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Showing results for olanzapine vagal
Your search for olanzapina-vegal retrieved no results
Olanzapine-activated AMPK signaling in the dorsal vagal complex is attenuated by histamine H1 receptor agonist in female rats.
He M, Zhang Q, Deng C, Wang H, Huang XF. He M, et al. Endocrinology. 2014 Dec;155(12):4895-904. doi: 10.1210/en.2014-1326. Epub 2014 Sep 29. Endocrinology. 2014. PMID: 25264935
The present study investigated the time-dependent effect of olanzapine treatment (8, 16, and 36 d) on DVC AMPK signaling in olanzapine-induced weight gain and whether these changes are associated with olanzapine-induced H1 receptor antagonism. ...These result …
The present study investigated the time-dependent effect of olanzapine treatment (8, 16, and 36 d) on DVC AMPK signaling in olanza …
Olanzapine Administration Reduces Chemotherapy-Induced Nausea Behavior in Rats.
Jaime-Lara RB, Borner T, Holland RA, Shaulson E, Brooks B, De Jonghe BC. Jaime-Lara RB, et al. Biol Res Nurs. 2021 Oct;23(4):584-595. doi: 10.1177/10998004211000443. Epub 2021 Apr 1. Biol Res Nurs. 2021. PMID: 33789505 Free PMC article.
Nausea and vomiting are consistently identified among the most distressing side effects of chemotherapy. In recent years, Olanzapine (OLZ) treatment was added to anti-emetic guidelines as a treatment for chemotherapy-induced nausea and vomiting (CINV), despite little avail …
Nausea and vomiting are consistently identified among the most distressing side effects of chemotherapy. In recent years, Olanzapine …
The effects of antipsychotics on the density of cannabinoid receptors in the dorsal vagal complex of rats: implications for olanzapine-induced weight gain.
Weston-Green K, Huang XF, Han M, Deng C. Weston-Green K, et al. Int J Neuropsychopharmacol. 2008 Sep;11(6):827-35. doi: 10.1017/S1461145708008560. Epub 2008 Feb 7. Int J Neuropsychopharmacol. 2008. PMID: 18257959 Free article.
Some atypical antipsychotics clinically used to treat schizophrenia induce weight gain by unknown mechanisms. The dorsal vagal complex (DVC) of the brainstem and the endogenous cannabinoid system are implicated in the regulation of appetite signalling and food intake. ...F …
Some atypical antipsychotics clinically used to treat schizophrenia induce weight gain by unknown mechanisms. The dorsal vagal comple …
Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone levels.
Weston-Green K, Huang XF, Lian J, Deng C. Weston-Green K, et al. Eur Neuropsychopharmacol. 2012 May;22(5):364-73. doi: 10.1016/j.euroneuro.2011.09.003. Epub 2011 Oct 6. Eur Neuropsychopharmacol. 2012. PMID: 21982116
Increased M3R density is a compensatory up-regulation in response to olanzapine's M3R antagonism. Olanzapine acts on M3R in regions of the brain that control food intake and insulin secretion. Olanzapine's M3R blockade in the brain may inhibit t …
Increased M3R density is a compensatory up-regulation in response to olanzapine's M3R antagonism. Olanzapine acts on M3 …
Olanzapine treatment decreases the density of muscarinic M2 receptors in the dorsal vagal complex of rats.
Deng C, Weston-Green KL, Han M, Huang XF. Deng C, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2007 May 9;31(4):915-20. doi: 10.1016/j.pnpbp.2007.02.009. Epub 2007 Feb 20. Prog Neuropsychopharmacol Biol Psychiatry. 2007. PMID: 17368684
In this study, we investigated the effects of antipsychotic drugs, olanzapine and haloperidol, on the density of the muscarinic M2 receptors in the dorsal vagal complex (DVC) and hypoglossal nucleus (HN). Female Sprague Dawley rats were treated with olanzapine …
In this study, we investigated the effects of antipsychotic drugs, olanzapine and haloperidol, on the density of the muscarinic M2 re …
Brain stem as a target site for the metabolic side effects of olanzapine.
