Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1983 4
1984 3
1985 1
1986 2
1987 5
1988 5
1989 5
1990 9
1991 4
1992 17
1993 13
1994 21
1995 24
1996 22
1997 18
1998 22
1999 28
2000 28
2001 28
2002 36
2003 36
2004 28
2005 45
2006 32
2007 35
2008 47
2009 29
2010 42
2011 49
2012 51
2013 41
2014 40
2015 44
2016 37
2017 35
2018 27
2019 41
2020 34
2021 40
2022 41
2023 38
2024 12

Text availability

Article attribute

Article type

Publication date

Search Results

1,016 results

Results by year

Filters applied: . Clear all
Page 1
The Human Glyoxalase Gene Family in Health and Disease.
Farrera DO, Galligan JJ. Farrera DO, et al. Chem Res Toxicol. 2022 Oct 17;35(10):1766-1776. doi: 10.1021/acs.chemrestox.2c00182. Epub 2022 Sep 1. Chem Res Toxicol. 2022. PMID: 36048613 Free PMC article. Review.
The glyoxalase gene family consists of six structurally and functionally diverse enzymes with broad roles in metabolism. ...A central function of this family is the detoxification of reactive dicarbonyls (e.g., methylglyoxal), which react with cellular nucleophiles, …
The glyoxalase gene family consists of six structurally and functionally diverse enzymes with broad roles in metabolism. ...A central …
UDP-glucuronosyltransferases.
King CD, Rios GR, Green MD, Tephly TR. King CD, et al. Curr Drug Metab. 2000 Sep;1(2):143-61. doi: 10.2174/1389200003339171. Curr Drug Metab. 2000. PMID: 11465080 Review.
At this time, over 35 different UGT gene products have been described from several different species. ...The substrate specificities of the various isoforms have been examined in cultured cell experiments, and include bilirubin, amines, and planar and bulky phenol. The UGT …
At this time, over 35 different UGT gene products have been described from several different species. ...The substrate specificities …
Mutations in the LMNA gene encoding lamin A/C.
Genschel J, Schmidt HH. Genschel J, et al. Hum Mutat. 2000 Dec;16(6):451-9. doi: 10.1002/1098-1004(200012)16:6<451::AID-HUMU1>3.0.CO;2-9. Hum Mutat. 2000. PMID: 11102973 Review.
The LMNA gene encodes for the nucleophilic A-type lamins, lamin A and lamin C. These isoforms are generated by different splicing within exon 10 of LMNA. Thus lamin A/C is, besides emerin, the first known nucleophilic protein which plays a role in human disea …
The LMNA gene encodes for the nucleophilic A-type lamins, lamin A and lamin C. These isoforms are generated by different splic …
New nucleophilic mechanisms of ros-dependent epigenetic modifications: comparison of aging and cancer.
Afanas'ev I. Afanas'ev I. Aging Dis. 2013 Oct 21;5(1):52-62. doi: 10.14336/AD.2014.050052. eCollection 2014 Feb. Aging Dis. 2013. PMID: 24490117 Free PMC article. Review.
However, being "super-nucleophile" superoxide can participate in these reactions. Now we propose new nucleophilic mechanisms of DNA methylation and histone modification. ...In cancer cells ROS enhance DNA methylation causing the silencing of tumor suppressor and ant …
However, being "super-nucleophile" superoxide can participate in these reactions. Now we propose new nucleophilic mechanisms o …
Reactive-cysteine profiling for drug discovery.
Maurais AJ, Weerapana E. Maurais AJ, et al. Curr Opin Chem Biol. 2019 Jun;50:29-36. doi: 10.1016/j.cbpa.2019.02.010. Epub 2019 Mar 18. Curr Opin Chem Biol. 2019. PMID: 30897495 Free PMC article. Review.
The recognition that only a small percentage of known human gene products are druggable using traditional modes of non-covalent ligand design, has led to a resurgence in targeted covalent inhibitors. ...Reactive cysteine residues on proteins are a common target for covalen …
The recognition that only a small percentage of known human gene products are druggable using traditional modes of non-covalent ligan …
Endocannabinoid hydrolases.
Ueda N. Ueda N. Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:521-34. doi: 10.1016/s0090-6980(02)00053-9. Prostaglandins Other Lipid Mediat. 2002. PMID: 12432941 Review.
This enzyme has a broad substrate specificity, hydrolyzing oleamide (an endogenous sleep-inducing factor) and 2-AG as well as anandamide. cDNA cloning revealed that FAAH is composed of 579 amino acids and belongs to the amidase signature family. A serine residue functioning as a …
This enzyme has a broad substrate specificity, hydrolyzing oleamide (an endogenous sleep-inducing factor) and 2-AG as well as anandamide. cD …
Nucleophilic 1,4-additions for natural product discovery.
Cox CL, Tietz JI, Sokolowski K, Melby JO, Doroghazi JR, Mitchell DA. Cox CL, et al. ACS Chem Biol. 2014 Sep 19;9(9):2014-22. doi: 10.1021/cb500324n. Epub 2014 Jun 17. ACS Chem Biol. 2014. PMID: 24937678 Free PMC article.
Our strategy entails the use of a commercially available thiol, dithiothreitol, for the covalent labeling of activated alkenes by nucleophilic 1,4-addition. Modification is easily discerned by comparing mass spectra of reacted and unreacted cell surface extracts. When comb …
Our strategy entails the use of a commercially available thiol, dithiothreitol, for the covalent labeling of activated alkenes by nucleop …
Serine carboxypeptidase-like acyltransferases.
Milkowski C, Strack D. Milkowski C, et al. Phytochemistry. 2004 Mar;65(5):517-24. doi: 10.1016/j.phytochem.2003.12.018. Phytochemistry. 2004. PMID: 15003414 Review.
SCPL acyltransferases belong to the highly divergent class of alpha/beta hydrolases. These enzymes make use of a catalytic triad formed by a nucleophile, an acid and histidine acting as a charge relay system for the nucleophilic attack on amide or ester bonds. ...SC …
SCPL acyltransferases belong to the highly divergent class of alpha/beta hydrolases. These enzymes make use of a catalytic triad formed by a …
How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo.
Forman HJ, Davies KJ, Ursini F. Forman HJ, et al. Free Radic Biol Med. 2014 Jan;66:24-35. doi: 10.1016/j.freeradbiomed.2013.05.045. Epub 2013 Jun 6. Free Radic Biol Med. 2014. PMID: 23747930 Free PMC article. Review.
Furthermore, we propose that a major mechanism of action for nutritional antioxidants is the paradoxical oxidative activation of the Nrf2 (NF-E2-related factor 2) signaling pathway, which maintains protective oxidoreductases and their nucleophilic substrates. This maintena …
Furthermore, we propose that a major mechanism of action for nutritional antioxidants is the paradoxical oxidative activation of the Nrf2 (N …
Overcoming differences: The catalytic mechanism of metallo-β-lactamases.
Meini MR, Llarrull LI, Vila AJ. Meini MR, et al. FEBS Lett. 2015 Nov 14;589(22):3419-32. doi: 10.1016/j.febslet.2015.08.015. Epub 2015 Aug 20. FEBS Lett. 2015. PMID: 26297824 Free PMC article. Review.
We propose that these enzymes present a modular structure in their active sites that can be dissected into two halves: one providing the attacking nucleophile, and the second one stabilizing a negatively charged reaction intermediate. These are common mechanistic elements …
We propose that these enzymes present a modular structure in their active sites that can be dissected into two halves: one providing the att …
1,016 results