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1969 1
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1985 6
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1987 7
1988 1
1989 1
1990 2
1991 3
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54 results

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Page 1
Pantethine Ameliorates Recognition Impairment in a Mouse Model of Alzheimer's Disease by Modulating Cholesterol Content and Intestinal Flora Species.
Chen J, Li Y, Chen M, Liu X, Chen J, Li X, Wang C, Wan G, Tian J. Chen J, et al. Mol Nutr Food Res. 2023 Aug;67(15):e2200799. doi: 10.1002/mnfr.202200799. Epub 2023 Jun 2. Mol Nutr Food Res. 2023. PMID: 37194410
Pantethine reduces body weight, body fat, and the production of cholesterol in 3Tg-AD mice by inhibiting sterol regulatory element-binding protein (SREBP2) signal pathway and apolipoprotein E (APOE) expression; lipid rafts in the brain, which are necessary for the p …
Pantethine reduces body weight, body fat, and the production of cholesterol in 3Tg-AD mice by inhibiting sterol regulatory ele …
Potential antiviral effects of pantethine against SARS-CoV-2.
Abou-Hamdan M, Saleh R, Mani S, Dournaud P, Metifiot M, Blondot ML, Andreola ML, Abdel-Sater F, De Reggi M, Gressens P, Laforge M. Abou-Hamdan M, et al. Sci Rep. 2023 Feb 8;13(1):2237. doi: 10.1038/s41598-023-29245-0. Sci Rep. 2023. PMID: 36754974 Free PMC article.
SARS-CoV-2 interacts with cellular cholesterol during many stages of its replication cycle. Pantethine was reported to reduce total cholesterol levels and fatty acid synthesis and potentially alter different processes that might be involved in the SARS-CoV-2 …
SARS-CoV-2 interacts with cellular cholesterol during many stages of its replication cycle. Pantethine was reported to reduce …
Effect of pantethine on the biosynthesis of cholesterol in human skin fibroblasts.
Ranganathan S, Jackson RL, Harmony JA. Ranganathan S, et al. Atherosclerosis. 1982 Sep;44(3):261-73. doi: 10.1016/0021-9150(82)90002-8. Atherosclerosis. 1982. PMID: 7150392
Pantethine [D-bis-(N-pantothenyl-beta-aminoethyl)-disulfide] is a compound used clinically to decrease plasma triglycerides and to increase HDL cholesterol. To understand the mechanism of action of this drug, its effect on the synthesis of cholesterol in cult …
Pantethine [D-bis-(N-pantothenyl-beta-aminoethyl)-disulfide] is a compound used clinically to decrease plasma triglycerides and to in …
Pantethine inhibits cholesterol and fatty acid syntheses and stimulates carbon dioxide formation in isolated rat hepatocytes.
Cighetti G, Del Puppo M, Paroni R, Fiorica E, Galli Kienle M. Cighetti G, et al. J Lipid Res. 1987 Feb;28(2):152-61. J Lipid Res. 1987. PMID: 3106549 Free article.
The effects of pantethine on cholesterol and fatty acid metabolism were investigated in isolated rat hepatocytes. ...Results of the effect of the acetate concentration on the incorporation of [2-14C]acetate radioactivity into CO2 and lipids in control hepatocytes al …
The effects of pantethine on cholesterol and fatty acid metabolism were investigated in isolated rat hepatocytes. ...Results o …
Pantethine reduces plasma cholesterol and the severity of arterial lesions in experimental hypercholesterolemic rabbits.
Carrara P, Matturri L, Galbussera M, Lovati MR, Franceschini G, Sirtori CR. Carrara P, et al. Atherosclerosis. 1984 Dec;53(3):255-64. doi: 10.1016/0021-9150(84)90126-6. Atherosclerosis. 1984. PMID: 6442152
Pantethine (P), a coenzyme A precursor, was administered to cholesterol-fed rabbits (0.5% cholesterol diet + 1% pantethine) for 90 days. At the end of treatment, plasma total cholesterol levels were reduced 64.7% and the HDL/total cholesterol …
Pantethine (P), a coenzyme A precursor, was administered to cholesterol-fed rabbits (0.5% cholesterol diet + 1% pant …
Pantethine stimulates lipolysis in adipose tissue and inhibits cholesterol and fatty acid synthesis in liver and intestinal mucosa in the normolipidemic rat.
