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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 2
1968 3
1969 4
1970 3
1971 9
1972 2
1973 7
1974 4
1975 2
1976 7
1977 5
1978 2
1979 5
1980 12
1981 10
1982 7
1983 3
1984 8
1985 3
1986 4
1987 11
1988 8
1992 2
1993 1
1994 2
1995 1
1996 2
1998 1
2001 2
2002 1
2004 1
2006 1
2007 1
2008 2
2009 2
2010 1
2011 2
2012 1
2013 5
2014 9
2015 14
2016 20
2017 19
2018 30
2019 54
2020 70
2021 77
2022 66
2023 64
2024 32

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547 results

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Page 1
Patient-derived organoids of pancreatic ductal adenocarcinoma for subtype determination and clinical outcome prediction.
Matsumoto K, Fujimori N, Ichihara K, Takeno A, Murakami M, Ohno A, Kakehashi S, Teramatsu K, Ueda K, Nakata K, Sugahara O, Yamamoto T, Matsumoto A, Nakayama KI, Oda Y, Nakamura M, Ogawa Y. Matsumoto K, et al. J Gastroenterol. 2024 Apr 29. doi: 10.1007/s00535-024-02103-0. Online ahead of print. J Gastroenterol. 2024. PMID: 38684511
However, the "molecular" classification has not been applied in real-world clinical practice. This study aimed to establish patient-derived organoids (PDOs) for PDAC and evaluate their application in subtype classification and clinical outcome prediction. ...
However, the "molecular" classification has not been applied in real-world clinical practice. This study aimed to establish patient-derived …
FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection.
Meng H, Liao Z, Ji Y, Wang D, Han Y, Huang C, Hu X, Chen J, Zhang H, Li Z, Wang C, Sun H, Sun J, Chen L, Yin J, Zhao J, Xu T, Liu H. Meng H, et al. Signal Transduct Target Ther. 2024 Apr 23;9(1):104. doi: 10.1038/s41392-024-01790-8. Signal Transduct Target Ther. 2024. PMID: 38654010 Free PMC article.
The angiotensin-converting enzyme 2 (ACE2) is a primary cell surface viral binding receptor for SARS-CoV-2, so finding new regulatory molecules to modulate ACE2 expression levels is a promising strategy against COVID-19. In the current study, we utilized islet organoids de …
The angiotensin-converting enzyme 2 (ACE2) is a primary cell surface viral binding receptor for SARS-CoV-2, so finding new regulatory molecu …
Traditional and emerging strategies using hepatocytes for pancreatic regenerative medicine.
Liu S, Zhang Y, Luo Y, Liu J. Liu S, et al. J Diabetes. 2024 Apr;16(4):e13545. doi: 10.1111/1753-0407.13545. J Diabetes. 2024. PMID: 38599852 Free PMC article. Review.
Although pancreas and islet cell transplantation are the only ways to prevent the late complications of insulin-dependent diabetes, a shortage of donors is a major obstacle to tissue and organ transplantation. ...In addition, clustered regularly interspaced short palindrom …
Although pancreas and islet cell transplantation are the only ways to prevent the late complications of insulin-dependent diabetes, a …
The porcine islet-derived organoid showed the characteristics as pancreatic duct.
Sakata N, Yoshimatsu G, Kawakami R, Nakano K, Yamada T, Yamamura A, Nagashima H, Kodama S. Sakata N, et al. Sci Rep. 2024 Mar 16;14(1):6401. doi: 10.1038/s41598-024-57059-1. Sci Rep. 2024. PMID: 38493252 Free PMC article.
Organoid is a tissue-engineered organ-like structure that resemble as an organ. ...These findings were seen in long-term-cultured porcine islets. In conclusion, our porcine islet organoids showed the characteristics of pancreatic ducts. Further study is necessary fo …
Organoid is a tissue-engineered organ-like structure that resemble as an organ. ...These findings were seen in long-term-cultured por …
Comparison of endoscopic ultrasound-guided fine-needle aspiration and fine-needle biopsy to generate pancreatic cancer organoids: Randomized trial.
