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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 2
1966 6
1967 3
1968 5
1969 6
1970 7
1971 12
1972 11
1973 14
1974 10
1975 23
1976 15
1977 7
1978 11
1979 26
1980 20
1981 24
1982 15
1983 20
1984 11
1985 7
1986 7
1987 8
1988 6
1989 4
1990 1
1991 2
1992 1
1995 2
1996 1
1997 2
1998 1
1999 4
2000 2
2001 3
2003 2
2005 3
2006 1
2008 1
2009 1
2010 3
2011 7
2012 6
2013 4
2014 11
2015 23
2016 40
2017 39
2018 58
2019 81
2020 99
2021 143
2022 177
2023 152
2024 66

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1,123 results

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Page 1
A single-cell multiomic analysis of kidney organoid differentiation.
Yoshimura Y, Muto Y, Ledru N, Wu H, Omachi K, Miner JH, Humphreys BD. Yoshimura Y, et al. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2219699120. doi: 10.1073/pnas.2219699120. Epub 2023 May 8. Proc Natl Acad Sci U S A. 2023. PMID: 37155865 Free PMC article.
Kidney organoids differentiated from pluripotent stem cells are powerful models of kidney development and disease but are characterized by cell immaturity and off-target cell fates. ...Our approach provides an experimental framework to judge the cell-specific …
Kidney organoids differentiated from pluripotent stem cells are powerful models of kidney development and disease but a …
Kidney organoid research: current status and applications.
Trush O, Takasato M. Trush O, et al. Curr Opin Genet Dev. 2022 Aug;75:101944. doi: 10.1016/j.gde.2022.101944. Epub 2022 Jul 1. Curr Opin Genet Dev. 2022. PMID: 35785592 Review.
Human-induced pluripotent stem cells-derived kidney organoids became an indispensable tool to study human kidney development, model various diseases and infections leading to kidney damage, and offer a new route towards better drug development and vali …
Human-induced pluripotent stem cells-derived kidney organoids became an indispensable tool to study human kidney develo …
Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics.
Wu H, Uchimura K, Donnelly EL, Kirita Y, Morris SA, Humphreys BD. Wu H, et al. Cell Stem Cell. 2018 Dec 6;23(6):869-881.e8. doi: 10.1016/j.stem.2018.10.010. Epub 2018 Nov 15. Cell Stem Cell. 2018. PMID: 30449713 Free PMC article.
Kidney organoids derived from human pluripotent stem cells have great utility for investigating organogenesis and disease mechanisms and, potentially, as a replacement tissue source, but how closely organoids derived from current protocols replicate adult hum …
Kidney organoids derived from human pluripotent stem cells have great utility for investigating organogenesis and disease mech …
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery.
Tran T, Song CJ, Nguyen T, Cheng SY, McMahon JA, Yang R, Guo Q, Der B, Lindström NO, Lin DC, McMahon AP. Tran T, et al. Cell Stem Cell. 2022 Jul 7;29(7):1083-1101.e7. doi: 10.1016/j.stem.2022.06.005. Cell Stem Cell. 2022. PMID: 35803227 Free PMC article.
Human pluripotent stem-cell-derived organoids are models for human development and disease. We report a modified human kidney organoid system that generates thousands of similar organoids, each consisting of 1-2 nephron-like structures. ...To shed new …
Human pluripotent stem-cell-derived organoids are models for human development and disease. We report a modified human kidney …
Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation.
Lawlor KT, Vanslambrouck JM, Higgins JW, Chambon A, Bishard K, Arndt D, Er PX, Wilson SB, Howden SE, Tan KS, Li F, Hale LJ, Shepherd B, Pentoney S, Presnell SC, Chen AE, Little MH. Lawlor KT, et al. Nat Mater. 2021 Feb;20(2):260-271. doi: 10.1038/s41563-020-00853-9. Epub 2020 Nov 23. Nat Mater. 2021. PMID: 33230326 Free PMC article.
Directed differentiation of human pluripotent stem cells to kidney organoids brings the prospect of drug screening, disease modelling and the generation of tissue for renal replacement. ...This facilitates the manufacture of uniformly patterned kidney tissue …
Directed differentiation of human pluripotent stem cells to kidney organoids brings the prospect of drug screening, disease mo …
Navigating the kidney organoid: insights into assessment and enhancement of nephron function.
