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Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.
WHO Solidarity Trial Consortium; Pan H, Peto R, Henao-Restrepo AM, Preziosi MP, Sathiyamoorthy V, Abdool Karim Q, Alejandria MM, Hernández García C, Kieny MP, Malekzadeh R, Murthy S, Reddy KS, Roses Periago M, Abi Hanna P, Ader F, Al-Bader AM, Alhasawi A, Allum E, Alotaibi A, Alvarez-Moreno CA, Appadoo S, Asiri A, Aukrust P, Barratt-Due A, Bellani S, Branca M, Cappel-Porter HBC, Cerrato N, Chow TS, Como N, Eustace J, García PJ, Godbole S, Gotuzzo E, Griskevicius L, Hamra R, Hassan M, Hassany M, Hutton D, Irmansyah I, Jancoriene L, Kirwan J, Kumar S, Lennon P, Lopardo G, Lydon P, Magrini N, Maguire T, Manevska S, Manuel O, McGinty S, Medina MT, Mesa Rubio ML, Miranda-Montoya MC, Nel J, Nunes EP, Perola M, Portolés A, Rasmin MR, Raza A, Rees H, Reges PPS, Rogers CA, Salami K, Salvadori MI, Sinani N, Sterne JAC, Stevanovikj M, Tacconelli E, Tikkinen KAO, Trelle S, Zaid H, Røttingen JA, Swaminathan S. WHO Solidarity Trial Consortium, et al. N Engl J Med. 2021 Feb 11;384(6):497-511. doi: 10.1056/NEJMoa2023184. Epub 2020 Dec 2. N Engl J Med. 2021. PMID: 33264556 Free PMC article. Clinical Trial.
Unearthing real-time 3D ant tunneling mechanics.
Buarque de Macedo R, Andò E, Joy S, Viggiani G, Pal RK, Parker J, Andrade JE. Buarque de Macedo R, et al. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2102267118. doi: 10.1073/pnas.2102267118. Proc Natl Acad Sci U S A. 2021. PMID: 34426523 Free PMC article.
We discover that intergranular forces decrease significantly around ant tunnels due to arches forming within the soil. Due to this force relaxation, any grain the ants pick from the tunnel surface will likely be under low stress. Thus, ants avoid removing grains compressed …
We discover that intergranular forces decrease significantly around ant tunnels due to arches forming within the soil. Due to this fo …
EFEMP1 haploinsufficiency causes a Marfan-like hereditary connective tissue disorder.
Forghani I, Lang SH, Rodier MJ, Bivona SA; Undiagnosed Diseases Network; Morales AA, Zuchner S, Bademci G, Tekin M. Forghani I, et al. Am J Med Genet A. 2024 Jun;194(6):e63556. doi: 10.1002/ajmg.a.63556. Epub 2024 Feb 13. Am J Med Genet A. 2024. PMID: 38348595
We provide strong clinical and genetic evidence for the haploinsufficiency of EFEMP1 due to nonsense-medicated decay to cause severe kyphoscoliosis, generalized hypermobility of joints, high and narrow arched palate, and potentially severe diverticulosis. To the best of ou …
We provide strong clinical and genetic evidence for the haploinsufficiency of EFEMP1 due to nonsense-medicated decay to cause severe kyphosc …
Clinical findings of 21 previously unreported probands with HNRNPU-related syndrome and comprehensive literature review.
Durkin A, Albaba S, Fry AE, Morton JE, Douglas A, Beleza A, Williams D, Volker-Touw CML, Lynch SA, Canham N, Clowes V, Straub V, Lachlan K, Gibbon F, El Gamal M, Varghese V, Parker MJ, Newbury-Ecob R, Turnpenny PD, Gardham A, Ghali N, Balasubramanian M. Durkin A, et al. Am J Med Genet A. 2020 Jul;182(7):1637-1654. doi: 10.1002/ajmg.a.61599. Epub 2020 Apr 22. Am J Med Genet A. 2020. PMID: 32319732 Free article. Review.
