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397 results

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Orcinol glucoside targeted p38 as an agonist to promote osteogenesis and protect glucocorticoid-induced osteoporosis.
He XY, Zhao WL, Yao LP, Sun P, Cheng G, Liu YL, Yu Y, Liu Y, Wang TJ, Zhang QY, Qin LP, Zhang QL. He XY, et al. Phytomedicine. 2023 Oct;119:154953. doi: 10.1016/j.phymed.2023.154953. Epub 2023 Jul 26. Phytomedicine. 2023. PMID: 37573809
PURPOSE: The aim of this study was to investigate the potential effects of orcinol glucoside (OG) on osteoblast cells and GIOP mice, as well as the mechanism of the underlying molecular target protein of OG both in vitro osteoblast cell and in vivo GIOP mice model. ...
PURPOSE: The aim of this study was to investigate the potential effects of orcinol glucoside (OG) on osteoblast cells and GIOP mice, …
Orcinol and resorcinol induce local ordering of water molecules near the liquid-vapor interface.
Yang H, Gladich I, Boucly A, Artiglia L, Ammann M. Yang H, et al. Environ Sci Atmos. 2022 Aug 23;2(6):1277-1291. doi: 10.1039/d2ea00015f. eCollection 2022 Nov 10. Environ Sci Atmos. 2022. PMID: 36561553 Free PMC article.
Resorcinol and orcinol are simple members of the family of phenolic compounds present in particulate matter in the atmosphere; they are amphiphilic in nature and thus surface active in aqueous solution. Here, we used X-ray photoelectron spectroscopy to probe the concentrat …
Resorcinol and orcinol are simple members of the family of phenolic compounds present in particulate matter in the atmosphere; they a …
Orcinol Glucoside Improves Senile Osteoporosis through Attenuating Oxidative Stress and Autophagy of Osteoclast via Activating Nrf2/Keap1 and mTOR Signaling Pathway.
Gong W, Liu M, Zhang Q, Zhang Q, Wang Y, Zhao Q, Xiang L, Zheng C, Zhang Q, Qin L. Gong W, et al. Oxid Med Cell Longev. 2022 May 9;2022:5410377. doi: 10.1155/2022/5410377. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35585885 Free PMC article.
Oxidative stress and autophagy play essential roles in the development of senile osteoporosis which is characterized by disrupted osteoclastic bone resorption and osteoblastic bone formation. Orcinol glucoside (OG), a phenolic glycoside isolated from Curculigo orchioides G …
Oxidative stress and autophagy play essential roles in the development of senile osteoporosis which is characterized by disrupted osteoclast …
Orcinol glucoside improves the depressive-like behaviors of perimenopausal depression mice through modulating activity of hypothalamic-pituitary-adrenal/ovary axis and activating BDNF- TrkB-CREB signaling pathway.
Li J, He P, Zhang J, Li N. Li J, et al. Phytother Res. 2021 Oct;35(10):5795-5807. doi: 10.1002/ptr.7237. Epub 2021 Aug 11. Phytother Res. 2021. PMID: 34382261
Orcinol Glucoside (OG), a phenolic glucoside isolated from C. orchioides, showed the antidepressant-like effect on chronic unpredictable mild stress (CUMS)-induced rats previously. ...
Orcinol Glucoside (OG), a phenolic glucoside isolated from C. orchioides, showed the antidepressant-like effect on chronic unpredicta …
Production of the antidepressant orcinol glucoside in Yarrowia lipolytica with yields over 6,400-fold higher than plant extraction.
Chen B, Liu X, Wang Y, Bai J, Liu X, Xiang G, Liu W, Zhu X, Cheng J, Lu L, Zhang G, Zhang G, Dai Z, Zi S, Yang S, Jiang H. Chen B, et al. PLoS Biol. 2023 Jun 6;21(6):e3002131. doi: 10.1371/journal.pbio.3002131. eCollection 2023 Jun. PLoS Biol. 2023. PMID: 37279234 Free PMC article.
