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1964 5
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1973 22
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1975 47
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1998 329
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2000 340
2001 349
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2003 348
2004 381
2005 437
2006 518
2007 513
2008 482
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The following term was not found in PubMed: hexapeptide-19
Page 1
Protein palmitoylation and cancer.
Ko PJ, Dixon SJ. Ko PJ, et al. EMBO Rep. 2018 Oct;19(10):e46666. doi: 10.15252/embr.201846666. Epub 2018 Sep 19. EMBO Rep. 2018. PMID: 30232163 Free PMC article. Review.
S-palmitoylation is essential for the function of both oncogenes (e.g., NRAS and EGFR) and tumor suppressors (e.g., SCRIB, melanocortin 1 receptor). ...These enzymes modulate the function of important oncogenes and tumor suppressors and often display altered expression pat …
S-palmitoylation is essential for the function of both oncogenes (e.g., NRAS and EGFR) and tumor suppressors (e.g., SCRIB, melanocort …
Protein palmitoylation in cancer: molecular functions and therapeutic potential.
Zhou B, Hao Q, Liang Y, Kong E. Zhou B, et al. Mol Oncol. 2023 Jan;17(1):3-26. doi: 10.1002/1878-0261.13308. Epub 2022 Sep 10. Mol Oncol. 2023. PMID: 36018061 Free PMC article. Review.
Protein S-palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible lipid posttranslational modification catalyzed by the zinc finger DHHC-type containing (ZDHHC) protein family. ...Here we review the current literature on protein palmito …
Protein S-palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible lipid posttranslational modificat …
ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation.
Shi C, Yang X, Liu Y, Li H, Chu H, Li G, Yin H. Shi C, et al. EMBO J. 2022 Jun 1;41(11):e109272. doi: 10.15252/embj.2021109272. Epub 2022 Apr 19. EMBO J. 2022. PMID: 35438208 Free PMC article.
Double-stranded DNA is recognized as a danger signal by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS), triggering innate immune responses. Palmitoylation is an important post-translational modification (PTM) catalyzed by DHHC-palmitoyl trans …
Double-stranded DNA is recognized as a danger signal by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS), triggering i …
Palmitoyltransferase DHHC9 and acyl protein thioesterase APT1 modulate renal fibrosis through regulating beta-catenin palmitoylation.
Gu M, Jiang H, Tan M, Yu L, Xu N, Li Y, Wu H, Hou Q, Dai C. Gu M, et al. Nat Commun. 2023 Oct 21;14(1):6682. doi: 10.1038/s41467-023-42476-z. Nat Commun. 2023. PMID: 37865665 Free PMC article.
palmitoylation, a reversible post-translational modification, is initiated by the DHHC family of palmitoyltransferases and reversed by several acyl protein thioesterases. However, the role and mechanisms for protein palmitoylation in renal fibrosis have not been elu …
palmitoylation, a reversible post-translational modification, is initiated by the DHHC family of palmitoyltransferases and reversed b …
Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy.
Liu Z, Xiao M, Mo Y, Wang H, Han Y, Zhao X, Yang X, Liu Z, Xu B. Liu Z, et al. Int J Biol Sci. 2022 May 9;18(8):3447-3457. doi: 10.7150/ijbs.72244. eCollection 2022. Int J Biol Sci. 2022. PMID: 35637973 Free PMC article. Review.
Protein palmitoylation and its modifying enzymes, including palmitoylases and depalmitoylases, are expected to be new targets for effective tumor treatment. Recognizing the significance of palmitoylation modification on protein stability, localization and downstream …
Protein palmitoylation and its modifying enzymes, including palmitoylases and depalmitoylases, are expected to be new targets for eff …
Palmitoylation promotes chaperone-mediated autophagic degradation of NLRP3 to modulate inflammation.
Wang L, Cui J. Wang L, et al. Autophagy. 2023 Oct;19(10):2821-2823. doi: 10.1080/15548627.2023.2187957. Epub 2023 Mar 22. Autophagy. 2023. PMID: 36927399 Free PMC article.
Hence, it is important to uncover the mechanisms preventing sustained NLRP3 inflammasome activation. Recently, we revealed that ZDHHC12-mediated palmitoylation enhances NLRP3 degradation through the chaperone-mediated autophagy pathway, and identified gain-of-function vari …
Hence, it is important to uncover the mechanisms preventing sustained NLRP3 inflammasome activation. Recently, we revealed that ZDHHC12-medi …
4-Octyl itaconate restricts STING activation by blocking its palmitoylation.
Su C, Cheng T, Huang J, Zhang T, Yin H. Su C, et al. Cell Rep. 2023 Sep 26;42(9):113040. doi: 10.1016/j.celrep.2023.113040. Epub 2023 Aug 24. Cell Rep. 2023. PMID: 37624697 Free article.
Mechanistically, we find that 4-OI directly alkylates STING at Cys91, blocking STING palmitoylation and oligomerization. The alkylation of STING by 4-OI represents another type of post-translational modifications (PTMs) of STING. ...
Mechanistically, we find that 4-OI directly alkylates STING at Cys91, blocking STING palmitoylation and oligomerization. The alkylati …
Lipid-induced S-palmitoylation as a Vital Regulator of Cell Signaling and Disease Development.
Qu M, Zhou X, Wang X, Li H. Qu M, et al. Int J Biol Sci. 2021 Oct 11;17(15):4223-4237. doi: 10.7150/ijbs.64046. eCollection 2021. Int J Biol Sci. 2021. PMID: 34803494 Free PMC article. Review.
Recent studies have demonstrated palmitate, either from exogenous fatty acid uptake or de novo fatty acid synthesis, may serve as the substrate for protein palmitoylation and regulate protein function via palmitoylation. Palmitoylation, the most-studied prote …
Recent studies have demonstrated palmitate, either from exogenous fatty acid uptake or de novo fatty acid synthesis, may serve as the substr …
Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation.
Kim YC, Lee SE, Kim SK, Jang HD, Hwang I, Jin S, Hong EB, Jang KS, Kim HS. Kim YC, et al. Nat Chem Biol. 2019 Sep;15(9):907-916. doi: 10.1038/s41589-019-0344-0. Epub 2019 Aug 19. Nat Chem Biol. 2019. PMID: 31427815
Treatment with GSK2194069 that targets a different domain of fatty acid synthase, did not block TLR signaling or MYD88 palmitoylation. De novo fatty acid synthesis and CD36-mediated exogenous fatty acid incorporation contributed to MYD88 palmitoylation. The binding …
Treatment with GSK2194069 that targets a different domain of fatty acid synthase, did not block TLR signaling or MYD88 palmitoylation …
RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
Ren JG, Xing B, Lv K, O'Keefe RA, Wu M, Wang R, Bauer KM, Ghazaryan A, Burslem GM, Zhang J, O'Connell RM, Pillai V, Hexner EO, Philips MR, Tong W. Ren JG, et al. J Clin Invest. 2023 Jun 15;133(12):e165510. doi: 10.1172/JCI165510. J Clin Invest. 2023. PMID: 37317963 Free PMC article.
Here, we discovered that RAB27B, a RAB family small GTPase, controlled NRAS palmitoylation and trafficking to the plasma membrane, a localization required for activation. ...Mechanistically, RAB27B interacted with ZDHHC9, a palmitoyl acyltransferase that modifies NR …
Here, we discovered that RAB27B, a RAB family small GTPase, controlled NRAS palmitoylation and trafficking to the plasma membrane, a …
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