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Year Number of Results
1970 1
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1980 1
1981 4
1982 12
1983 26
1984 46
1985 46
1986 61
1987 49
1988 85
1989 100
1990 162
1991 316
1992 650
1993 993
1994 1568
1995 1940
1996 2273
1997 2683
1998 2962
1999 3209
2000 3459
2001 3451
2002 3523
2003 3518
2004 3611
2005 3696
2006 3929
2007 3994
2008 4166
2009 4353
2010 4676
2011 5060
2012 5155
2013 5398
2014 5503
2015 5533
2016 5377
2017 5448
2018 5411
2019 5486
2020 5952
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2022 5340
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120,298 results

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Page 1
Understanding p53 functions through p53 antibodies.
Sabapathy K, Lane DP. Sabapathy K, et al. J Mol Cell Biol. 2019 Apr 1;11(4):317-329. doi: 10.1093/jmcb/mjz010. J Mol Cell Biol. 2019. PMID: 30907951 Free PMC article. Review.
The early anti-p53 antibodies contributed to the recognition of p53 accumulation as a common feature of cancer cells and to our understanding of p53 DNA-binding and transcription activities. They led to the concept that conformational changes can facilitate …
The early anti-p53 antibodies contributed to the recognition of p53 accumulation as a common feature of cancer cells and to ou …
Treating p53 Mutant Aggregation-Associated Cancer.
Kanapathipillai M. Kanapathipillai M. Cancers (Basel). 2018 May 23;10(6):154. doi: 10.3390/cancers10060154. Cancers (Basel). 2018. PMID: 29789497 Free PMC article. Review.
p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. ...In this review, we highlight the recent efforts in targeting p53 aggregation in cancer and propose the use of small stre …
p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DN …
The crisscross between p53 and metabolism in cancer.
Mao Y, Jiang P. Mao Y, et al. Acta Biochim Biophys Sin (Shanghai). 2023 Jun 19;55(6):914-922. doi: 10.3724/abbs.2023109. Acta Biochim Biophys Sin (Shanghai). 2023. PMID: 37337630 Free PMC article. Review.
In contrast, mutant p53 proteins, especially those harboring missense mutations, have completely different functions compared to wild-type p53. ...To illustrate the variability and complexity of p53 function in metabolism, we will also review the differential …
In contrast, mutant p53 proteins, especially those harboring missense mutations, have completely different functions compared to wild …
Surfing the p53 network.
Vogelstein B, Lane D, Levine AJ. Vogelstein B, et al. Nature. 2000 Nov 16;408(6810):307-10. doi: 10.1038/35042675. Nature. 2000. PMID: 11099028 No abstract available.
The Basally Expressed p53-Mediated Homeostatic Function.
Nagpal I, Yuan ZM. Nagpal I, et al. Front Cell Dev Biol. 2021 Nov 23;9:775312. doi: 10.3389/fcell.2021.775312. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34888311 Free PMC article. Review.
Apart from mutations in the p53 gene, p53 functions can be alternatively compromised by a decrease in nuclear p53 protein levels or activities. ...The close association between p53 downregulation and carcinogenesis implicates a critical role of basally …
Apart from mutations in the p53 gene, p53 functions can be alternatively compromised by a decrease in nuclear p53 prote …
Regulation of p53 Function by Formation of Non-Nuclear Heterologous Protein Complexes.
Zavileyskiy L, Bunik V. Zavileyskiy L, et al. Biomolecules. 2022 Feb 18;12(2):327. doi: 10.3390/biom12020327. Biomolecules. 2022. PMID: 35204825 Free PMC article. Review.
Redox sensitivity of p53 functions is supported by (i) thioredoxin-dependent reduction of p53 disulfides, (ii) inhibition of the thioredoxin-dependent deoxyribonucleotide synthesis by p53 binding to RRM2B and (iii) changed intracellular distribution of p53 …
Redox sensitivity of p53 functions is supported by (i) thioredoxin-dependent reduction of p53 disulfides, (ii) inhibition of t …
Small molecule activators of the p53 response.
Ladds MJGW, Laín S. Ladds MJGW, et al. J Mol Cell Biol. 2019 Mar 1;11(3):245-254. doi: 10.1093/jmcb/mjz006. J Mol Cell Biol. 2019. PMID: 30689917 Free PMC article. Review.
Drugging the p53 pathway has been a goal for both academics and pharmaceutical companies since the designation of p53 as the 'guardian of the genome'. Through growing understanding of p53 biology, we can see multiple routes for activation of both wild-type …
Drugging the p53 pathway has been a goal for both academics and pharmaceutical companies since the designation of p53 as the ' …
Relevance of the p53-MDM2 axis to aging.
Wu D, Prives C. Wu D, et al. Cell Death Differ. 2018 Jan;25(1):169-179. doi: 10.1038/cdd.2017.187. Epub 2017 Dec 1. Cell Death Differ. 2018. PMID: 29192902 Free PMC article. Review.
Although the link between p53 and cancer is well established, the contribution of p53 to the aging process is less clear. ...We speculate that p53-mediated aging phenotypes in these mice must have (1) stably active p53 due to MDM2 dysregulation or chro …
Although the link between p53 and cancer is well established, the contribution of p53 to the aging process is less clear. ...W …
[p53].
Takahashi R. Takahashi R. Gan To Kagaku Ryoho. 1997 Sep;24(11):1381-5. Gan To Kagaku Ryoho. 1997. PMID: 9309129 Review. Japanese.
The gene coding p53 is commonly affected by deletions, rearrangements, or point mutations in a variety of human cancers. p53 is a nuclear phosphoprotein. Mutations are frequently found at highly conserved residues of the p53 protein. The mutant p53 pro …
The gene coding p53 is commonly affected by deletions, rearrangements, or point mutations in a variety of human cancers. p53 i …
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