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Impact of Altered Intestinal Microbiota on Chronic Kidney Disease Progression.
Castillo-Rodriguez E, Fernandez-Prado R, Esteras R, Perez-Gomez MV, Gracia-Iguacel C, Fernandez-Fernandez B, Kanbay M, Tejedor A, Lazaro A, Ruiz-Ortega M, Gonzalez-Parra E, Sanz AB, Ortiz A, Sanchez-Niño MD. Castillo-Rodriguez E, et al. Toxins (Basel). 2018 Jul 19;10(7):300. doi: 10.3390/toxins10070300. Toxins (Basel). 2018. PMID: 30029499 Free PMC article. Review.
Some uremic toxins result from nutrient processing by gut microbiota, yielding precursors of uremic toxins or uremic toxins themselves, such as trimethylamine N-Oxide (TMAO), p-cresyl sulphate, indoxyl sulphate and indole-3 acetic acid. Increased intake of some nutr …
Some uremic toxins result from nutrient processing by gut microbiota, yielding precursors of uremic toxins or uremic toxins themselves, such …
Chronic Kidney Disease, Gut Dysbiosis, and Constipation: A Burdensome Triplet.
Ikee R, Sasaki N, Yasuda T, Fukazawa S. Ikee R, et al. Microorganisms. 2020 Nov 25;8(12):1862. doi: 10.3390/microorganisms8121862. Microorganisms. 2020. PMID: 33255763 Free PMC article. Review.
CKD-related gut dysbiosis is considered to be characterized by the expansion of bacterial species producing precursors of harmful uremic toxins, such as indoxyl sulfate and p-cresyl sulfate, and the contraction of species generating beneficial short-chain fatty acid …
CKD-related gut dysbiosis is considered to be characterized by the expansion of bacterial species producing precursors of harmful uremic tox …
Nutritional Therapy Modulates Intestinal Microbiota and Reduces Serum Levels of Total and Free Indoxyl Sulfate and P-Cresyl Sulfate in Chronic Kidney Disease (Medika Study).
Di Iorio BR, Rocchetti MT, De Angelis M, Cosola C, Marzocco S, Di Micco L, di Bari I, Accetturo M, Vacca M, Gobbetti M, Di Iorio M, Bellasi A, Gesualdo L. Di Iorio BR, et al. J Clin Med. 2019 Sep 10;8(9):1424. doi: 10.3390/jcm8091424. J Clin Med. 2019. PMID: 31510015 Free PMC article.
In chronic kidney disease (CKD), the gut-microbiota metabolites indoxyl sulfate (IS) and p-cresyl sulfate (PCS) progressively accumulate due to their high albumin-binding capacity, leading to clinical complications. ...The increased level of potential anti-inflammat …
In chronic kidney disease (CKD), the gut-microbiota metabolites indoxyl sulfate (IS) and p-cresyl sulfate (PCS) progressively …
Gut Microbiota and Their Derived Metabolites, a Search for Potential Targets to Limit Accumulation of Protein-Bound Uremic Toxins in Chronic Kidney Disease.
Steenbeke M, Valkenburg S, Gryp T, Van Biesen W, Delanghe JR, Speeckaert MM, Glorieux G. Steenbeke M, et al. Toxins (Basel). 2021 Nov 17;13(11):809. doi: 10.3390/toxins13110809. Toxins (Basel). 2021. PMID: 34822593 Free PMC article.
The relationship between fecal metabolites and plasma concentrations of PBUTs in different stages of CKD (n = 103) was explored. Estimated GFR tends to correlate with fecal butyric acid (BA) concentrations (r(s) = 0.212; p = 0.032), which, in its turn, correlates with the …
The relationship between fecal metabolites and plasma concentrations of PBUTs in different stages of CKD (n = 103) was explored. Estimated G …
Gut Microbiome Profiling Uncovers a Lower Abundance of Butyricicoccus in Advanced Stages of Chronic Kidney Disease.
Gryp T, Faust K, Van Biesen W, Huys GRB, Verbeke F, Speeckaert M, Raes J, Vaneechoutte M, Joossens M, Glorieux G. Gryp T, et al. J Pers Med. 2021 Oct 29;11(11):1118. doi: 10.3390/jpm11111118. J Pers Med. 2021. PMID: 34834470 Free PMC article.