Wiessner JR, Orben F, Schäfer A, Fricke L, Schneider G, Reichert M, Herner A, Mayr U, Phillip V, Treiber M, von Figura G, Abdelhafez M, Schmid RM, Schlag C. Wiessner JR, et al. Endosc Int Open. 2024 Mar 7;12(3):E361-E366. doi: 10.1055/a-2257-3171. eCollection 2024 Mar. Endosc Int Open. 2024. PMID: 38464982 Free PMC article.
Molecular diagnostics and customized therapies are becoming increasingly important in clinical routine. Patient-derived, predictive model systems such as organoids have the potential to substantially increase the depth of information from biopsy material by functional and …
Molecular diagnostics and customized therapies are becoming increasingly important in clinical routine. Patient-derived, predictive model sy …
A single-cell atlas of the murine pancreatic ductal tree identifies novel cell populations with potential implications in pancreas regeneration and exocrine pathogenesis.
Fernández Á, Casamitjana J, Holguín-Horcajo A, Coolens K, Mularoni L, Pasquali L, Bailey-Lundberg JM, Rooman I, Wang YJ, Rovira M. Fernández Á, et al. bioRxiv [Preprint]. 2024 Feb 29:2024.02.26.582044. doi: 10.1101/2024.02.26.582044. bioRxiv. 2024. PMID: 38463969 Free PMC article. Preprint.
METHODS: We used scRNA-seq to comprehensively characterize mouse ductal heterogeneity at single-cell resolution of the entire ductal epithelium from centroacinar cells to the main duct. Moreover, we used organoid cultures, injury models and pancreatic tumor samples to inte …
METHODS: We used scRNA-seq to comprehensively characterize mouse ductal heterogeneity at single-cell resolution of the entire ductal epithel …
Revolutionizing pancreatic islet organoid transplants: Improving engraftment and exploring future frontiers.
Abraham N, Kolipaka T, Pandey G, Negi M, Srinivasarao DA, Srivastava S. Abraham N, et al. Life Sci. 2024 Apr 15;343:122545. doi: 10.1016/j.lfs.2024.122545. Epub 2024 Mar 6. Life Sci. 2024. PMID: 38458556 Review.
Hence this article focuses on strategies enhancing the in vivo engraftment of islet organoids (IOs), namely vascularization, encapsulation, immune evasion, alternative extra-hepatic transplant sites and 3D bioprinting. Hypoxia-induced necrosis and delayed revascularization …
Hence this article focuses on strategies enhancing the in vivo engraftment of islet organoids (IOs), namely vascularization, encapsul …
Deficiency in SLC25A15, a hypoxia-responsive gene, promotes hepatocellular carcinoma by reprogramming glutamine metabolism.
Zhang Q, Wei T, Jin W, Yan L, Shi L, Zhu S, Bai Y, Zeng Y, Yin Z, Yang J, Zhang W, Wu M, Zhang Y, Peng G, Roessler S, Liu L. Zhang Q, et al. J Hepatol. 2024 Feb;80(2):293-308. doi: 10.1016/j.jhep.2023.10.024. Epub 2023 Oct 30. J Hepatol. 2024. PMID: 38450598
METHODS: We systematically investigated the function of SLC25A15 in HCC progression using large-scale data mining and cell, animal, and organoid models. Furthermore, we analyzed its involvement in reprogramming glutamine metabolism. ...
METHODS: We systematically investigated the function of SLC25A15 in HCC progression using large-scale data mining and cell, animal, and o …
SOX2 and OCT4 mediate radiation and drug resistance in pancreatic tumor organoids.
Roy S, Dukic T, Keepers Z, Bhandary B, Lamichhane N, Molitoris J, Ko YH, Banerjee A, Shukla HD. Roy S, et al. Cell Death Discov. 2024 Mar 1;10(1):106. doi: 10.1038/s41420-024-01871-1. Cell Death Discov. 2024. PMID: 38429272 Free PMC article.
In this study, we evaluated the role of pancreatic cancer stem cells (CSC) using OCT4 and SOX2, CSC markers in mouse pancreatic tumor organoids. We treated pancreatic tumor organoids with 4 or 8 Gy of radiation, 10 muM of 5-FU (5-Fluorouracil), and 100 muM 3-Bromopy …
In this study, we evaluated the role of pancreatic cancer stem cells (CSC) using OCT4 and SOX2, CSC markers in mouse pancreatic tumor org …
547 results