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Showing results for paracetamol formalin
Your search for paracetamol-farmalid retrieved no results
Involvement of 5-HT(1A/1B) receptors in the antinociceptive effect of paracetamol in the rat formalin test.
Roca-Vinardell A, Berrocoso E, Llorca-Torralba M, García-Partida JA, Gibert-Rahola J, Mico JA. Roca-Vinardell A, et al. Neurobiol Pain. 2018 Feb 1;3:15-21. doi: 10.1016/j.ynpai.2018.01.004. eCollection 2018 Jan-Jul. Neurobiol Pain. 2018. PMID: 31194055 Free PMC article.
We demonstrated that paracetamol administration showed a dose-dependent antinociceptive effect in the formalin test. ...These results suggest that the antinociceptive effect of paracetamol can be enhanced mainly by compounds having 5-HT(1A) antagonist propert …
We demonstrated that paracetamol administration showed a dose-dependent antinociceptive effect in the formalin test. ...These …
Melatonin synergizes with the antinociceptive effect of N-palmitoylethanolamide and paracetamol.
Alavez-Pérez N, Patiño-Camacho IS, Granados-Soto V, Déciga-Campos M. Alavez-Pérez N, et al. Pharmazie. 2022 Sep 1;77(7):236-242. doi: 10.1691/ph.2022.2428. Pharmazie. 2022. PMID: 36199181
This study assessed the antinociceptive effects of melatonin in combination with paracetamol and N-palmitoylethanolamide (PEA) using the formalin test in mice. ...Combinations of melatonin with paracetamol or PEA also induced a concentration-dependent antinoc …
This study assessed the antinociceptive effects of melatonin in combination with paracetamol and N-palmitoylethanolamide (PEA) using …
Participation of ATP-sensitive K+ channels and mu-opioid receptors in the antinociceptive synergism of the paracetamol-tapentadol co-administration in the formalin-induced pain assay in mice.
Zapata-Morales JR, Alonso-Castro ÁJ, Pérez-Gutiérrez S, Rojas-Bedolla EI, Sánchez-Enriquez S, Rivas-Carrillo JD, Serafín-Higuera NA, Isiordia-Espinoza MA. Zapata-Morales JR, et al. Drug Dev Res. 2018 Dec;79(8):400-405. doi: 10.1002/ddr.21476. Epub 2018 Oct 26. Drug Dev Res. 2018. PMID: 30362140
Preclinical Research & Development The purpose of this study was to assess the interaction and mechanisms of action of the paracetamol-tapentadol combination in the formalin-induced pain model in mice. Paracetamol (56.23-562.3 mg/kg, i.p.) or tapentadol ( …
Preclinical Research & Development The purpose of this study was to assess the interaction and mechanisms of action of the paracetamo …
Synergistic interaction between amitriptyline and paracetamol in persistent and neuropathic pain models: An isobolografic analysis.
Garrido-Suárez BB, Garrido G, Bellma Menéndez A, Merino N, Valdés O, Delgado-Hernández R, Granados-Soto V. Garrido-Suárez BB, et al. Neurochem Int. 2021 Nov;150:105160. doi: 10.1016/j.neuint.2021.105160. Epub 2021 Aug 16. Neurochem Int. 2021. PMID: 34411687
The effects of individual and fixed-ratio of 1:1 combinations of orally administered amitriptyline and paracetamol were assayed in the two phases of the formalin test and in the chronic constriction injury (CCI) model in rats. Isobolographic analysis was employed to …
The effects of individual and fixed-ratio of 1:1 combinations of orally administered amitriptyline and paracetamol were assayed in th …
Paracetamol analogues conjugated by FAAH induce TRPV1-mediated antinociception without causing acute liver toxicity.
Å Nilsson JL, Mallet C, Shionoya K, Blomgren A, Sundin AP, Grundemar L, Boudieu L, Blomqvist A, Eschalier A, Nilsson UJ, Zygmunt PM. Å Nilsson JL, et al. Eur J Med Chem. 2021 Mar 5;213:113042. doi: 10.1016/j.ejmech.2020.113042. Epub 2020 Nov 21. Eur J Med Chem. 2021. PMID: 33257173 Free article.
