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Pediatric lupus nephritis.
Pinheiro SVB, Dias RF, Fabiano RCG, Araujo SA, Silva ACSE. Pinheiro SVB, et al. J Bras Nefrol. 2019 Apr-Jun;41(2):252-265. doi: 10.1590/2175-8239-JBN-2018-0097. Epub 2018 Nov 14. J Bras Nefrol. 2019. PMID: 30465590 Free PMC article. Review.
Involvement of the kidneys by lupus nephritis (LN) is one of the most severe clinical manifestations seen in individuals with systemic lupus erythematosus (SLE). LN is more frequent and severe in pediatric patients and has been associated with higher m …
Involvement of the kidneys by lupus nephritis (LN) is one of the most severe clinical manifestations seen in individuals with …
Belimumab for the treatment of pediatric patients with lupus nephritis.
Stohl W, Kwok A. Stohl W, et al. Expert Opin Biol Ther. 2023 Mar;23(3):243-251. doi: 10.1080/14712598.2023.2178297. Epub 2023 Feb 17. Expert Opin Biol Ther. 2023. PMID: 36750049 Clinical Trial.
INTRODUCTION: The FDA approved the anti-BAFF monoclonal antibody, belimumab, in 2011 for adult systemic lupus erythematosus (SLE), in 2019 for pediatric SLE, in 2020 for adult lupus nephritis (LN), and in 2022 for pediatric LN. AREAS COVERED: We …
INTRODUCTION: The FDA approved the anti-BAFF monoclonal antibody, belimumab, in 2011 for adult systemic lupus erythematosus (SLE), in …
2019 Update of the Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of lupus nephritis.
Fanouriakis A, Kostopoulou M, Cheema K, Anders HJ, Aringer M, Bajema I, Boletis J, Frangou E, Houssiau FA, Hollis J, Karras A, Marchiori F, Marks SD, Moroni G, Mosca M, Parodis I, Praga M, Schneider M, Smolen JS, Tesar V, Trachana M, van Vollenhoven RF, Voskuyl AE, Teng YKO, van Leew B, Bertsias G, Jayne D, Boumpas DT. Fanouriakis A, et al. Ann Rheum Dis. 2020 Jun;79(6):713-723. doi: 10.1136/annrheumdis-2020-216924. Epub 2020 Mar 27. Ann Rheum Dis. 2020. PMID: 32220834
OBJECTIVE: To update the 2012 EULAR/ERA-EDTA recommendations for the management of lupus nephritis (LN). METHODS: Following the EULAR standardised operating procedures, a systematic literature review was performed. ...The target of therapy is complete respons …
OBJECTIVE: To update the 2012 EULAR/ERA-EDTA recommendations for the management of lupus nephritis (LN). METHODS: Following th …
Treatment of pediatric-onset lupus nephritis: a proposal of optimal therapy.
Tanaka H, Joh K, Imaizumi T. Tanaka H, et al. Clin Exp Nephrol. 2017 Oct;21(5):755-763. doi: 10.1007/s10157-017-1381-1. Epub 2017 Mar 3. Clin Exp Nephrol. 2017. PMID: 28258497 Review.
Lupus nephritis (LN) is one of the major clinical manifestations of systemic lupus erythematosus (SLE) which occurs frequently in the early stages of pediatric-onset cases. Since SLE is a chronic disease associated with frequent disease flares and effe …
Lupus nephritis (LN) is one of the major clinical manifestations of systemic lupus erythematosus (SLE) which occurs fre …
The immune cell landscape in kidneys of patients with lupus nephritis.
Arazi A, Rao DA, Berthier CC, Davidson A, Liu Y, Hoover PJ, Chicoine A, Eisenhaure TM, Jonsson AH, Li S, Lieb DJ, Zhang F, Slowikowski K, Browne EP, Noma A, Sutherby D, Steelman S, Smilek DE, Tosta P, Apruzzese W, Massarotti E, Dall'Era M, Park M, Kamen DL, Furie RA, Payan-Schober F, Pendergraft WF 3rd, McInnis EA, Buyon JP, Petri MA, Putterman C, Kalunian KC, Woodle ES, Lederer JA, Hildeman DA, Nusbaum C, Raychaudhuri S, Kretzler M, Anolik JH, Brenner MB, Wofsy D, Hacohen N, Diamond B; Accelerating Medicines Partnership in SLE network. Arazi A, et al. Nat Immunol. 2019 Jul;20(7):902-914. doi: 10.1038/s41590-019-0398-x. Epub 2019 Jun 17. Nat Immunol. 2019. PMID: 31209404 Free PMC article.
Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from health …
Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxi …
European evidence-based recommendations for the diagnosis and treatment of childhood-onset lupus nephritis: the SHARE initiative.
Groot N, de Graeff N, Marks SD, Brogan P, Avcin T, Bader-Meunier B, Dolezalova P, Feldman BM, Kone-Paut I, Lahdenne P, McCann L, Özen S, Pilkington CA, Ravelli A, Royen-Kerkhof AV, Uziel Y, Vastert BJ, Wulffraat NM, Beresford MW, Kamphuis S. Groot N, et al. Ann Rheum Dis. 2017 Dec;76(12):1965-1973. doi: 10.1136/annrheumdis-2017-211898. Epub 2017 Sep 6. Ann Rheum Dis. 2017. PMID: 28877866 Free article.
Lupus nephritis (LN) occurs in 50%-60% of patients with childhood-onset systemic lupus erythematosus (cSLE), leading to significant morbidity. ...Treatment goal should be complete renal response. Treatment of class I LN should mainly be guided b …
Lupus nephritis (LN) occurs in 50%-60% of patients with childhood-onset systemic lupus erythematosus (cSLE), leading to …
Belimumab for systemic lupus erythematosus - Focus on lupus nephritis.
Plüß M, Piantoni S, Tampe B, Kim AHJ, Korsten P. Plüß M, et al. Hum Vaccin Immunother. 2022 Nov 30;18(5):2072143. doi: 10.1080/21645515.2022.2072143. Epub 2022 May 19. Hum Vaccin Immunother. 2022. PMID: 35588699 Free PMC article. Review.
In recent years, advances in the treatment and management of patients with systemic lupus erythematosus (SLE) have improved their life expectancy and quality of life. However, lupus nephritis (LN) still represents a major life-threatening complication …
In recent years, advances in the treatment and management of patients with systemic lupus erythematosus (SLE) have improved th …
Recent advances in immunotherapies for lupus nephritis.
Kaneko M, Jackson SW. Kaneko M, et al. Pediatr Nephrol. 2023 Apr;38(4):1001-1012. doi: 10.1007/s00467-022-05670-7. Epub 2022 Jul 1. Pediatr Nephrol. 2023. PMID: 35778517 Free PMC article. Review.
Childhood-onset systemic lupus erythematosus (SLE) is characterized by increased rates of kidney involvement, termed lupus nephritis. ...Future studies are needed to define optimal patient selection, drug combinations, and treatment duration in pedi …
Childhood-onset systemic lupus erythematosus (SLE) is characterized by increased rates of kidney involvement, termed lupus …
Kidney outcomes for children with lupus nephritis.
Oni L, Wright RD, Marks S, Beresford MW, Tullus K. Oni L, et al. Pediatr Nephrol. 2021 Jun;36(6):1377-1385. doi: 10.1007/s00467-020-04686-1. Epub 2020 Jul 28. Pediatr Nephrol. 2021. PMID: 32725543 Free PMC article. Review.
Systemic lupus erythematosus is a rare lifelong multi-systemic autoimmune condition. ...The rate of CKD 5 is reported to be up to 15% and the presence of lupus nephritis (LN) has an established link with an associated increase in mortality. ...
Systemic lupus erythematosus is a rare lifelong multi-systemic autoimmune condition. ...The rate of CKD 5 is reported to be up to 15% …
The Diagnosis and Treatment of Systemic Lupus Erythematosus.
Kuhn A, Bonsmann G, Anders HJ, Herzer P, Tenbrock K, Schneider M. Kuhn A, et al. Dtsch Arztebl Int. 2015 Jun 19;112(25):423-32. doi: 10.3238/arztebl.2015.0423. Dtsch Arztebl Int. 2015. PMID: 26179016 Free PMC article. Review.
The clinical course is variable, with a broad spectrum of organ manifestations; lupus nephritis develops in about half of all patients. METHODS: This review is based on a selective search of PubMed and the Cochrane Library, including current guidelines and expert re …
The clinical course is variable, with a broad spectrum of organ manifestations; lupus nephritis develops in about half of all …
743 results