-dose intravenous methotrexate for hematological malignancies.
Wight J, Ku M, Garwood M, Carradice D, Lasica M, Keamy L, Hawkes EA, Grigg A. Wight J, et al. Leuk Lymphoma. 2022 Oct;63(10):2375-2382. doi: 10.1080/10428194.2022.2074987. Epub 2022 May 16. Leuk Lymphoma. 2022. PMID: 35575146
Intravenous high-dose methotrexate (HD-MTX) is a critical chemotherapeutic agent in hematological malignancies, however, data are lacking on how to predict and prevent toxicities such as kidney injury. We retrospectively analyzed 539 episodes of HD-MTX (1 g/m(2)) de …
Intravenous high-dose methotrexate (HD-MTX) is a critical chemotherapeutic agent in hematological malignancies, however, data are lac …
Methotrexate toxicity in growing long bones of young rats: a model for studying cancer chemotherapy-induced bone growth defects in children.
Fan C, Georgiou KR, King TJ, Xian CJ. Fan C, et al. J Biomed Biotechnol. 2011;2011:903097. doi: 10.1155/2011/903097. Epub 2011 Mar 17. J Biomed Biotechnol. 2011. PMID: 21541196 Free PMC article. Review.
However, the underlying mechanisms for chemotherapy-induced skeletal defects remain largely unclear. Methotrexate (MTX), the most commonly used antimetabolite in paediatric cancer treatment, is known to cause bone growth defects in children undergoing chemotherapy. ...Whil …
However, the underlying mechanisms for chemotherapy-induced skeletal defects remain largely unclear. Methotrexate (MTX), the most com …
Methotrexate-induced Leukoencephalopathy: A Rare but Life-threatening Toxicity.
Hussain F, Rehman J, Chaudhry QU, Mahmood SK, Ghafoor T. Hussain F, et al. J Coll Physicians Surg Pak. 2022 Apr;32(4):S44-S46. doi: 10.29271/jcpsp.2022.Supp1.S44. J Coll Physicians Surg Pak. 2022. PMID: 35633009
It is the major drug used in central nervous system (CNS) prophylaxis. Besides, its common hepatic, pulmonary, and hematologic toxicities, it has been implicated in the development of toxic leukoencephalopathy. ...However, cases of irreversible neurologic damage and …
It is the major drug used in central nervous system (CNS) prophylaxis. Besides, its common hepatic, pulmonary, and hematologic toxicities …
Advances in individual prediction of methotrexate toxicity: a review.
Schmiegelow K. Schmiegelow K. Br J Haematol. 2009 Sep;146(5):489-503. doi: 10.1111/j.1365-2141.2009.07765.x. Epub 2009 Jun 15. Br J Haematol. 2009. PMID: 19538530 Free article. Review.
Even when given identical methotrexate doses, patients vary significantly in their response and pattern of toxicities. ...Thus, although high-throughput techniques will allow mapping of tens of thousands of genetic polymorphisms in one run, it will be a major challe …
Even when given identical methotrexate doses, patients vary significantly in their response and pattern of toxicities. ...Thus …
Methotrexate: mechanism of action, pharmacokinetics, clinical indications, and toxicity.
Grosflam J, Weinblatt ME. Grosflam J, et al. Curr Opin Rheumatol. 1991 Jun;3(3):363-8. Curr Opin Rheumatol. 1991. PMID: 1883690 Review.
Methotrexate has become a standard therapy for the treatment of rheumatoid arthritis. ...The effects of methotrexate on liver histology are also summarized....
Methotrexate has become a standard therapy for the treatment of rheumatoid arthritis. ...The effects of methotrexate on liver …
9,413 results

Searches related to "methotrexate toxicity"