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Year Number of Results
1970 1
1971 2
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1975 2
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1979 2
1980 1
1981 2
1982 1
1984 2
1985 1
1986 1
1987 1
1988 2
1989 1
1991 2
1992 4
1994 3
1995 2
1996 3
1997 1
1998 2
1999 1
2000 6
2001 7
2002 5
2003 6
2004 3
2005 9
2006 8
2007 13
2008 12
2009 24
2010 21
2011 23
2012 29
2013 33
2014 33
2015 39
2016 35
2017 30
2018 21
2019 30
2020 30
2021 32
2022 23
2023 7
2024 8

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Page 1
Palmitoylethanolamide: A Natural Compound for Health Management.
Clayton P, Hill M, Bogoda N, Subah S, Venkatesh R. Clayton P, et al. Int J Mol Sci. 2021 May 18;22(10):5305. doi: 10.3390/ijms22105305. Int J Mol Sci. 2021. PMID: 34069940 Free PMC article. Review.
PEA's poor oral bioavailability, a major obstacle in early research, has been overcome by advanced delivery systems now licensed as food supplements. This review summarizes the functionality of PEA, supporting its use as an important dietary supplement for lifestyle …
PEA's poor oral bioavailability, a major obstacle in early research, has been overcome by advanced delivery systems now licensed as f …
The Basal Pharmacology of Palmitoylethanolamide.
Rankin L, Fowler CJ. Rankin L, et al. Int J Mol Sci. 2020 Oct 26;21(21):7942. doi: 10.3390/ijms21217942. Int J Mol Sci. 2020. PMID: 33114698 Free PMC article. Review.
Palmitoylethanolamide (PEA, N-hexadecanoylethanolamide) is an endogenous compound belonging to the family of N-acylethanolamines. PEA has anti-inflammatory and analgesic properties and is very well tolerated in humans. ...
Palmitoylethanolamide (PEA, N-hexadecanoylethanolamide) is an endogenous compound belonging to the family of N-acylethanolamines. …
Efficacy of Palmitoylethanolamide for Pain: A Meta-Analysis.
Artukoglu BB, Beyer C, Zuloff-Shani A, Brener E, Bloch MH. Artukoglu BB, et al. Pain Physician. 2017 Jul;20(5):353-362. Pain Physician. 2017. PMID: 28727699 Free article. Review.
SETTING: This meta-analysis examined all randomized, controlled trials involving the effect of PEA on pain score. METHODS: We searched PubMed and Embase for randomized, active or placebo-controlled trials of PEA for the treatment of acute or chronic pain. ...Use of …
SETTING: This meta-analysis examined all randomized, controlled trials involving the effect of PEA on pain score. METHODS: We searche …
Palmitoylethanolamide dampens neuroinflammation and anxiety-like behavior in obese mice.
Lama A, Pirozzi C, Severi I, Morgese MG, Senzacqua M, Annunziata C, Comella F, Del Piano F, Schiavone S, Petrosino S, Mollica MP, Diano S, Trabace L, Calignano A, Giordano A, Mattace Raso G, Meli R. Lama A, et al. Brain Behav Immun. 2022 May;102:110-123. doi: 10.1016/j.bbi.2022.02.008. Epub 2022 Feb 14. Brain Behav Immun. 2022. PMID: 35176443 Free PMC article.
In the amygdala, PEA increased dopamine turnover, as well as GABA levels. PEA also counteracted the overactivation of HPA axis, reducing the expression of hypothalamic corticotropin-releasing hormone and its type 1 receptor. ...PEA limited the albumin extrava …
In the amygdala, PEA increased dopamine turnover, as well as GABA levels. PEA also counteracted the overactivation of HPA axis …
Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor.
Fonnesu R, Thunuguntla VBSC, Veeramachaneni GK, Bondili JS, La Rocca V, Filipponi C, Spezia PG, Sidoti M, Plicanti E, Quaranta P, Freer G, Pistello M, Mathai ML, Lai M. Fonnesu R, et al. Viruses. 2022 May 17;14(5):1080. doi: 10.3390/v14051080. Viruses. 2022. PMID: 35632821 Free PMC article.
