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Page 1
Original antigenic sin: A comprehensive review.
Vatti A, Monsalve DM, Pacheco Y, Chang C, Anaya JM, Gershwin ME. Vatti A, et al. J Autoimmun. 2017 Sep;83:12-21. doi: 10.1016/j.jaut.2017.04.008. Epub 2017 May 5. J Autoimmun. 2017. PMID: 28479213 Review.
The concept of "original antigenic sin" was first proposed by Thomas Francis, Jr. in 1960. ...The basis of "original antigenic sin" requires immunological memory, and our immune system ability to autocorrect. ...
The concept of "original antigenic sin" was first proposed by Thomas Francis, Jr. in 1960. ...The basis of "original …
Original Antigenic Sin: How Original? How Sinful?
Yewdell JW, Santos JJS. Yewdell JW, et al. Cold Spring Harb Perspect Med. 2021 May 3;11(5):a038786. doi: 10.1101/cshperspect.a038786. Cold Spring Harb Perspect Med. 2021. PMID: 31964645 Free PMC article. Review.
We review the phenomenon of "original antigenic sin" (OAS) in antibody responses to influenza A virus (IAV) infection or vaccination. ...
We review the phenomenon of "original antigenic sin" (OAS) in antibody responses to influenza A virus (IAV) infection o …
The "original antigenic sin" and its relevance for SARS-CoV-2 (COVID-19) vaccination.
Rijkers GT, van Overveld FJ. Rijkers GT, et al. Clin Immunol Commun. 2021 Dec;1:13-16. doi: 10.1016/j.clicom.2021.10.001. Epub 2021 Oct 8. Clin Immunol Commun. 2021. PMID: 38620690 Free PMC article. Review.
The preferential expansion of cross-reactive antibodies, or T-lymphocytes for that matter, by a related antigen has been termed the original antigenic sin and was first described by Thomas Francis Jr. in 1960. ...The antibody dependent enhancement obse …
The preferential expansion of cross-reactive antibodies, or T-lymphocytes for that matter, by a related antigen has been termed the …
Impact of antigenic evolution and original antigenic sin on SARS-CoV-2 immunity.
Aguilar-Bretones M, Fouchier RA, Koopmans MP, van Nierop GP. Aguilar-Bretones M, et al. J Clin Invest. 2023 Jan 3;133(1):e162192. doi: 10.1172/JCI162192. J Clin Invest. 2023. PMID: 36594464 Free PMC article. Review.
For influenza, efficacy of repeated vaccination is hampered by original antigenic sin, an attribute of immune memory that leads to greater induction of antibodies specific to the first-encountered variant of an immunogen compared with subsequent variants. In …
For influenza, efficacy of repeated vaccination is hampered by original antigenic sin, an attribute of immune memory th …
Original Antigenic Sin: How First Exposure Shapes Lifelong Anti-Influenza Virus Immune Responses.
Zhang A, Stacey HD, Mullarkey CE, Miller MS. Zhang A, et al. J Immunol. 2019 Jan 15;202(2):335-340. doi: 10.4049/jimmunol.1801149. J Immunol. 2019. PMID: 30617114 Review.
The term "original antigenic sin" (OAS) was first used in the 1960s to describe how one's first exposure to influenza virus shapes the outcome of subsequent exposures to antigenically related strains. ...
The term "original antigenic sin" (OAS) was first used in the 1960s to describe how one's first exposure to influenza v …
Original Antigenic Sin Response to RNA Viruses and Antiviral Immunity.
Park MS, Kim JI, Park S, Lee I, Park MS. Park MS, et al. Immune Netw. 2016 Oct;16(5):261-270. doi: 10.4110/in.2016.16.5.261. Epub 2016 Oct 25. Immune Netw. 2016. PMID: 27799871 Free PMC article. Review.
This has been termed 'original antigenic sin'. This adverse immunological effect can alter vaccine effectiveness and sometimes cause enhanced pathogenicity or additional inflammatory responses, according to the type of pathogen and the circumstances of infect …
This has been termed 'original antigenic sin'. This adverse immunological effect can alter vaccine effectiveness and so …
From Original Antigenic Sin to the Universal Influenza Virus Vaccine.
Henry C, Palm AE, Krammer F, Wilson PC. Henry C, et al. Trends Immunol. 2018 Jan;39(1):70-79. doi: 10.1016/j.it.2017.08.003. Epub 2017 Aug 31. Trends Immunol. 2018. PMID: 28867526 Free PMC article. Review.
Humans are exposed to a multitude of influenza viruses throughout their lifetime and it is clear that immune history influences the magnitude and quality of the antibody response. The 'original antigenic sin' concept refers to the impact of the first influenz …
Humans are exposed to a multitude of influenza viruses throughout their lifetime and it is clear that immune history influences the magnitud …
The Doctrine of Original Antigenic Sin: Separating Good From Evil.
Monto AS, Malosh RE, Petrie JG, Martin ET. Monto AS, et al. J Infect Dis. 2017 Jun 15;215(12):1782-1788. doi: 10.1093/infdis/jix173. J Infect Dis. 2017. PMID: 28398521 Free PMC article. Review.
The term "original antigenic sin" was coined approximately 60 years ago to describe the imprinting by the initial first influenza A virus infection on the antibody response to subsequent vaccination. ...It is essential that we understand better the immunologi …
The term "original antigenic sin" was coined approximately 60 years ago to describe the imprinting by the initial first …
Thyroid Autoantibodies Display both "Original Antigenic Sin" and Epitope Spreading.
McLachlan SM, Rapoport B. McLachlan SM, et al. Front Immunol. 2017 Dec 20;8:1845. doi: 10.3389/fimmu.2017.01845. eCollection 2017. Front Immunol. 2017. PMID: 29326719 Free PMC article. Review.
Evidence for original antigenic sin in spontaneous thyroid autoimmunity is revealed by autoantibody interactions with immunodominant regions on thyroid autoantigens, thyroglobulin (Tg), thyroid peroxidase (TPO), and the thyrotropin receptor (TSHR) A-subunit. …
Evidence for original antigenic sin in spontaneous thyroid autoimmunity is revealed by autoantibody interactions with i …
Original antigenic sin: not so sinful after all.
Baumgarth N. Baumgarth N. Trends Immunol. 2023 Jul;44(7):487-489. doi: 10.1016/j.it.2023.05.010. Epub 2023 Jun 8. Trends Immunol. 2023. PMID: 37296058
'Original antigenic sin' predicts that antibody responses to secondary infections with escape mutants are dominated by specificities to the original pathogen. ...
'Original antigenic sin' predicts that antibody responses to secondary infections with escape mutants are dominated by …
266 results

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