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Year Number of Results
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1981 3
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2001 3
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2005 1
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388 results

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Page 1
Organoid culture systems for prostate epithelial and cancer tissue.
Drost J, Karthaus WR, Gao D, Driehuis E, Sawyers CL, Chen Y, Clevers H. Drost J, et al. Nat Protoc. 2016 Feb;11(2):347-58. doi: 10.1038/nprot.2016.006. Epub 2016 Jan 21. Nat Protoc. 2016. PMID: 26797458 Free PMC article.
This protocol describes a strategy for the generation of 3D prostate organoid cultures from healthy mouse and human prostate cells (either bulk or FACS-sorted single luminal and basal cells), metastatic prostate cancer lesions and circulating tumor cel …
This protocol describes a strategy for the generation of 3D prostate organoid cultures from healthy mouse and human prostat …
Organoid cultures derived from patients with advanced prostate cancer.
Gao D, Vela I, Sboner A, Iaquinta PJ, Karthaus WR, Gopalan A, Dowling C, Wanjala JN, Undvall EA, Arora VK, Wongvipat J, Kossai M, Ramazanoglu S, Barboza LP, Di W, Cao Z, Zhang QF, Sirota I, Ran L, MacDonald TY, Beltran H, Mosquera JM, Touijer KA, Scardino PT, Laudone VP, Curtis KR, Rathkopf DE, Morris MJ, Danila DC, Slovin SF, Solomon SB, Eastham JA, Chi P, Carver B, Rubin MA, Scher HI, Clevers H, Sawyers CL, Chen Y. Gao D, et al. Cell. 2014 Sep 25;159(1):176-187. doi: 10.1016/j.cell.2014.08.016. Epub 2014 Sep 4. Cell. 2014. PMID: 25201530 Free PMC article.
Using a 3D organoid system, we report success in long-term culture of prostate cancer from biopsy specimens and circulating tumor cells. The first seven fully characterized organoid lines recapitulate the molecular diversity of prostate cancer subtypes …
Using a 3D organoid system, we report success in long-term culture of prostate cancer from biopsy specimens and circulating tu …
Identification of multipotent luminal progenitor cells in human prostate organoid cultures.
Karthaus WR, Iaquinta PJ, Drost J, Gracanin A, van Boxtel R, Wongvipat J, Dowling CM, Gao D, Begthel H, Sachs N, Vries RGJ, Cuppen E, Chen Y, Sawyers CL, Clevers HC. Karthaus WR, et al. Cell. 2014 Sep 25;159(1):163-175. doi: 10.1016/j.cell.2014.08.017. Epub 2014 Sep 4. Cell. 2014. PMID: 25201529 Free PMC article.
Organoids are genetically stable, reconstitute prostate glands in recombination assays, and can be experimentally manipulated. Single human luminal and basal cells give rise to organoids, yet luminal-cell-derived organoids more closely resemble pros …
Organoids are genetically stable, reconstitute prostate glands in recombination assays, and can be experimentally manipulated. …
Application of Organoid Models in Prostate Cancer Research.
Zhou L, Zhang C, Zhang Y, Shi C. Zhou L, et al. Front Oncol. 2021 Sep 27;11:736431. doi: 10.3389/fonc.2021.736431. eCollection 2021. Front Oncol. 2021. PMID: 34646778 Free PMC article. Review.
Additionally, we look forward to other potential developmental directions of PCa organoids, such as the interaction between prostate cancer tumor cells and their microenvironment, clinical individualized treatments, heterogeneous transformation model, tumor immunoth …
Additionally, we look forward to other potential developmental directions of PCa organoids, such as the interaction between prosta …
A synopsis of prostate organoid methodologies, applications, and limitations.
Gleave AM, Ci X, Lin D, Wang Y. Gleave AM, et al. Prostate. 2020 May;80(6):518-526. doi: 10.1002/pros.23966. Epub 2020 Feb 21. Prostate. 2020. PMID: 32084293 Review.
METHODS: To make better use of organoid models in the PCa research field, we provide a review of cutting-edge prostate organoid methodologies, applications, and limitations. ...We highlight the patient-derived xenograft (PDX)-organoid interface model, …
METHODS: To make better use of organoid models in the PCa research field, we provide a review of cutting-edge prostate orga …
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling.
