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Page 1
Cardiogenic control of affective behavioural state.
Hsueh B, Chen R, Jo Y, Tang D, Raffiee M, Kim YS, Inoue M, Randles S, Ramakrishnan C, Patel S, Kim DK, Liu TX, Kim SH, Tan L, Mortazavi L, Cordero A, Shi J, Zhao M, Ho TT, Crow A, Yoo AW, Raja C, Evans K, Bernstein D, Zeineh M, Goubran M, Deisseroth K. Hsueh B, et al. Nature. 2023 Mar;615(7951):292-299. doi: 10.1038/s41586-023-05748-8. Epub 2023 Mar 1. Nature. 2023. PMID: 36859543 Free PMC article.
Emotional states influence bodily physiology, as exemplified in the top-down process by which anxiety causes faster beating of the heart(1-3). However, whether an increased heart rate might itself induce anxiety or fear responses is unclear(3-8). ...We identi …
Emotional states influence bodily physiology, as exemplified in the top-down process by which anxiety causes faster beating of the heart …
Optogenetic stimulation: Understanding memory and treating deficits.
Barnett SC, Perry BAL, Dalrymple-Alford JC, Parr-Brownlie LC. Barnett SC, et al. Hippocampus. 2018 Jul;28(7):457-470. doi: 10.1002/hipo.22960. Hippocampus. 2018. PMID: 29742814 Review.
Technology allowing genetically targeted cells to be modulated by light has revolutionized neuroscience in the past decade, and given rise to the field of optogenetic stimulation. For this, non-native, light activated proteins (e.g., channelrhodopsin) are expressed in a sp …
Technology allowing genetically targeted cells to be modulated by light has revolutionized neuroscience in the past decade, and given rise t …
Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats.
Rich MT, Huang YH, Torregrossa MM. Rich MT, et al. J Vis Exp. 2021 Oct 5;(176). doi: 10.3791/63185. J Vis Exp. 2021. PMID: 34694295
This protocol demonstrates the steps needed to use optogenetic tools to reverse cocaine-induced plasticity at thalamo-amygdala circuits to reduce subsequent cocaine seeking behaviors in the rat. ...Optical fibers were then implanted in the LA and 473 nm laser light was …
This protocol demonstrates the steps needed to use optogenetic tools to reverse cocaine-induced plasticity at thalamo-amygdala circui …
Potassium channel-based optogenetic silencing.
Bernal Sierra YA, Rost BR, Pofahl M, Fernandes AM, Kopton RA, Moser S, Holtkamp D, Masala N, Beed P, Tukker JJ, Oldani S, Bönigk W, Kohl P, Baier H, Schneider-Warme F, Hegemann P, Beck H, Seifert R, Schmitz D. Bernal Sierra YA, et al. Nat Commun. 2018 Nov 5;9(1):4611. doi: 10.1038/s41467-018-07038-8. Nat Commun. 2018. PMID: 30397200 Free PMC article.
Optogenetics enables manipulation of biological processes with light at high spatio-temporal resolution to control the behavior of cells, networks, or even whole animals. ...Activation of this 'PAC-K' silencer by brief pulses of low-intensity blue light causes robus …
Optogenetics enables manipulation of biological processes with light at high spatio-temporal resolution to control the behavior of ce …
A photoswitchable GPCR-based opsin for presynaptic inhibition.
Copits BA, Gowrishankar R, O'Neill PR, Li JN, Girven KS, Yoo JJ, Meshik X, Parker KE, Spangler SM, Elerding AJ, Brown BJ, Shirley SE, Ma KKL, Vasquez AM, Stander MC, Kalyanaraman V, Vogt SK, Samineni VK, Patriarchi T, Tian L, Gautam N, Sunahara RK, Gereau RW 4th, Bruchas MR. Copits BA, et al. Neuron. 2021 Jun 2;109(11):1791-1809.e11. doi: 10.1016/j.neuron.2021.04.026. Epub 2021 May 11. Neuron. 2021. PMID: 33979635 Free PMC article.
