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Chlorocresol, an additive to commercial succinylcholine, induces contracture of human malignant hyperthermia-susceptible muscles via activation of the ryanodine receptor Ca2+ channel.
Tegazzin V, Scutari E, Treves S, Zorzato F. Tegazzin V, et al. Anesthesiology. 1996 Jun;84(6):1380-5. doi: 10.1097/00000542-199606000-00014. Anesthesiology. 1996. PMID: 8669679 Free article.
This study tested whether the functional properties of the Ry1 receptor Ca2+ channel are affected by chlorocresol, a preservative added to a commercial preparation of succinylcholine (Midarine) and other parenteral compounds. METHODS: In vitro contracture testing was carri …
This study tested whether the functional properties of the Ry1 receptor Ca2+ channel are affected by chlorocresol, a preservative added to a …