Chan JM, Zaidi S, Love JR, Zhao JL, Setty M, Wadosky KM, Gopalan A, Choo ZN, Persad S, Choi J, LaClair J, Lawrence KE, Chaudhary O, Xu T, Masilionis I, Linkov I, Wang S, Lee C, Barlas A, Morris MJ, Mazutis L, Chaligne R, Chen Y, Goodrich DW, Karthaus WR, Pe'er D, Sawyers CL. Chan JM, et al. Science. 2022 Sep 9;377(6611):1180-1191. doi: 10.1126/science.abn0478. Epub 2022 Aug 18. Science. 2022. PMID: 35981096 Free PMC article.
Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered mouse models, we investigated the causes of lineage plasticity in p …
Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity re …
Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states.
Song H, Weinstein HNW, Allegakoen P, Wadsworth MH 2nd, Xie J, Yang H, Castro EA, Lu KL, Stohr BA, Feng FY, Carroll PR, Wang B, Cooperberg MR, Shalek AK, Huang FW. Song H, et al. Nat Commun. 2022 Jan 10;13(1):141. doi: 10.1038/s41467-021-27322-4. Nat Commun. 2022. PMID: 35013146 Free PMC article.
To characterize the prostate cancer tumor microenvironment, we perform single-cell RNA-sequencing on prostate biopsies, prostatectomy specimens, and patient-derived organoids from localized prostate cancer patients. We uncover heterogeneous cellular st …
To characterize the prostate cancer tumor microenvironment, we perform single-cell RNA-sequencing on prostate biopsies, prosta …
Prostate organoid technology - the new POT of gold in prostate stem cell and cancer research.
Mai CW, Shu Y, Cheong SK, Chua CW. Mai CW, et al. Sheng Li Xue Bao. 2021 Apr 25;73(2):181-196. Sheng Li Xue Bao. 2021. PMID: 33903880 Free article. Review.
In the recent years, organoids technology has contributed to the revolutionary changes in stem cell and cancer fields. In this review, we have briefly overviewed the emerging landscape of prostate organoid technology (POT) in prostate research. In addi …
In the recent years, organoids technology has contributed to the revolutionary changes in stem cell and cancer fields. In this review …
Regenerative potential of prostate luminal cells revealed by single-cell analysis.
Karthaus WR, Hofree M, Choi D, Linton EL, Turkekul M, Bejnood A, Carver B, Gopalan A, Abida W, Laudone V, Biton M, Chaudhary O, Xu T, Masilionis I, Manova K, Mazutis L, Pe'er D, Regev A, Sawyers CL. Karthaus WR, et al. Science. 2020 May 1;368(6490):497-505. doi: 10.1126/science.aay0267. Science. 2020. PMID: 32355025 Free PMC article.
The prostate regenerates when androgen is restored, a process postulated to involve stem cells. ...In organoids and in mice, both populations contribute equally to prostate regeneration, partly through androgen-driven expression of growth factors (Nrg2, Rspo3 …
The prostate regenerates when androgen is restored, a process postulated to involve stem cells. ...In organoids and in mice, b …
Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets.
Tang F, Xu D, Wang S, Wong CK, Martinez-Fundichely A, Lee CJ, Cohen S, Park J, Hill CE, Eng K, Bareja R, Han T, Liu EM, Palladino A, Di W, Gao D, Abida W, Beg S, Puca L, Meneses M, de Stanchina E, Berger MF, Gopalan A, Dow LE, Mosquera JM, Beltran H, Sternberg CN, Chi P, Scher HI, Sboner A, Chen Y, Khurana E. Tang F, et al. Science. 2022 May 27;376(6596):eabe1505. doi: 10.1126/science.abe1505. Epub 2022 May 27. Science. 2022. PMID: 35617398 Free PMC article.
In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR) dependence leads to clinically aggressive tumors with few therapeutic options. We used ATAC-seq (assay for transposase-accessible chromatin sequencing), RNA-seq, and DNA sequencing to invest …
In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR) dependence leads to clinically aggressive tumors w …
388 results