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Metreleptin treatment of non-HIV lipodystrophy syndromes.
Chevalier B, Lemaitre M, Leguier L, Mapihan KL, Douillard C, Jannin A, Espiard S, Vantyghem MC. Chevalier B, et al. Presse Med. 2021 Nov;50(3):104070. doi: 10.1016/j.lpm.2021.104070. Epub 2021 Sep 24. Presse Med. 2021. PMID: 34571177 Review.
Because of a common pathophysiology involving decreased concentration of the adipokine leptin, efforts have been made to develop therapeutic strategies with leptin replacement therapy. Metreleptin, a recombinant human leptin analogue, has been proposed in hypoleptinemic pa …
Because of a common pathophysiology involving decreased concentration of the adipokine leptin, efforts have been made to develop therapeutic …
Metreleptin and generalized lipodystrophy and evolving therapeutic perspectives.
Tchang BG, Shukla AP, Aronne LJ. Tchang BG, et al. Expert Opin Biol Ther. 2015 Jul;15(7):1061-75. doi: 10.1517/14712598.2015.1052789. Expert Opin Biol Ther. 2015. PMID: 26063386 Review.
AREAS COVERED: This review covers the physiology of leptin, the pharmacologic properties of recombinant methionyl human leptin (R-metHu-Leptin, metreleptin), evidence for metreleptin's efficacy in the treatment of generalized lipodystrophy from both completed and on …
AREAS COVERED: This review covers the physiology of leptin, the pharmacologic properties of recombinant methionyl human leptin (R-metHu-Lept …
Metreleptin: first global approval.
Chou K, Perry CM. Chou K, et al. Drugs. 2013 Jun;73(9):989-97. doi: 10.1007/s40265-013-0074-7. Drugs. 2013. PMID: 23740412 Review.
Metreleptin is an analogue of the human hormone leptin being developed by Amylin Pharmaceuticals (a subsidiary of Bristol-Myers Squibb) for the subcutaneous treatment of metabolic disorders including lipodystrophy. ...This article summarizes the milestones in the developme …
Metreleptin is an analogue of the human hormone leptin being developed by Amylin Pharmaceuticals (a subsidiary of Bristol-Myers Squib …
Metreleptin Treatment in Patients with Non-HIV Associated Lipodystrophy.
Akinci G, Akinci B. Akinci G, et al. Recent Pat Endocr Metab Immune Drug Discov. 2015;9(2):74-8. doi: 10.2174/1574892811666151111142554. Recent Pat Endocr Metab Immune Drug Discov. 2015. PMID: 26556498 Review.
Limited data has also suggested that metreleptin treatment might be beneficial on metabolic abnormalities in patients with partial lipodystrophy. This review focuses on potential benefits of metreleptin in various forms of non-HIV associated lipodystrophy. Safety is …
Limited data has also suggested that metreleptin treatment might be beneficial on metabolic abnormalities in patients with partial li …
The Metreleptin Effectiveness and Safety Registry (MEASuRE): concept, design and challenges.
Haymond MW, Araújo-Vilar D, Balser J, Lewis JH, Louzado R, Musso C, von Schnurbein J, Wabitsch M; MEASuRE group. Haymond MW, et al. Orphanet J Rare Dis. 2023 May 26;18(1):127. doi: 10.1186/s13023-023-02714-5. Orphanet J Rare Dis. 2023. PMID: 37237416 Free PMC article.
MEASuRE (Metreleptin Effectiveness And Safety Registry) is a post-authorization, voluntary registry that gathers long-term safety and effectiveness data on metreleptin. ...METHODS: MEASuRE was established to collect data from patients receiving commercially supplied …
MEASuRE (Metreleptin Effectiveness And Safety Registry) is a post-authorization, voluntary registry that gathers long-term safety and …
Pharmacotherapy of obesity: an update on the available medications and drugs under investigation.
Chakhtoura M, Haber R, Ghezzawi M, Rhayem C, Tcheroyan R, Mantzoros CS. Chakhtoura M, et al. EClinicalMedicine. 2023 Mar 20;58:101882. doi: 10.1016/j.eclinm.2023.101882. eCollection 2023 Apr. EClinicalMedicine. 2023. PMID: 36992862 Free PMC article. Review.
Medical weight management remains one of the options for the treatment of excess weight and recent advances have revolutionized how we treat, and more importantly how we will be treating obesity in the near future. Metreleptin and Setmelanotide are currently indicated for …
Medical weight management remains one of the options for the treatment of excess weight and recent advances have revolutionized how we treat …
Metreleptin Robustly Increases Resting-state Brain Connectivity in Treatment-naive Female Patients With Lipodystrophy.
Schlögl H, Villringer A, Miehle K, Fasshauer M, Stumvoll M, Mueller K. Schlögl H, et al. J Endocr Soc. 2023 Jun 6;7(8):bvad072. doi: 10.1210/jendso/bvad072. eCollection 2023 Jul 3. J Endocr Soc. 2023. PMID: 37404242 Free PMC article.
DESIGN: Measurements in 4 female patients with LD undergoing metreleptin treatment and 3 healthy untreated controls were performed at 4 different time points over 12 weeks. ...CONCLUSIONS: Investigating brain connectivity alterations with metreleptin treatment using …
DESIGN: Measurements in 4 female patients with LD undergoing metreleptin treatment and 3 healthy untreated controls were performed at …
Lipodystrophy Syndromes.
Hussain I, Garg A. Hussain I, et al. Endocrinol Metab Clin North Am. 2016 Dec;45(4):783-797. doi: 10.1016/j.ecl.2016.06.012. Epub 2016 Oct 6. Endocrinol Metab Clin North Am. 2016. PMID: 27823605 Free PMC article. Review.
Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy.
Meehan CA, Cochran E, Kassai A, Brown RJ, Gorden P. Meehan CA, et al. Expert Rev Clin Pharmacol. 2016;9(1):59-68. doi: 10.1586/17512433.2016.1096772. Epub 2015 Oct 14. Expert Rev Clin Pharmacol. 2016. PMID: 26465174 Free PMC article. Review.
Herein we describe the properties of metreleptin, its use in patients, which includes the administration of the drug and how it may be acquired by medical professionals as well as its safety, tolerability, and properties. Finally, we speculate on future uses and developmen …
Herein we describe the properties of metreleptin, its use in patients, which includes the administration of the drug and how it may b …
234 results

Searches related to "metreleptin"