Bocos C, Herrera E. Bocos C, et al. Environ Toxicol Pharmacol. 1998 Aug 4;6(1):59-66. doi: 10.1016/s1382-6689(98)00020-9. Environ Toxicol Pharmacol. 1998. PMID: 21781882
In vitro effects of pantethine on adipose tissue lipolysis and on both hepatic and intestinal cholesterol and fatty acid synthesis in normolipidemic rats are determined and related to their respective in vivo hypolipidemic effects after acute oral administration. At …
In vitro effects of pantethine on adipose tissue lipolysis and on both hepatic and intestinal cholesterol and fatty acid synth …
Effects of pantethine on cholesterol synthesis from mevalonate in isolated rat hepatocytes.
Cighetti G, Del Puppo M, Paroni R, Galli G, Kienle MG. Cighetti G, et al. Atherosclerosis. 1986 Apr;60(1):67-77. doi: 10.1016/0021-9150(86)90089-4. Atherosclerosis. 1986. PMID: 3707674
Neither the amount of radioactivity incorporated into cholesterol and in its sterol precursors nor sterol levels were modified by pantethine when a mevalonolactone concentration (0.01 mM) that did not alter the levels of intermediates of cholesterol synthesis …
Neither the amount of radioactivity incorporated into cholesterol and in its sterol precursors nor sterol levels were modified by …
Metabolism of pantethine in cystinosis.
Wittwer CT, Gahl WA, Butler JD, Zatz M, Thoene JG. Wittwer CT, et al. J Clin Invest. 1985 Oct;76(4):1665-72. doi: 10.1172/JCI112152. J Clin Invest. 1985. PMID: 4056044 Free PMC article.
We treated four cystinotic children with 70-1,000 mg/kg per d oral D-pantethine and studied its metabolism. Pantethine was rapidly hydrolyzed to pantothenic acid and cysteamine; we could not detect pantethine in plasma after oral administration. ...Serum c …
We treated four cystinotic children with 70-1,000 mg/kg per d oral D-pantethine and studied its metabolism. Pantethine was rap …
Pantethine Alters Lipid Composition and Cholesterol Content of Membrane Rafts, With Down-Regulation of CXCL12-Induced T Cell Migration.
van Gijsel-Bonnello M, Acar N, Molino Y, Bretillon L, Khrestchatisky M, de Reggi M, Gharib B. van Gijsel-Bonnello M, et al. J Cell Physiol. 2015 Oct;230(10):2415-25. doi: 10.1002/jcp.24971. J Cell Physiol. 2015. PMID: 25728249
Pantethine, a natural low-molecular-weight thiol, shows a broad activity in a large range of essential cellular pathways. ...In the present study, we looked at its effects on membrane lipid rafts that serve as platforms for molecules engaged in cell activity, therefore pro …
Pantethine, a natural low-molecular-weight thiol, shows a broad activity in a large range of essential cellular pathways. ...In the p …
Effect of pantethine on cholesterol ester metabolism in rat arterial wall.
Shinomiya M, Matsuoka N, Shirai K, Morisaki N, Sasaki N, Murano S, Saito Y, Kumagai A. Shinomiya M, et al. Atherosclerosis. 1980 May;36(1):75-80. doi: 10.1016/0021-9150(80)90200-2. Atherosclerosis. 1980. PMID: 7387778
The total serum cholesterol level in rats fed on a high cholesterol diet (HCD) for 16 weeks was markedly higher than that in rats fed on a normal diet (ND), but pantethine reduced the increased level in rats fed on HCD (P less than 0.05). ...Acid CEase activi …
The total serum cholesterol level in rats fed on a high cholesterol diet (HCD) for 16 weeks was markedly higher than that in r …
54 results