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Showing results for ebpbeta
Your search for nebibeta retrieved no results
C/EBPbeta/AEP Signaling Drives Alzheimer's Disease Pathogenesis.
Xiong J, Zhang Z, Ye K. Xiong J, et al. Neurosci Bull. 2023 Jul;39(7):1173-1185. doi: 10.1007/s12264-023-01025-w. Epub 2023 Feb 3. Neurosci Bull. 2023. PMID: 36735152 Review.
Most recently, we reported that follicle-stimulating hormone (FSH) promotes AD pathology and enhances cognitive dysfunctions via activating the CCAAT-enhancer-binding protein (C/EBPbeta)/asparagine endopeptidase (AEP) pathway. This review summarizes our current understandi …
Most recently, we reported that follicle-stimulating hormone (FSH) promotes AD pathology and enhances cognitive dysfunctions via activating …
C/EBPbeta: The structure, regulation, and its roles in inflammation-related diseases.
Ren Q, Liu Z, Wu L, Yin G, Xie X, Kong W, Zhou J, Liu S. Ren Q, et al. Biomed Pharmacother. 2023 Dec 31;169:115938. doi: 10.1016/j.biopha.2023.115938. Epub 2023 Nov 24. Biomed Pharmacother. 2023. PMID: 38000353 Free article. Review.
C/EBPbeta has been involved in inflammatory responses by mediating several signaling pathways, such as MAPK/NF-kappaB and IL-6/JAK/STAT3 pathways. ...Here, we comprehensively discuss the structure and biological effects of C/EBPbeta and its role in inflammatory dise …
C/EBPbeta has been involved in inflammatory responses by mediating several signaling pathways, such as MAPK/NF-kappaB and IL-6/JAK/ST …
Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPbeta in Microglia.
Ndoja A, Reja R, Lee SH, Webster JD, Ngu H, Rose CM, Kirkpatrick DS, Modrusan Z, Chen YJ, Dugger DL, Gandham V, Xie L, Newton K, Dixit VM. Ndoja A, et al. Cell. 2020 Sep 3;182(5):1156-1169.e12. doi: 10.1016/j.cell.2020.07.011. Epub 2020 Aug 13. Cell. 2020. PMID: 32795415 Free article.
The transcription factor CCAAT/enhancer binding protein beta (c/EBPbeta) regulates pro-inflammatory genes in microglia and is upregulated in AD. We show expression of c/EBPbeta in microglia is regulated post-translationally by the ubiquitin ligase COP1 (also called …
The transcription factor CCAAT/enhancer binding protein beta (c/EBPbeta) regulates pro-inflammatory genes in microglia and is upregul …
High-fat diet-induced diabetes couples to Alzheimer's disease through inflammation-activated C/EBPbeta/AEP pathway.
Liu P, Wang ZH, Kang SS, Liu X, Xia Y, Chan CB, Ye K. Liu P, et al. Mol Psychiatry. 2022 Aug;27(8):3396-3409. doi: 10.1038/s41380-022-01600-z. Epub 2022 May 11. Mol Psychiatry. 2022. PMID: 35546632 Free PMC article.
These effects are profoundly diminished when AEP is deleted from C/EBPbeta Tg mice. Chronic treatment with inflammatory lipopolysaccharide (LPS) facilitates AD pathologies and cognitive disorders in C/EBPbeta Tg but not in wild-type mice, and these deleterious effec …
These effects are profoundly diminished when AEP is deleted from C/EBPbeta Tg mice. Chronic treatment with inflammatory lipopolysacch …
SIRT2-mediated deacetylation and deubiquitination of C/EBPbeta prevents ethanol-induced liver injury.
Zhang Y, Long X, Ruan X, Wei Q, Zhang L, Wo L, Huang D, Lin L, Wang D, Xia L, Zhao Q, Liu J, Zhao Q, He M. Zhang Y, et al. Cell Discov. 2021 Oct 12;7(1):93. doi: 10.1038/s41421-021-00326-6. Cell Discov. 2021. PMID: 34642310 Free PMC article.
Importantly, hepatic deacetylated C/EBPbeta and LCN2 compensation reversed SIRT2 deletion-induced ALD aggravation in mice. ...Therefore, activating SIRT2-C/EBPbeta-LCN2 signaling pathway is a potential therapy for ALD....
