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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 8
2005 1
2007 8
2008 2
2009 3
2012 1
2013 1
2017 2
2019 1
2021 1
2022 1
2023 4
2024 0

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(61)Cu-Labelled radiodiagnostics of melanoma with NAPamide-targeted radiopharmaceutical.
Kálmán-Szabó I, Bunda S, Lihi N, Szaniszló Z, Szikra D, Szabó Péliné J, Fekete A, Gyuricza B, Szücs D, Papp G, Trencsényi G, Kálmán FK. Kálmán-Szabó I, et al. Int J Pharm. 2023 Feb 5;632:122527. doi: 10.1016/j.ijpharm.2022.122527. Epub 2022 Dec 23. Int J Pharm. 2023. PMID: 36566825
Based on literature data, the radio labelled alpha-MSH analog NAPamide molecule is an appropriate diagnostic tool for the detection of melanoma tumors. Inspired by these facts, a new radiotracer, the [(61)Cu]Cu-KFTG-NAPamide has been synthesized to exploit the benef …
Based on literature data, the radio labelled alpha-MSH analog NAPamide molecule is an appropriate diagnostic tool for the detection o …
[18F]FB-(Ac-NIe-Asp-His-d-Phe-Arg-Trp-Gly-Lys-NH2).
Cheng KT, Gambhir S, Cheng Z. Cheng KT, et al. 2007 Aug 2 [updated 2007 Aug 10]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2007 Aug 2 [updated 2007 Aug 10]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641724 Free Books & Documents. Review.
[(18)F]FB-(Ac-NIe-Asp-His-d-Phe-Arg-Trp-Gly-Lys-NH(2)) ([(18)F]FB-NAPamide) is a radioligand developed as a positron emission tomography (PET) imaging probe for primary and metastatic melanoma (1). [(18)F]FB-NAPamide is an alpha-melanocytestimulating hormone (MSH) p …
[(18)F]FB-(Ac-NIe-Asp-His-d-Phe-Arg-Trp-Gly-Lys-NH(2)) ([(18)F]FB-NAPamide) is a radioligand developed as a positron emission tomogra …
99mTc(CO)3-((S-Pyridin-2-ylmethyl)-Cys)-Nle-Asp-His-d-Phe-Arg-Trp-Gly-Lys-NH2.
Leung K. Leung K. 2013 Jan 28 [updated 2013 Apr 18]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2013 Jan 28 [updated 2013 Apr 18]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 23596643 Free Books & Documents. Review.
Jiang et al. (13) prepared a linear alpha-MSH analog (Cys-Nle-Asp-His-d-Phe-Arg-Trp-Gly-Lys-NH(2), (NAPamide)) containing a S-pyridin-2-ylmethyl moiety (peptide 6) at the N-terminus Cys for radiolabeling with (99m)Tc(3). (99m)Tc(CO)(3)(S-Pyridin-2-ylmethyl)-Cys)-Nle-Asp-Hi …
Jiang et al. (13) prepared a linear alpha-MSH analog (Cys-Nle-Asp-His-d-Phe-Arg-Trp-Gly-Lys-NH(2), (NAPamide)) containing a S-pyridin …
64Cu-[Ac-NIe-Asp-His-d-Phe-Arg-Trp-Gly-Lys(1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid)-NH2].
Cheng KT, Gambhir S, Cheng Z. Cheng KT, et al. 2007 Aug 10 [updated 2007 Dec 3]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2007 Aug 10 [updated 2007 Dec 3]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641698 Free Books & Documents. Review.
(64)Cu-[Ac-NIe-Asp-His-d-Phe-Arg-Trp-Gly-Lys(1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid-NH(2)] ((64)Cu-DOTA-NAPamide) is a radioligand developed as a positron emission tomography (PET) imaging probe for primary and metastatic melanoma (1). (64)Cu-DOTA- …
(64)Cu-[Ac-NIe-Asp-His-d-Phe-Arg-Trp-Gly-Lys(1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid-NH(2)] ((64)Cu-DOTA-NAPamide …
99mTc-[Cys3,4,10,d-Phe7,Arg11]α-MSH3-13.
Cheng KT, Quinn TP. Cheng KT, et al. 2007 Jan 26 [updated 2008 Jan 22]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2007 Jan 26 [updated 2008 Jan 22]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641499 Free Books & Documents. Review.
Froidevaux et al. (11) showed that the kidney uptake of a short linear DOTAalpha-MSH analog (DOTA-NAPamide) could be considerably reduced by neutralizing the charge of the Lys(11) residue. ...