Optical manipulations of genetically defined cell types have generated significant insights into the dynamics of neural circuits. While optogenetic activation has been relatively straightforward, rapid and reversible synaptic inhibition has proven more elusive. ...PPO is a …
Optical manipulations of genetically defined cell types have generated significant insights into the dynamics of neural circuits. While o …
Cell-Type-Specific Optogenetic Techniques Reveal Neural Circuits Crucial for Episodic Memories.
Yamamoto N, Marks WD, Kitamura T. Yamamoto N, et al. Adv Exp Med Biol. 2021;1293:429-447. doi: 10.1007/978-981-15-8763-4_28. Adv Exp Med Biol. 2021. PMID: 33398831 Free PMC article.
Integrating optogenetics with drug-regulatable activity-dependent gene expression systems has identified memory engram cells, which are a subpopulation of cells that encode a specific episode. Finally, millisecond pulse stimulation of neural activity by optogenet …
Integrating optogenetics with drug-regulatable activity-dependent gene expression systems has identified memory engram cells, which a …
(2R,6R)-hydroxynorketamine rapidly potentiates optically-evoked Schaffer collateral synaptic activity.
Riggs LM, Thompson SM, Gould TD. Riggs LM, et al. Neuropharmacology. 2022 Aug 15;214:109153. doi: 10.1016/j.neuropharm.2022.109153. Epub 2022 May 31. Neuropharmacology. 2022. PMID: 35661657 Free PMC article.
We hypothesize that the rapid antidepressant actions of (2R,6R)-HNK involve an acute increase in glutamate release at Schaffer collateral synapses. Here, we used an optogenetic approach to assess whether (2R,6R)-HNK promotes glutamate release at CA1-projecting Schaffer col …
We hypothesize that the rapid antidepressant actions of (2R,6R)-HNK involve an acute increase in glutamate release at Schaffer collateral sy …
Optogenetic and chemogenetic strategies for sustained inhibition of pain.
Iyer SM, Vesuna S, Ramakrishnan C, Huynh K, Young S, Berndt A, Lee SY, Gorini CJ, Deisseroth K, Delp SL. Iyer SM, et al. Sci Rep. 2016 Aug 3;6:30570. doi: 10.1038/srep30570. Sci Rep. 2016. PMID: 27484850 Free PMC article.
Spatially targeted, genetically-specific strategies for sustained inhibition of nociceptors may help transform pain science and clinical management. Previous optogenetic strategies to inhibit pain have required constant illumination, and chemogenetic approaches in the peri …
Spatially targeted, genetically-specific strategies for sustained inhibition of nociceptors may help transform pain science and clinical man …
Septohippocampal transmission from parvalbumin-positive neurons features rapid recovery from synaptic depression.
Yi F, Garrett T, Deisseroth K, Haario H, Stone E, Lawrence JJ. Yi F, et al. Sci Rep. 2021 Jan 22;11(1):2117. doi: 10.1038/s41598-020-80245-w. Sci Rep. 2021. PMID: 33483520 Free PMC article.
Viral expression of the fast-kinetic channelrhodopsin ChETA-YFP elicited action potentials to brief (1-2 ms) 470 nm light pulses. To investigate [Formula: see text] transmission, light pulses at 5-50 Hz frequencies generated trains of inhibitory postsynaptic current …
Viral expression of the fast-kinetic channelrhodopsin ChETA-YFP elicited action potentials to brief (1-2 ms) 470 nm light pulses. To …
Cell type-specific excitability probed by optogenetic stimulation depends on the phase of the alpha oscillation.
Zhang M, Frohlich F. Zhang M, et al. Brain Stimul. 2022 Mar-Apr;15(2):472-482. doi: 10.1016/j.brs.2022.02.014. Epub 2022 Feb 25. Brain Stimul. 2022. PMID: 35219922 Free PMC article.
OBJECTIVE: We examine how the excitability of pyramidal cells and presumed fast-spiking inhibitory interneurons depends on the phase of the alpha oscillation. METHODS: Optogenetic stimulation pulses were administered at random phases of the alpha oscillation in the …
OBJECTIVE: We examine how the excitability of pyramidal cells and presumed fast-spiking inhibitory interneurons depends on the phase of the …
26 results