However, paracetamol is also converted to the liver-toxic metabolite N-acetyl-p-benzoquinone imine already at therapeutic doses, urging for safer paracetamol analogues. ...The data support our view that analgesics and antipyretics without liver toxicity can be deriv …
However, paracetamol is also converted to the liver-toxic metabolite N-acetyl-p-benzoquinone imine already at therapeutic doses, urgi …
Orally administered paracetamol does not act locally in the rat formalin test: evidence for a supraspinal, serotonin-dependent antinociceptive mechanism.
Bonnefont J, Alloui A, Chapuy E, Clottes E, Eschalier A. Bonnefont J, et al. Anesthesiology. 2003 Oct;99(4):976-81. doi: 10.1097/00000542-200310000-00034. Anesthesiology. 2003. PMID: 14508334 Free article.
BACKGROUND: The mechanism of action of paracetamol (acetaminophen) remains elusive because it is still under discussion as to whether it acts locally and/or centrally. ...CONCLUSIONS: Orally administered paracetamol does not seem to exert any relevant local a …
BACKGROUND: The mechanism of action of paracetamol (acetaminophen) remains elusive because it is still under discussion as to …
Naloxone-reversible antinociception by paracetamol in the rat.
Pini LA, Vitale G, Ottani A, Sandrini M. Pini LA, et al. J Pharmacol Exp Ther. 1997 Feb;280(2):934-40. J Pharmacol Exp Ther. 1997. PMID: 9023309
Paracetamol at the dose of 400 mg/kg i.p. displayed antinociceptive activity in the hot-plate test and the formalin test. ...Pretreatment with naloxone abolished this antinociceptive activity both in the hot-plate test and in the first phase of the formalin t …
Paracetamol at the dose of 400 mg/kg i.p. displayed antinociceptive activity in the hot-plate test and the formalin test. ...P …
Anti-inflammatory and antinociceptive effects, and safety toxicological profile of a new paracetamol analog, LQFM291.
Turones LC, Machado LS, Vaz BG, de Almeida R Oliveira G, da Silva Moreira LK, Almeida DS, Martins AN, Fajemiroye JO, Martins JLR, Ghedini PC, Campos HM, Dos Santos FCA, da Silva CRB, Lião LM, Gil ES, Costa EA, Menegatti R. Turones LC, et al. Inflammopharmacology. 2023 Oct;31(5):2451-2465. doi: 10.1007/s10787-023-01324-8. Epub 2023 Sep 4. Inflammopharmacology. 2023. PMID: 37667090
The toxicologic potential of LQFM291 was also evaluated and compared to paracetamol through biochemical and histopathological analysis after the repeated treatment schedule. As a result of the acute treatment, paracetamol showed a similar antinociceptive effect in …
The toxicologic potential of LQFM291 was also evaluated and compared to paracetamol through biochemical and histopathological analysi …
Interactions between Paracetamol and Formaldehyde: Theoretical Investigation and Topological Analysis.
Nguyen TH, Nguyen TH, Le TTT, Vu Dang H, Nguyen HMT. Nguyen TH, et al. ACS Omega. 2023 Mar 22;8(13):11725-11735. doi: 10.1021/acsomega.2c05023. eCollection 2023 Apr 4. ACS Omega. 2023. PMID: 37033805 Free PMC article.
In this work, noncovalent interactions including hydrogen bonds, C...C, N...O, and van der Waals forces between paracetamol and formaldehyde were investigated using the second-order perturbation theory MP2 in conjunction with the correlation consistent basis sets (a …
In this work, noncovalent interactions including hydrogen bonds, C...C, N...O, and van der Waals forces between paracetamol and fo …
The antinociceptive action of paracetamol is associated with changes in the serotonergic system in the rat brain.
Pini LA, Sandrini M, Vitale G. Pini LA, et al. Eur J Pharmacol. 1996 Jul 11;308(1):31-40. doi: 10.1016/0014-2999(96)00261-0. Eur J Pharmacol. 1996. PMID: 8836629
The antinociceptive activity of paracetamol in the hot plate and formalin tests was studied to establish the relationship between antinociceptive activity and the central serotonergic system. Significant antinociceptive activity of paracetamol was observed in …
The antinociceptive activity of paracetamol in the hot plate and formalin tests was studied to establish the relationship betw …
123 results