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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1966 1
1967 3
1968 5
1969 1
1970 5
1971 9
1972 4
1973 10
1974 12
1975 15
1976 12
1977 14
1978 6
1979 15
1980 26
1981 15
1982 15
1983 7
1984 10
1985 4
1986 7
1987 5
1988 3
1989 2
1990 2
1992 4
1993 1
1994 4
1995 3
1996 1
1997 2
1998 2
1999 6
2000 4
2001 1
2002 3
2003 6
2004 7
2005 4
2006 10
2007 5
2008 3
2009 7
2010 10
2011 19
2012 29
2013 60
2014 78
2015 103
2016 140
2017 209
2018 251
2019 294
2020 452
2021 520
2022 484
2023 499
2024 249

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3,294 results

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Page 1
Organogenesis in a dish: modeling development and disease using organoid technologies.
Lancaster MA, Knoblich JA. Lancaster MA, et al. Science. 2014 Jul 18;345(6194):1247125. doi: 10.1126/science.1247125. Epub 2014 Jul 17. Science. 2014. PMID: 25035496 Review.
Such stem cell-derived three-dimensional cultures are called organoids. Because organoids can be grown from human stem cells and from patient-derived induced pluripotent stem cells, they have the potential to model human development and disease. ...Here, we summariz …
Such stem cell-derived three-dimensional cultures are called organoids. Because organoids can be grown from human stem cells a …
Intestinal organoid cocultures with microbes.
Puschhof J, Pleguezuelos-Manzano C, Martinez-Silgado A, Akkerman N, Saftien A, Boot C, de Waal A, Beumer J, Dutta D, Heo I, Clevers H. Puschhof J, et al. Nat Protoc. 2021 Oct;16(10):4633-4649. doi: 10.1038/s41596-021-00589-z. Epub 2021 Aug 11. Nat Protoc. 2021. PMID: 34381208 Review.
This protocol comprises methods to coculture organoids with microbes, particularly focusing on human small intestinal and colon organoids exposed to individual bacterial species. Microinjection into the lumen and periphery of 3D organoids is discussed, …
This protocol comprises methods to coculture organoids with microbes, particularly focusing on human small intestinal and colo …
Tissue geometry drives deterministic organoid patterning.
Gjorevski N, Nikolaev M, Brown TE, Mitrofanova O, Brandenberg N, DelRio FW, Yavitt FM, Liberali P, Anseth KS, Lutolf MP. Gjorevski N, et al. Science. 2022 Jan 7;375(6576):eaaw9021. doi: 10.1126/science.aaw9021. Epub 2022 Jan 7. Science. 2022. PMID: 34990240 Free PMC article.
Bioengineered stem cell microenvironments are used to specify the initial geometry of intestinal organoids, which in turn controls their patterning and crypt formation. We leveraged the reproducibility and predictability of the culture to identify the underlying mec …
Bioengineered stem cell microenvironments are used to specify the initial geometry of intestinal organoids, which in turn cont …
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.
He GW, Lin L, DeMartino J, Zheng X, Staliarova N, Dayton T, Begthel H, van de Wetering WJ, Bodewes E, van Zon J, Tans S, Lopez-Iglesias C, Peters PJ, Wu W, Kotlarz D, Klein C, Margaritis T, Holstege F, Clevers H. He GW, et al. Cell Stem Cell. 2022 Sep 1;29(9):1333-1345.e6. doi: 10.1016/j.stem.2022.08.002. Epub 2022 Aug 23. Cell Stem Cell. 2022. PMID: 36002022 Free PMC article.
Opposing roles have been proposed for IL-22 in intestinal pathophysiology. We have optimized human small intestinal organoid (hSIO) culturing, constitutively generating all differentiated cell types while maintaining an active stem cell compartment. ...In hSI …
Opposing roles have been proposed for IL-22 in intestinal pathophysiology. We have optimized human small intestinal organoi …
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis.