Tabibzadeh N, Satlin LM, Jain S, Morizane R. Tabibzadeh N, et al. Am J Physiol Renal Physiol. 2023 Dec 1;325(6):F695-F706. doi: 10.1152/ajprenal.00166.2023. Epub 2023 Sep 28. Am J Physiol Renal Physiol. 2023. PMID: 37767571 Review.
Kidney organoids produced using several protocols harbor key structures of native kidneys. Here, we review the current state, recent advances, and future challenges in the functional characterization of kidney organoids, strategies to accelerate …
Kidney organoids produced using several protocols harbor key structures of native kidneys. Here, we review the current …
Kidney and organoid single-cell transcriptomics: the end of the beginning.
Wilson PC, Humphreys BD. Wilson PC, et al. Pediatr Nephrol. 2020 Feb;35(2):191-197. doi: 10.1007/s00467-018-4177-y. Epub 2019 Jan 4. Pediatr Nephrol. 2020. PMID: 30607565 Free PMC article. Review.
Single-cell RNA sequencing (scRNA-seq) technologies are increasingly being applied to reveal cellular heterogeneity in kidney development and disease. In just the last year, multiple scRNA-seq datasets have been generated from kidney organoids, developing mou …
Single-cell RNA sequencing (scRNA-seq) technologies are increasingly being applied to reveal cellular heterogeneity in kidney develop …
An integrated organoid omics map extends modeling potential of kidney disease.
Lassé M, El Saghir J, Berthier CC, Eddy S, Fischer M, Laufer SD, Kylies D, Hutzfeldt A, Bonin LL, Dumoulin B, Menon R, Vega-Warner V, Eichinger F, Alakwaa F, Fermin D, Billing AM, Minakawa A, McCown PJ, Rose MP, Godfrey B, Meister E, Wiech T, Noriega M, Chrysopoulou M, Brandts P, Ju W, Reinhard L, Hoxha E, Grahammer F, Lindenmeyer MT, Huber TB, Schlüter H, Thiel S, Mariani LH, Puelles VG, Braun F, Kretzler M, Demir F, Harder JL, Rinschen MM. Lassé M, et al. Nat Commun. 2023 Aug 14;14(1):4903. doi: 10.1038/s41467-023-39740-7. Nat Commun. 2023. PMID: 37580326 Free PMC article.
Kidney organoids are a promising model to study kidney disease, but their use is constrained by limited knowledge of their functional protein expression profile. ...By integrating kidney organoid omic layers, incorporating a disease-relevant cyt …
Kidney organoids are a promising model to study kidney disease, but their use is constrained by limited knowledge of th …
Single-cell RNA sequencing and kidney organoid differentiation.
Uchimura K. Uchimura K. Clin Exp Nephrol. 2023 Jul;27(7):585-592. doi: 10.1007/s10157-023-02359-5. Epub 2023 May 20. Clin Exp Nephrol. 2023. PMID: 37209321 Free PMC article. Review.
We have performed a comprehensive analysis using scRNA-seq to define how kidney organoids can be applied to understand kidney development and pathology. The structure of kidney organoids is complex and contains many cell types of varying maturit …
We have performed a comprehensive analysis using scRNA-seq to define how kidney organoids can be applied to understand kidn …
Immune-infiltrated kidney organoid-on-chip model for assessing T cell bispecific antibodies.
Kroll KT, Mata MM, Homan KA, Micallef V, Carpy A, Hiratsuka K, Morizane R, Moisan A, Gubler M, Walz AC, Marrer-Berger E, Lewis JA. Kroll KT, et al. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2305322120. doi: 10.1073/pnas.2305322120. Epub 2023 Aug 21. Proc Natl Acad Sci U S A. 2023. PMID: 37603766 Free PMC article.
Unfortunately, traditional models for assessing their effects on human tissues often lack predictive capability, particularly for "on-target, off-tumor" interactions. Here, we report an immune-infiltrated, kidney organoid-on-chip model in which peripheral blood mono …
Unfortunately, traditional models for assessing their effects on human tissues often lack predictive capability, particularly for "on-target …
1,123 results