Orcinol glucoside (OG), mainly found in the rhizome of the traditional Chinese herb Curculigo orchioides Gaertn, is noted for its antidepressant effects. In this study, an efficient screening pipeline was established for identifying the highly active orcinol synthas …
Orcinol glucoside (OG), mainly found in the rhizome of the traditional Chinese herb Curculigo orchioides Gaertn, is noted for its ant …
Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/beta-catenin signaling pathway.
Zhou X, Liu Z, Huang B, Yan H, Yang C, Li Q, Jin D. Zhou X, et al. Drug Des Devel Ther. 2019 Aug 5;13:2703-2713. doi: 10.2147/DDDT.S208458. eCollection 2019. Drug Des Devel Ther. 2019. PMID: 31496649 Free PMC article. Retracted.
As a traditional Chinese medicine, Rhizoma Curculiginis (Xianmao) has been used to treat bone diseases and promote bone healing, while the effective constituent of it and the underlying mechanisms are unknown. OBJECTIVES: The aim of this study is to unveil the role of orcinol …
As a traditional Chinese medicine, Rhizoma Curculiginis (Xianmao) has been used to treat bone diseases and promote bone healing, while the e …
Orcinol derivative compound with antioxidant properties protects Langerhans islets against streptozotocin damage.
Sánchez-Lira NM, Morales-Miranda A, García de la Mora G, León Contreras JC, González-Sánchez I, Valencia N, Cerbón M, Morimoto S. Sánchez-Lira NM, et al. J Pharm Pharmacol. 2017 Mar;69(3):305-313. doi: 10.1111/jphp.12696. Epub 2017 Jan 30. J Pharm Pharmacol. 2017. PMID: 28134974
OBJECTIVE: To design and synthesize an orcinol derivative compound, 3-formyl-2,4-dihydroxy-5,6-dimethyl sodium benzoate (A4), as an antioxidant molecule and to test its effects on oxidative stress in an in-vitro model of apoptosis of pancreatic rat beta cells induced by st …
OBJECTIVE: To design and synthesize an orcinol derivative compound, 3-formyl-2,4-dihydroxy-5,6-dimethyl sodium benzoate (A4), as an a …
Orcinol gentiobioside inhibits RANKL-induced osteoclastogenesis by promoting apoptosis and suppressing autophagy via the JNK1 signaling.
Lian C, Gong W, Zhao X, Sun P, Hu S, Zhou G, Zhang Q, Qin L. Lian C, et al. J Ethnopharmacol. 2024 Jun 28;328:118060. doi: 10.1016/j.jep.2024.118060. Epub 2024 Mar 21. J Ethnopharmacol. 2024. PMID: 38521429
Curculigo orchioides Gaertn has a long history of application in traditional Chinese and Indian medicine for treating OP. Orcinol gentiobioside (OGB) is a principal active constituent derived from Curculigo orchioides Gaertn and has been shown to have anti-OP activity. ...
Curculigo orchioides Gaertn has a long history of application in traditional Chinese and Indian medicine for treating OP. Orcinol gen …
Two Novel Palbociclib-Resorcinol and Palbociclib-Orcinol Cocrystals with Enhanced Solubility and Dissolution Rate.
Duan C, Liu W, Tao Y, Liang F, Chen Y, Xiao X, Zhang G, Chen Y, Hao C. Duan C, et al. Pharmaceutics. 2021 Dec 23;14(1):23. doi: 10.3390/pharmaceutics14010023. Pharmaceutics. 2021. PMID: 35056919 Free PMC article.
In this study, two cocrystals of PAL with resorcinol (RES) or orcinol (ORC) were prepared by evaporation crystallization to enhance their solubility. ...
In this study, two cocrystals of PAL with resorcinol (RES) or orcinol (ORC) were prepared by evaporation crystallization to enhance t …
397 results

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