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Oxidative Modification of miR-184 Enables It to Target Bcl-xL and Bcl-w.
Wang JX, Gao J, Ding SL, Wang K, Jiao JQ, Wang Y, Sun T, Zhou LY, Long B, Zhang XJ, Li Q, Liu JP, Feng C, Liu J, Gong Y, Zhou Z, Li PF. Wang JX, et al. Mol Cell. 2015 Jul 2;59(1):50-61. doi: 10.1016/j.molcel.2015.05.003. Epub 2015 May 28. Mol Cell. 2015. PMID: 26028536 Free article.
Here we report that miRNAs can be oxidatively modified by ROS. We identified that miR-184 upon oxidative modification associates with the 3' UTRs of Bcl-xL and Bcl-w that are not its native targets. The mismatch of oxidized miR- …
Here we report that miRNAs can be oxidatively modified by ROS. We identified that miR-184 upon oxidative modi …
LncRNA UCA1 attenuates autophagy-dependent cell death through blocking autophagic flux under arsenic stress.
Gao M, Li C, Xu M, Liu Y, Liu S. Gao M, et al. Toxicol Lett. 2018 Mar 1;284:195-204. doi: 10.1016/j.toxlet.2017.12.009. Epub 2017 Dec 15. Toxicol Lett. 2018. PMID: 29248574
Meanwhile, epigenetic regulations (such as miRNAs and histone modifications) were also reported to contribute to As-induced adverse effects. ...Functional assessments revealed that UCA1 played a critical role in protecting hepatocytes from As-induced autophagy inhibition. …
Meanwhile, epigenetic regulations (such as miRNAs and histone modifications) were also reported to contribute to As-induced adverse e …