Our work highlights for the first time the antiviral potency of PEA against SARS-CoV-2, exerting its activity by two different mechanisms. ...In conclusion, the present work demonstrates a novel mechanism of action for PEA as a direct and indirect antiviral agent ag …
Our work highlights for the first time the antiviral potency of PEA against SARS-CoV-2, exerting its activity by two different mechan …
Engineered Lactobacillus paracasei Producing Palmitoylethanolamide (PEA) Prevents Colitis in Mice.
Esposito G, Pesce M, Seguella L, Lu J, Corpetti C, Del Re A, De Palma FDE, Esposito G, Sanseverino W, Sarnelli G. Esposito G, et al. Int J Mol Sci. 2021 Mar 14;22(6):2945. doi: 10.3390/ijms22062945. Int J Mol Sci. 2021. PMID: 33799405 Free PMC article.
To overcome these limitations, we developed an NAPE-PLD-expressing Lactobacillus paracasei F19 (pNAPE-LP), able to produce PEA under the boost of ultra-low palmitate supply, and investigated its therapeutic potential in a murine model of UC. ...We concluded that pNA …
To overcome these limitations, we developed an NAPE-PLD-expressing Lactobacillus paracasei F19 (pNAPE-LP), able to produce PEA under …
Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders.
Assogna M, Di Lorenzo F, Martorana A, Koch G. Assogna M, et al. Biomolecules. 2022 Aug 22;12(8):1161. doi: 10.3390/biom12081161. Biomolecules. 2022. PMID: 36009055 Free PMC article. Review.
Neuroinflammation may alter synaptic transmission contributing to the progression of neurodegeneration, as largely documented in animal models and in patients' studies. In the last few years, palmitoylethanolamide (PEA), an endogenous lipid mediator, and its new composite, …
Neuroinflammation may alter synaptic transmission contributing to the progression of neurodegeneration, as largely documented in animal mode …
Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain.
Nobili S, Micheli L, Lucarini E, Toti A, Ghelardini C, Di Cesare Mannelli L. Nobili S, et al. Pharmacol Ther. 2024 Jun;258:108649. doi: 10.1016/j.pharmthera.2024.108649. Epub 2024 Apr 12. Pharmacol Ther. 2024. PMID: 38615798 Free article. Review.
Together with its relative abundance in food sources, this opened the way to the use of PEA as a pain-relieving nutritional intervention. Naive PEA is a large particle size lipid molecule with low solubility and bioavailability. Reducing particle size is a useful me …
Together with its relative abundance in food sources, this opened the way to the use of PEA as a pain-relieving nutritional intervent …
Palmitoylethanolamide gels edible oils.
Schwaller D, Sui Y, Carvalho A, Collin D, Mésini PJ. Schwaller D, et al. Food Chem. 2022 Aug 30;386:132671. doi: 10.1016/j.foodchem.2022.132671. Epub 2022 Mar 9. Food Chem. 2022. PMID: 35334321
Palmitoylethanolamide (PEA) is an endogenous compound with no adverse effect for oral intakes of a gram per day. ...The study of the gels by cryo-SEM, optical microscopy and WAXS show that PEA forms lamellar solid aggregates with widths of several tens of micrometer …
Palmitoylethanolamide (PEA) is an endogenous compound with no adverse effect for oral intakes of a gram per day. ...The study of the …
Role of palmitoylethanolamide (PEA) in depression: Translational evidence: Special Section on "Translational and Neuroscience Studies in Affective Disorders". Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders.
De Gregorio D, Manchia M, Carpiniello B, Valtorta F, Nobile M, Gobbi G, Comai S. De Gregorio D, et al. J Affect Disord. 2019 Aug 1;255:S0165-0327(18)31599-4. doi: 10.1016/j.jad.2018.10.117. Epub 2018 Oct 25. J Affect Disord. 2019. PMID: 30391203 Review.
In a translational perspective, PEA is increased in stress conditions, and a randomized, double-blind study in depressed patients indicated a fast-antidepressant action of PEA when associated with citalopram. ...CONCLUSIONS: PEA has potential antidepressant e …
In a translational perspective, PEA is increased in stress conditions, and a randomized, double-blind study in depressed patients ind …
466 results