These probands have craniofacial dysmorphic features, in the majority including widely spaced teeth, microcephaly, high arched eyebrows, and palpebral fissure abnormalities. Many of the patients in the group also have moderate to severe ID and seizures that tend to start i …
These probands have craniofacial dysmorphic features, in the majority including widely spaced teeth, microcephaly, high arched eyebro …
Mountaineering-induced bilateral plantar paresthesia.
Henderson KK, Parker J, Heinking KP. Henderson KK, et al. J Am Osteopath Assoc. 2014 Jul;114(7):549-55. doi: 10.7556/jaoa.2014.108. J Am Osteopath Assoc. 2014. PMID: 25002447 Free article.
CONCLUSION: These preliminary findings suggest that weakened arches may contribute to mountaineering-induced plantar paresthesia. ...
CONCLUSION: These preliminary findings suggest that weakened arches may contribute to mountaineering-induced plantar paresthesia. ...
Complementary medicine products used in pregnancy and lactation and an examination of the information sources accessed pertaining to maternal health literacy: a systematic review of qualitative studies.
Barnes LAJ, Barclay L, McCaffery K, Aslani P. Barnes LAJ, et al. BMC Complement Altern Med. 2018 Jul 31;18(1):229. doi: 10.1186/s12906-018-2283-9. BMC Complement Altern Med. 2018. PMID: 30064415 Free PMC article. Review.
Women used CMPs for perceived physical, mental-emotional, spiritual and cultural benefits for their pregnancies, their own health, the health of their unborn or breastfeeding babies, and/or the breastfeeding process. Two over-arching motives were identified: 1) to protect …
Women used CMPs for perceived physical, mental-emotional, spiritual and cultural benefits for their pregnancies, their own health, the healt …
The relationship between foot arch flexibility and medial-lateral ground reaction force distribution.
Zifchock R, Parker R, Wan W, Neary M, Song J, Hillstrom H. Zifchock R, et al. Gait Posture. 2019 Mar;69:46-49. doi: 10.1016/j.gaitpost.2019.01.012. Epub 2019 Jan 10. Gait Posture. 2019. PMID: 30660951
METHODS: Twenty-five participants were classified as having stiff or flexible arches, and three dimensional kinetic data were gathered while the volunteers ran at 7 mph on an instrumented treadmill. ...RESULTS: The results suggest that individuals with relatively stiff …
METHODS: Twenty-five participants were classified as having stiff or flexible arches, and three dimensional kinetic data were gathere …
The Crocodylian proatlas functions to redistribute venous blood and cerebrospinal fluid.
Swords A, Cramberg M, Parker S, Scott A, Sopko S, Taylor E, Young BA. Swords A, et al. J Morphol. 2024 Mar;285(3):e21683. doi: 10.1002/jmor.21683. J Morphol. 2024. PMID: 38424675
Most previous studies of the proatlas have centered on its developmental, debating the relationship between the proatlas and the cervical neural arches. The present study was intended as a description of the proatlas in the American alligator (Alligator mississippiensis) a …
Most previous studies of the proatlas have centered on its developmental, debating the relationship between the proatlas and the cervical ne …
Analysis of lamprey meis genes reveals that conserved inputs from Hox, Meis and Pbx proteins control their expression in the hindbrain and neural tube.
Parker HJ, De Kumar B, Pushel I, Bronner ME, Krumlauf R. Parker HJ, et al. Dev Biol. 2021 Nov;479:61-76. doi: 10.1016/j.ydbio.2021.07.014. Epub 2021 Jul 24. Dev Biol. 2021. PMID: 34310923 Free article.
Each of the lamprey meis genes displays temporally and spatially dynamic patterns of expression, some of which are coupled to rhombomeric domains in the developing hindbrain and select pharyngeal arches. Studies of Meis loci in mouse and zebrafish have identified enhancers …
Each of the lamprey meis genes displays temporally and spatially dynamic patterns of expression, some of which are coupled to rhombomeric do …
20 results