Anwar IJ, Miyata K, Zsombok A. Anwar IJ, et al. J Neurophysiol. 2016 Mar;115(3):1389-98. doi: 10.1152/jn.00387.2015. Epub 2015 Dec 30. J Neurophysiol. 2016. PMID: 26719086 Free PMC article.
Our study demonstrates that olanzapine has a powerful effect on DMV neurons in both sexes, indicating its ability to reduce vagal output to the subdiaphragmatic organs, which likely contributes to the metabolic side effects observed in both humans and experimental m …
Our study demonstrates that olanzapine has a powerful effect on DMV neurons in both sexes, indicating its ability to reduce vagal …
Alterations to melanocortinergic, GABAergic and cannabinoid neurotransmission associated with olanzapine-induced weight gain.
Weston-Green K, Huang XF, Deng C. Weston-Green K, et al. PLoS One. 2012;7(3):e33548. doi: 10.1371/journal.pone.0033548. Epub 2012 Mar 16. PLoS One. 2012. PMID: 22438946 Free PMC article.
METHODOLOGY/RESULTS: Levels of pro-opiomelanocortin (POMC), neuropeptide Y (NPY) and glutamic acid decarboxylase (GAD(65), enzyme for GABA synthesis) mRNA expression, and cannabinoid CB1 receptor (CB1R) binding density (using [(3)H]SR-141716A) were examined in the arcuate nucleus …
METHODOLOGY/RESULTS: Levels of pro-opiomelanocortin (POMC), neuropeptide Y (NPY) and glutamic acid decarboxylase (GAD(65), enzyme for GABA s …
A case of sinus pause induced by swallowing in the setting of olanzapine and guanfacine overdose.
Kolarich AR, Mubarak M, Wells S, Campbell CT, Samraj RS. Kolarich AR, et al. J Intensive Care Soc. 2019 Aug;20(3):277-280. doi: 10.1177/1751143718786109. Epub 2018 Jul 5. J Intensive Care Soc. 2019. PMID: 31447925 Free PMC article.
We present a unique case of a 17-year-old male who overdosed on 340 mg of olanzapine and 189 mg of extended-release guanfacine with a previously unreported adverse event. Specifically, five days after ingestion, he developed a 5-8 s sinus pause every time he forcefully swa …
We present a unique case of a 17-year-old male who overdosed on 340 mg of olanzapine and 189 mg of extended-release guanfacine with a …
Second generation antipsychotic-induced type 2 diabetes: a role for the muscarinic M3 receptor.
Weston-Green K, Huang XF, Deng C. Weston-Green K, et al. CNS Drugs. 2013 Dec;27(12):1069-80. doi: 10.1007/s40263-013-0115-5. CNS Drugs. 2013. PMID: 24114586 Review.
Studies have identified that SGA binding affinity to the M3R is a predictor of diabetes risk; indeed, olanzapine and clozapine, SGAs with the highest clinical incidence of diabetes side-effects, are potent M3R antagonists. ...Genetic modification of M3Rs causes robust alte …
Studies have identified that SGA binding affinity to the M3R is a predictor of diabetes risk; indeed, olanzapine and clozapine, SGAs …
Cardiovascular variability during treatment with haloperidol, olanzapine or risperidone in recent-onset schizophrenia.
Hempel RJ, Tulen JH, van Beveren NJ, Röder CH, Hengeveld MW. Hempel RJ, et al. J Psychopharmacol. 2009 Aug;23(6):697-707. doi: 10.1177/0269881108091254. Epub 2008 Jun 18. J Psychopharmacol. 2009. PMID: 18562420
This study aimed to investigate the effects of treatment with haloperidol, olanzapine and risperidone on cardiovascular variability in patients with recent-onset schizophrenia by means of spectral analysis. Unmedicated patients (n = 18) had a higher mean heart rate and a t …
This study aimed to investigate the effects of treatment with haloperidol, olanzapine and risperidone on cardiovascular variability i …
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