Importantly, hepatic deacetylated C/EBPbeta and LCN2 compensation reversed SIRT2 deletion-induced ALD aggravation in mice. ...Therefo …
Sepsis-induced endothelial dysfunction drives acute-on-chronic liver failure through Angiopoietin-2-HGF-C/EBPbeta pathway.
Elias G, Schonfeld M, Saleh S, Parrish M, Barmanova M, Weinman SA, Tikhanovich I. Elias G, et al. Hepatology. 2023 Sep 1;78(3):803-819. doi: 10.1097/HEP.0000000000000354. Epub 2023 Mar 22. Hepatology. 2023. PMID: 36943063
These changes were associated with reduced metabolic gene expression and increased CCAAT enhancer binding protein beta (C/EBPbeta) transcriptional activity. We found that C/EBPbeta binding to its target gene promoters was increased. ...Angiopoietin-1 supplementation …
These changes were associated with reduced metabolic gene expression and increased CCAAT enhancer binding protein beta (C/EBPbeta) tr …
Emerging functions of C/EBPbeta in breast cancer.
Matherne MG, Phillips ES, Embrey SJ, Burke CM, Machado HL. Matherne MG, et al. Front Oncol. 2023 Jan 25;13:1111522. doi: 10.3389/fonc.2023.1111522. eCollection 2023. Front Oncol. 2023. PMID: 36761942 Free PMC article. Review.
In addition, C/EBPbeta has well-established roles in mammary gland development, is overexpressed in breast cancer, and has tumor-promoting functions. ...We present challenges in C/EBPbeta biology and discuss the importance of C/EBPbeta isoform-specific gene r …
In addition, C/EBPbeta has well-established roles in mammary gland development, is overexpressed in breast cancer, and has tumor-prom …
TGF-beta-induced alpha-SMA expression is mediated by C/EBPbeta acetylation in human alveolar epithelial cells.
Ding H, Chen J, Qin J, Chen R, Yi Z. Ding H, et al. Mol Med. 2021 Mar 4;27(1):22. doi: 10.1186/s10020-021-00283-6. Mol Med. 2021. PMID: 33663392 Free PMC article.
The luciferase activity was used to examine the activity of C/EBPbeta. Knockdown of C/EBPbeta was performed by siRNA. We also investigated the effect of deacetylation of C/EBPbeta on EMT using sirtuin 1 (SIRT1). ...CONCLUSION: The EMT and fibrotic effect of T …
The luciferase activity was used to examine the activity of C/EBPbeta. Knockdown of C/EBPbeta was performed by siRNA. We also …
C/EBPbeta/AEP signaling couples atherosclerosis to the pathogenesis of Alzheimer's disease.
Liao J, Chen G, Liu X, Wei ZZ, Yu SP, Chen Q, Ye K. Liao J, et al. Mol Psychiatry. 2022 Jul;27(7):3034-3046. doi: 10.1038/s41380-022-01556-0. Epub 2022 Apr 14. Mol Psychiatry. 2022. PMID: 35422468 Free PMC article.
Here we show that C/EBPbeta/AEP pathway mediates ATH pathology and couples ATH to AD. ...Hence, our findings demonstrate that C/EBPbeta/AEP signaling couples ATH to AD via mediating vascular pathology....
Here we show that C/EBPbeta/AEP pathway mediates ATH pathology and couples ATH to AD. ...Hence, our findings demonstrate that C/EB …
C/EBPbeta sustains the oncogenic program of AML cells by cooperating with MYB and co-activator p300 in a transcriptional module.
Klempnauer KH. Klempnauer KH. Exp Hematol. 2022 Apr;108:8-15. doi: 10.1016/j.exphem.2022.01.003. Epub 2022 Jan 13. Exp Hematol. 2022. PMID: 35032593 Free article. Review.
Studies aiming to identify potential MYB inhibitors have found that the natural compound helenalin acetate (HA) inhibits viability and induces cell death and differentiation of AML cells by disrupting the MYB-induced gene expression program. Interestingly, CCAAT-box/enhancer bind …
Studies aiming to identify potential MYB inhibitors have found that the natural compound helenalin acetate (HA) inhibits viability and induc …
2,913 results