Although a substantial inter-individual difference in abundance of the top 15 genera was observed, no significant difference was observed between groups. Bristol stool scale (BSS) correlated negatively with p-cresyl sulfate and hippuric acid levels, irrespective of …
Although a substantial inter-individual difference in abundance of the top 15 genera was observed, no significant difference was observed be …
Gut Microbiota Mediates the Protective Effects of Traditional Chinese Medicine Formula Qiong-Yu-Gao against Cisplatin-Induced Acute Kidney Injury.
Zou YT, Zhou J, Zhu JH, Wu CY, Shen H, Zhang W, Zhou SS, Xu JD, Mao Q, Zhang YQ, Long F, Li SL. Zou YT, et al. Microbiol Spectr. 2022 Jun 29;10(3):e0075922. doi: 10.1128/spectrum.00759-22. Epub 2022 Apr 28. Microbiol Spectr. 2022. PMID: 35481834 Free PMC article.
We found that QYG treatment significantly attenuated cisplatin-induced AKI and gut dysbiosis, altered the levels of bacterial metabolites, with short-chain fatty acids (SCFAs) such as acetic acid and butyric acid increasing and uremic toxins such as indoxyl sulfate and …
We found that QYG treatment significantly attenuated cisplatin-induced AKI and gut dysbiosis, altered the levels of bacterial metabolites, w …
Effect of Dietary Inulin Supplementation on the Gut Microbiota Composition and Derived Metabolites of Individuals Undergoing Hemodialysis: A Pilot Study.
Biruete A, Cross TL, Allen JM, Kistler BM, de Loor H, Evenepoel P, Fahey GC Jr, Bauer L, Swanson KS, Wilund KR. Biruete A, et al. J Ren Nutr. 2021 Sep;31(5):512-522. doi: 10.1053/j.jrn.2020.10.003. Epub 2021 Jun 11. J Ren Nutr. 2021. PMID: 34120835 Free PMC article. Clinical Trial.
We assessed the fecal microbiota composition, fecal metabolites (short-chain fatty acids (SCFA), phenols, and indoles), and plasma indoxyl sulfate and p-cresyl sulfate. RESULTS: At baseline, factors that explained the gut microbiota variability included BMI category …
We assessed the fecal microbiota composition, fecal metabolites (short-chain fatty acids (SCFA), phenols, and indoles), and plasma indoxyl s …
Compositional and Functional Adaptations of Intestinal Microbiota and Related Metabolites in CKD Patients Receiving Dietary Protein Restriction.
Wu IW, Lee CC, Hsu HJ, Sun CY, Chen YC, Yang KJ, Yang CW, Chung WH, Lai HC, Chang LC, Su SC. Wu IW, et al. Nutrients. 2020 Sep 12;12(9):2799. doi: 10.3390/nu12092799. Nutrients. 2020. PMID: 32932711 Free PMC article. Clinical Trial.
CKD-LPD had a significant decrease in the abundance of many butyrate-producing bacteria (family Lachnospiraceae and Bacteroidaceae) associated with enrichment of functional module of butanoate metabolism, leading to concomitant reduction in serum levels of SCFA (acetic, he …
CKD-LPD had a significant decrease in the abundance of many butyrate-producing bacteria (family Lachnospiraceae and Bacteroidaceae) a …
Lactobacillus acidophilus KBL409 protects against kidney injury via improving mitochondrial function with chronic kidney disease.
Park J, Nam KH, Nam BY, Kim G, Kim H, Lee KU, Song SC, Nam TW, Kim WK, Park JT, Yoo TH, Kang SW, Ko G, Han SH. Park J, et al. Eur J Nutr. 2024 May 6. doi: 10.1007/s00394-024-03408-9. Online ahead of print. Eur J Nutr. 2024. PMID: 38705901
To clarify the underlying mechanisms by which probiotics exert protective effects on mitochondria in CKD, primary mouse tubular epithelial cells stimulated with TGF-beta and p-cresyl sulfate were administered with butyrate. RESULTS: In CKD mice, PGC-1alpha an …
To clarify the underlying mechanisms by which probiotics exert protective effects on mitochondria in CKD, primary mouse tubular epithelial c …