Froidevaux et al. (11) showed that the kidney uptake of a short linear DOTAalpha-MSH analog (DOTA-NAPamide) could be considerably red …
Investigation of the Effect on the Albumin Binding Moiety for the Pharmacokinetic Properties of (68)Ga-, (205/206)Bi-, and (177)Lu-Labeled NAPamide-Based Radiopharmaceuticals.
Szücs D, Szabó JP, Arató V, Gyuricza B, Szikra D, Tóth I, Képes Z, Trencsényi G, Fekete A. Szücs D, et al. Pharmaceuticals (Basel). 2023 Sep 11;16(9):1280. doi: 10.3390/ph16091280. Pharmaceuticals (Basel). 2023. PMID: 37765089 Free PMC article.
Followed by (68)Ga-, (205/206)Bi-, and (177)Lu-labelling, the radiopharmaceuticals ([(68)Ga]Ga-DOTA-IPB-NAPamide, [(205/206)Bi]Bi-DOTA-IPB-NAPamide, [(177)Lu]Lu-DOTA-IPB-NAPamide) were characterized in vitro. ...The use of albumin-binding moiety lengthened th …
Followed by (68)Ga-, (205/206)Bi-, and (177)Lu-labelling, the radiopharmaceuticals ([(68)Ga]Ga-DOTA-IPB-NAPamide, [(205/206)Bi]Bi-DOT …
Preclinical evaluation of melanocortin-1 receptor (MC1-R) specific (68)Ga- and (44)Sc-labeled DOTA-NAPamide in melanoma imaging.
Nagy G, Dénes N, Kis A, Szabó JP, Berényi E, Garai I, Bai P, Hajdu I, Szikra D, Trencsényi G. Nagy G, et al. Eur J Pharm Sci. 2017 Aug 30;106:336-344. doi: 10.1016/j.ejps.2017.06.026. Epub 2017 Jun 16. Eur J Pharm Sci. 2017. PMID: 28625749
METHODS: DOTA-NAPamide was labeled with Ga-68 and Sc-44 radionuclides. The MC1-R specificity of Ga-68- and Sc-44-labeled DOTA-NAPamide was investigated in vitro and in vivo using MC1-R positive (B16-F10) and negative (A375) melanoma cell lines. ...In animal experime …
METHODS: DOTA-NAPamide was labeled with Ga-68 and Sc-44 radionuclides. The MC1-R specificity of Ga-68- and Sc-44-labeled DOTA-NAPa …
99mTc-[Ac-CCEHdFRWCKPV-NH2].
Cheng KT. Cheng KT. 2008 Apr 7 [updated 2008 Apr 30]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2008 Apr 7 [updated 2008 Apr 30]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641691 Free Books & Documents. Review.
Froidevaux et al. (13) showed that the kidney uptake of DOTA-NAPamide, a short linear DOTAalpha-MSH analog, could be considerably reduced by neutralizing the charge of the Lys(11) residue. ...
Froidevaux et al. (13) showed that the kidney uptake of DOTA-NAPamide, a short linear DOTAalpha-MSH analog, could be considerably red …
[NIe4,Asp5,d-Phe7, 67Ga/68Ga-1,4,7,10-tetraazacyclododecane-N,N’,N’’,N’’’-1,4,7,10-tetraacetic acid-Lys11]-α-MSH4-11.
Cheng KT. Cheng KT. 2007 Jul 30 [updated 2007 Nov 19]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2007 Jul 30 [updated 2007 Nov 19]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641555 Free Books & Documents. Review.
To improve the tumor/kidney uptake ratio, the same group of researchers designed a short linear alpha-MSH analog, NAPamide, with a net charge of +1 and DOTA conjugated to the C-terminal lysine (1). They radiolabeled DOTA-NAPamide with either (67)Ga or (68)Ga as a po …
To improve the tumor/kidney uptake ratio, the same group of researchers designed a short linear alpha-MSH analog, NAPamide, with a ne …
Increasing molar activity by HPLC purification improves 68Ga-DOTA-NAPamide tumor accumulation in a B16/F1 melanoma xenograft model.
von Hacht JL, Erdmann S, Niederstadt L, Prasad S, Wagener A, Exner S, Beindorff N, Brenner W, Grötzinger C. von Hacht JL, et al. PLoS One. 2019 Jun 4;14(6):e0217883. doi: 10.1371/journal.pone.0217883. eCollection 2019. PLoS One. 2019. PMID: 31163066 Free PMC article.
Aim of this study was to compare a standard labeling protocol against the 68Ga-DOTA peptide purified from the excess of unlabeled peptide. PROCEDURES: The MC1R ligand DOTA-NAPamide was labeled with 68Ga using a standard clinical protocol. ...RESULTS: In biodistribution stu …
Aim of this study was to compare a standard labeling protocol against the 68Ga-DOTA peptide purified from the excess of unlabeled peptide. P …
24 results