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Omacetaxine.
[No authors listed] [No authors listed] 2017 Jan 6. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. 2012–. PMID: 31643365 Free Books & Documents. Review.
Omacetaxine is a semisynthetic cephataxine that acts as a protein translation inhibitor and is used to treated chronic myeloid leukemia that is resistant to tyrosine kinase receptor antagonists. Omacetaxine is associated with a low rate of serum enzyme elevation dur …
Omacetaxine is a semisynthetic cephataxine that acts as a protein translation inhibitor and is used to treated chronic myeloid leukem …
A Review of Omacetaxine: A Chronic Myeloid Leukemia Treatment Resurrected.
Winer ES, DeAngelo DJ. Winer ES, et al. Oncol Ther. 2018 Jun;6(1):9-20. doi: 10.1007/s40487-018-0058-6. Epub 2018 Mar 15. Oncol Ther. 2018. PMID: 32700137 Free PMC article. Review.
The advent of tyrosine kinase inhibitors (TKIs) has led to marked improvements in responses and overall survival; however, there is still a subset of patients that are either resistant through a multitude of mechanisms or intolerant to standard TKI therapy. Omacetaxine mep …
The advent of tyrosine kinase inhibitors (TKIs) has led to marked improvements in responses and overall survival; however, there is still a …
Omacetaxine Mepesuccinate for Chronic Myeloid Leukemia.
Rosshandler Y, Shen AQ, Cortes J, Khoury HJ. Rosshandler Y, et al. Expert Rev Hematol. 2016 May;9(5):419-24. doi: 10.1586/17474086.2016.1151351. Epub 2016 Apr 21. Expert Rev Hematol. 2016. PMID: 26853281 Review.
Omacetaxine mepesuccinate has distinct but manageable adverse events profile. Omacetaxine mepesuccinate is a treatment option for a subset of patients with refractory chronic myeloid leukemia....
Omacetaxine mepesuccinate has distinct but manageable adverse events profile. Omacetaxine mepesuccinate is a treatment option …
Omacetaxine mepesuccinate (synribo) - newly launched in chronic myeloid leukemia.
Nazha A, Kantarjian H, Cortes J, Quintás-Cardama A. Nazha A, et al. Expert Opin Pharmacother. 2013 Oct;14(14):1977-86. doi: 10.1517/14656566.2013.821464. Epub 2013 Jul 23. Expert Opin Pharmacother. 2013. PMID: 23875628 Review.
INTRODUCTION: Omacetaxine mepesuccinate (formerly known as homoharringtonine [HHT]) is a natural alkaloid with significant anticancer activity partly through inhibition of protein synthesis and induction of apoptosis. ...The development of an oral formulation of …
INTRODUCTION: Omacetaxine mepesuccinate (formerly known as homoharringtonine [HHT]) is a natural alkaloid with significant ant …
Exploiting Protein Translation Dependence in Multiple Myeloma with Omacetaxine-Based Therapy.
Walker ZJ, Idler BM, Davis LN, Stevens BM, VanWyngarden MJ, Ohlstrom D, Bearrows SC, Hammes A, Smith CA, Jordan CT, Mark TM, Forsberg PA, Sherbenou DW. Walker ZJ, et al. Clin Cancer Res. 2021 Feb 1;27(3):819-830. doi: 10.1158/1078-0432.CCR-20-2246. Epub 2020 Oct 27. Clin Cancer Res. 2021. PMID: 33109736
In this article, we interrogate the unique sensitivity of multiple myeloma cells to the alternative strategy of blocking protein translation with omacetaxine. EXPERIMENTAL DESIGN: We determined protein translation levels (n = 17) and sensitivity to omacetaxine (n = …
In this article, we interrogate the unique sensitivity of multiple myeloma cells to the alternative strategy of blocking protein translation …
Omacetaxine for treatment-resistant or treatment-intolerant adult chronic myeloid leukemia.
Chung C. Chung C. Am J Health Syst Pharm. 2014 Feb 15;71(4):279-88. doi: 10.2146/ajhp130506. Am J Health Syst Pharm. 2014. PMID: 24481153 Review.
Symptom improvement or improved overall survival in omacetaxine-treated patients has not been demonstrated. In clinical trials to date, the most common grade 1-4 adverse reactions included thrombocytopenia, anemia, neutropenia, diarrhea, nausea, fatigue, and asthenia. ...C …
Symptom improvement or improved overall survival in omacetaxine-treated patients has not been demonstrated. In clinical trials to dat …
Omacetaxine mepesuccinate in the treatment of intractable chronic myeloid leukemia.
Chen Y, Li S. Chen Y, et al. Onco Targets Ther. 2014 Jan 31;7:177-86. doi: 10.2147/OTT.S41786. eCollection 2014. Onco Targets Ther. 2014. PMID: 24516334 Free PMC article. Review.
In a significant proportion of patients with chronic myeloid leukemia, resistance to BCR-ABL tyrosine kinase inhibitors develops due to acquisition of BCR-ABL kinase domain mutations and insensitivity of leukemia stem cells to tyrosine kinase inhibitors. Omacetaxine mepesu …
In a significant proportion of patients with chronic myeloid leukemia, resistance to BCR-ABL tyrosine kinase inhibitors develops due to acqu …
Omacetaxine mepesuccinate in chronic myeloid leukemia.
Al Ustwani O, Griffiths EA, Wang ES, Wetzler M. Al Ustwani O, et al. Expert Opin Pharmacother. 2014 Nov;15(16):2397-405. doi: 10.1517/14656566.2014.964642. Expert Opin Pharmacother. 2014. PMID: 25301179 Review.
INTRODUCTION: Homoharringtonine (HHT) and other alkaloid esters were originally isolated from the Cephalotaxus evergreen tree and have been used in traditional Chinese medicine since the 1970s to treat a variety of malignancies. ...AREAS COVERED: In this review, we summari …
INTRODUCTION: Homoharringtonine (HHT) and other alkaloid esters were originally isolated from the Cephalotaxus evergreen tree and hav …
Omacetaxine as an anticancer therapeutic: what is old is new again.
Wetzler M, Segal D. Wetzler M, et al. Curr Pharm Des. 2011;17(1):59-64. doi: 10.2174/138161211795049778. Curr Pharm Des. 2011. PMID: 21294709 Review.
Omacetaxine mepesuccinate was originally identified more than 35 years ago and initial studies in chronic myeloid leukemia (CML) showed promising activity. ...However, the introduction of imatinib and related tyrosine kinase inhibitors (TKIs) abated the clinical developmen …
Omacetaxine mepesuccinate was originally identified more than 35 years ago and initial studies in chronic myeloid leukemia (CML) show …
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