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Showing results for mitostatin
Your search for mikostatin retrieved no results
Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition.
Cerqua C, Anesti V, Pyakurel A, Liu D, Naon D, Wiche G, Baffa R, Dimmer KS, Scorrano L. Cerqua C, et al. EMBO Rep. 2010 Nov;11(11):854-60. doi: 10.1038/embor.2010.151. Epub 2010 Oct 8. EMBO Rep. 2010. PMID: 20930847 Free PMC article.
Trichoplein/mitostatin (TpMs) is a keratin-binding protein that partly colocalizes with mitochondria and is often downregulated in epithelial cancers, but its function remains unclear. ...
Trichoplein/mitostatin (TpMs) is a keratin-binding protein that partly colocalizes with mitochondria and is often downregulated in ep …
Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells.
Fassan M, D'Arca D, Letko J, Vecchione A, Gardiman MP, McCue P, Wildemore B, Rugge M, Shupp-Byrne D, Gomella LG, Morrione A, Iozzo RV, Baffa R. Fassan M, et al. PLoS One. 2011 May 6;6(5):e19771. doi: 10.1371/journal.pone.0019771. PLoS One. 2011. PMID: 21573075 Free PMC article.
Mitostatin negatively affects cell growth, induces cell death and regulates the expression and activation levels of Hsp27. ...Moreover, Mitostatin inhibited colony formation in soft-agar of PC3 and LNCaP cells as well as tumorigenicity of LNCaP cells in nude mice. . …
Mitostatin negatively affects cell growth, induces cell death and regulates the expression and activation levels of Hsp27. ...Moreove …
MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer.
Vecchione A, Fassan M, Anesti V, Morrione A, Goldoni S, Baldassarre G, Byrne D, D'Arca D, Palazzo JP, Lloyd J, Scorrano L, Gomella LG, Iozzo RV, Baffa R. Vecchione A, et al. Oncogene. 2009 Jan 15;28(2):257-69. doi: 10.1038/onc.2008.381. Epub 2008 Oct 20. Oncogene. 2009. PMID: 18931701 Free PMC article.
In this study, we report the cloning and functional characterization of a novel mitochondrial protein with tumor suppressor activity, henceforth designated MITOSTATIN. Human MITOSTATIN was found within a 3.2-kb transcript, which encoded a approximately 62 kDa, ubiqu …
In this study, we report the cloning and functional characterization of a novel mitochondrial protein with tumor suppressor activity, hencef …
The Role of Decorin Proteoglycan in Mitophagy.
Neill T, Iozzo RV. Neill T, et al. Cancers (Basel). 2022 Feb 4;14(3):804. doi: 10.3390/cancers14030804. Cancers (Basel). 2022. PMID: 35159071 Free PMC article. Review.
Soluble decorin evokes protracted endothelial cell autophagy via Peg3 and breast carcinoma cell mitophagy via mitostatin by interacting with VEGFR2 or the MET receptor tyrosine kinase, respectively. ...
Soluble decorin evokes protracted endothelial cell autophagy via Peg3 and breast carcinoma cell mitophagy via mitostatin by interacti …
Telomere Dysfunction Is Associated with Altered DNA Organization in Trichoplein/Tchp/Mitostatin (TpMs) Depleted Cells.
Lauriola A, Davalli P, Marverti G, Caporali A, Mai S, D'Arca D. Lauriola A, et al. Biomedicines. 2022 Jul 5;10(7):1602. doi: 10.3390/biomedicines10071602. Biomedicines. 2022. PMID: 35884905 Free PMC article.
Recently, we highlighted a novel role for the protein Trichoplein/TCHP/Mitostatin (TpMs), both as mitotic checkpoint regulator and guardian of chromosomal stability. ...
Recently, we highlighted a novel role for the protein Trichoplein/TCHP/Mitostatin (TpMs), both as mitotic checkpoint regulator and gu …
Proteoglycan-driven Autophagy: A Nutrient-independent Mechanism to Control Intracellular Catabolism.
Neill T, Buraschi S, Kapoor A, Iozzo RV. Neill T, et al. J Histochem Cytochem. 2020 Nov;68(11):733-746. doi: 10.1369/0022155420937370. Epub 2020 Jul 6. J Histochem Cytochem. 2020. PMID: 32623955 Free PMC article. Review.
These potent matrix-derived cues transduce key biological information via receptor binding to converge upon a newly discovered nexus of core autophagic machinery comprised of Peg3 (paternally expressed gene 3) for autophagy or mitostatin for mitophagy. Here, we give a mech …
These potent matrix-derived cues transduce key biological information via receptor binding to converge upon a newly discovered nexus of core …
Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and mitostatin.
Neill T, Torres A, Buraschi S, Owens RT, Hoek JB, Baffa R, Iozzo RV. Neill T, et al. J Biol Chem. 2014 Feb 21;289(8):4952-68. doi: 10.1074/jbc.M113.512566. Epub 2014 Jan 8. J Biol Chem. 2014. PMID: 24403067 Free PMC article.
We found a rapid and dynamic interplay between peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and the decorin-induced tumor suppressor gene, mitostatin. This interaction stabilized mitostatin mRNA with concurrent accumulation of …
We found a rapid and dynamic interplay between peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and the deco …
Decorin is a devouring proteoglycan: Remodeling of intracellular catabolism via autophagy and mitophagy.
Buraschi S, Neill T, Iozzo RV. Buraschi S, et al. Matrix Biol. 2019 Jan;75-76:260-270. doi: 10.1016/j.matbio.2017.10.005. Epub 2017 Nov 7. Matrix Biol. 2019. PMID: 29080840 Free PMC article. Review.
Soluble matrix-derived cues being transduced downstream of receptor engagement converge upon a newly-discovered nexus of autophagic machinery consisting of Peg3 for endothelial cell autophagy and mitostatin for tumor cell mitophagy. In this thematic mini-review, we will pr …
Soluble matrix-derived cues being transduced downstream of receptor engagement converge upon a newly-discovered nexus of autophagic machiner …
Mitochondrial fusion protein MFN2 interacts with the mitostatin-related protein MNS1 required for mouse sperm flagellar structure and function.
Vadnais ML, Lin AM, Gerton GL. Vadnais ML, et al. Cilia. 2014 May 29;3:5. doi: 10.1186/2046-2530-3-5. eCollection 2014. Cilia. 2014. PMID: 24876927 Free PMC article.
To explore the possible functions of MNS1, we performed a BLAST search and determined it is homologous to the conserved domain pfam13868, exemplified by mitostatin. This protein interacts with mitofusin 2 (MFN2), a protein that participates in regulating mitochondrial asso …
To explore the possible functions of MNS1, we performed a BLAST search and determined it is homologous to the conserved domain pfam13868, ex …
Oncosuppressive functions of decorin.
Neill T, Schaefer L, Iozzo RV. Neill T, et al. Mol Cell Oncol. 2015 Feb 25;2(3):e975645. doi: 10.4161/23723556.2014.975645. eCollection 2015 Jul-Sep. Mol Cell Oncol. 2015. PMID: 27308453 Free PMC article. Review.
15 results