Nikolaev M, Mitrofanova O, Broguiere N, Geraldo S, Dutta D, Tabata Y, Elci B, Brandenberg N, Kolotuev I, Gjorevski N, Clevers H, Lutolf MP. Nikolaev M, et al. Nature. 2020 Sep;585(7826):574-578. doi: 10.1038/s41586-020-2724-8. Epub 2020 Sep 16. Nature. 2020. PMID: 32939089
Epithelial organoids, such as those derived from stem cells of the intestine, have great potential for modelling tissue and disease biology(1-4). ...They retain key physiological hallmarks of the intestine and have a notable capacity to regenerate. Our concep …
Epithelial organoids, such as those derived from stem cells of the intestine, have great potential for modelling tissue and di …
Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration.
Qu M, Xiong L, Lyu Y, Zhang X, Shen J, Guan J, Chai P, Lin Z, Nie B, Li C, Xu J, Deng H. Qu M, et al. Cell Res. 2021 Mar;31(3):259-271. doi: 10.1038/s41422-020-00453-x. Epub 2021 Jan 8. Cell Res. 2021. PMID: 33420425 Free PMC article.
However, conventional organoid cultures primarily represent the homeostasis of self-organizing stem cells and their derivatives. Here, we established a novel intestinal organoid culture system composed of 8 components, mainly including VPA, EPZ6438, LDN193189 …
However, conventional organoid cultures primarily represent the homeostasis of self-organizing stem cells and their derivatives. Here …
Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells.
Pleguezuelos-Manzano C, Puschhof J, van den Brink S, Geurts V, Beumer J, Clevers H. Pleguezuelos-Manzano C, et al. Curr Protoc Immunol. 2020 Sep;130(1):e106. doi: 10.1002/cpim.106. Curr Protoc Immunol. 2020. PMID: 32940424 Free PMC article.
Intestinal organoids are useful tools for the study of intestinal physiology as well as many disease conditions. ...Additionally, this article provides an overview of several downstream applications of human intestinal organoids. 2020 The Author …
Intestinal organoids are useful tools for the study of intestinal physiology as well as many disease conditions. ...Add …
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ, Clevers H. Sato T, et al. Nature. 2009 May 14;459(7244):262-5. doi: 10.1038/nature07935. Epub 2009 Mar 29. Nature. 2009. PMID: 19329995
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. ...Single sorted Lgr5(+) stem cells can also initiate these cryptvillus organoids. Tracing experiments indicate that the Lgr5(+) stem-cell hierarchy is maintained in organoids …
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. ...Single sorted Lgr5(+) stem cells can also ini …
An organoid-based organ-repurposing approach to treat short bowel syndrome.
Sugimoto S, Kobayashi E, Fujii M, Ohta Y, Arai K, Matano M, Ishikawa K, Miyamoto K, Toshimitsu K, Takahashi S, Nanki K, Hakamata Y, Kanai T, Sato T. Sugimoto S, et al. Nature. 2021 Apr;592(7852):99-104. doi: 10.1038/s41586-021-03247-2. Epub 2021 Feb 24. Nature. 2021. PMID: 33627870
Organoid technology enables an efficient expansion of intestinal epithelium tissue in vitro(1), but reconstruction of the whole small intestine, including the complex lymphovascular system, has remained challenging(2). Here we generate a functional small i …
Organoid technology enables an efficient expansion of intestinal epithelium tissue in vitro(1), but reconstruction of the whol …
Phenotypic landscape of intestinal organoid regeneration.
Lukonin I, Serra D, Challet Meylan L, Volkmann K, Baaten J, Zhao R, Meeusen S, Colman K, Maurer F, Stadler MB, Jenkins J, Liberali P. Lukonin I, et al. Nature. 2020 Oct;586(7828):275-280. doi: 10.1038/s41586-020-2776-9. Epub 2020 Oct 7. Nature. 2020. PMID: 33029001 Free PMC article.
The development of intestinal organoids from single adult intestinal stem cells in vitro recapitulates the regenerative capacity of the intestinal epithelium(1,2). Here we unravel the mechanisms that orchestrate both organoid formation and the r …
The development of intestinal organoids from single adult intestinal stem cells in vitro recapitulates the regenerative …
3,294 results