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Epiisopiloturine, an Alkaloid from Pilocarpus microphyllus, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-kappaB-MAPK Signaling Pathway in Microglial Cells.
de Sousa JAC, Azul FVCS, de Araújo AB, Tomé RC, Silva FRM, de Vasconcelos SMM, Rios FJ, Leal LKAM. de Sousa JAC, et al. Oxid Med Cell Longev. 2023 Apr 28;2023:4752502. doi: 10.1155/2023/4752502. eCollection 2023. Oxid Med Cell Longev. 2023. PMID: 37151606 Free PMC article.
Epiisopiloturine (EPI) is an imidazole alkaloid obtained as a by-product of pilocarpine extracted from Pilocarpus microphyllus (jaborandi) and has shown promising anti-inflammatory and antinociceptive properties. ...
Epiisopiloturine (EPI) is an imidazole alkaloid obtained as a by-product of pilocarpine extracted from Pilocarpus microphyllus …
Potential Distribution of Pilocarpus microphyllus in the Amazonia/Cerrado Biomes under Near-Future Climate Change Scenarios.
Monteiro WP, de Souza EB, Miranda LS, Anjos LJS, Caldeira CF. Monteiro WP, et al. Plants (Basel). 2023 May 25;12(11):2106. doi: 10.3390/plants12112106. Plants (Basel). 2023. PMID: 37299085 Free PMC article.
Pilocarpus microphyllus Stapf. ex Wardlew. (Rutaceae) is an endemic and threatened medicinal plant species from tropical Brazil. ...Based on Species Distribution Models (SDMs), we modeled the suitability of P. microphyllus's geographical distribution consider …
Pilocarpus microphyllus Stapf. ex Wardlew. (Rutaceae) is an endemic and threatened medicinal plant species from tropical Brazi …
Computational investigation of the alkaloids of Pilocarpus microphyllus species as phytopharmaceuticals for the inhibition of sterol 14alpha-demethylase protease of Trypanosoma cruzi.
de Sá ÉRA, Souza JL, Costa RKM, Barros RO, de Lima CEB, Lima FDCA, Ramos RM. de Sá ÉRA, et al. J Biomol Struct Dyn. 2023 Apr;41(6):2555-2573. doi: 10.1080/07391102.2022.2035819. Epub 2022 Feb 8. J Biomol Struct Dyn. 2023. PMID: 35132947
This study aimed to investigate, through DFT method and B3LYP hybrid functional, the physicochemical, pharmacokinetic, and pharmacodynamic properties of the alkaloids present in the leaves of the species Pilocarpus microphyllus (jaborandi) as a potential inhibitory …
This study aimed to investigate, through DFT method and B3LYP hybrid functional, the physicochemical, pharmacokinetic, and pharmacodynamic p …
In vitro effects of Pilocarpus microphyllus extracts and pilocarpine hydrochloride on Rhipicephalus (Boophilus) microplus.
Castro KN, Lima DF, Wolschick D, Andrade IM, Santos RC, Santos FJ, Veras LM, Costa-Júnior LM. Castro KN, et al. Rev Bras Parasitol Vet. 2016 Jun 7;25(2):248-53. doi: 10.1590/S1984-29612016032. Rev Bras Parasitol Vet. 2016. PMID: 27334829 Free article.
The aim of this study was to assess the activity of aqueous (AE) and ethanolic extracts (EE) and pilocarpine hydrochloride, which were extracted and isolated from Pilocarpus microphyllus (Jaborandi), respectively, on Rhipicephalus (Boophilus) microplus. ...Such resu …
The aim of this study was to assess the activity of aqueous (AE) and ethanolic extracts (EE) and pilocarpine hydrochloride, which were extra …
Anthelmintic, Antibacterial and Cytotoxicity Activity of Imidazole Alkaloids from Pilocarpus microphyllus Leaves.
Rocha JA, Andrade IM, Véras LM, Quelemes PV, Lima DF, Soares MJ, Pinto PL, Mayo SJ, Ivanova G, Rangel M, Correia M, Mafud AC, Mascarenhas YP, Delerue-Matos C, de Moraes J, Eaton P, Leite JR. Rocha JA, et al. Phytother Res. 2017 Apr;31(4):624-630. doi: 10.1002/ptr.5771. Epub 2017 Jan 23. Phytother Res. 2017. PMID: 28111828
Pilocarpus microphyllus Stapf ex Wardlew (Rutaceae), popularly known as jaborandi, is a plant native to the northern and northeastern macroregions of Brazil. ...In this work, we report the antibacterial and anthelmintic activity of five alkaloids found in P. micr …
Pilocarpus microphyllus Stapf ex Wardlew (Rutaceae), popularly known as jaborandi, is a plant native to the northern and north …
Unraveling the biosynthesis of pilocarpine in Pilocarpus microphyllus.
Sawaya AC, Costa YD, Mazzafera P. Sawaya AC, et al. Nat Prod Commun. 2015 May;10(5):721-4. Nat Prod Commun. 2015. PMID: 26058143
Pilocarpine is found exclusively in species of Pilocarpus and the presence of other imidazole alkaloids has been reported in several species of the genus. ...Based on our own previous reports and in an experiment where pilocarpine and related alkaloids (pilosine, trachyllo …
Pilocarpine is found exclusively in species of Pilocarpus and the presence of other imidazole alkaloids has been reported in several …
Development and validation of a rapid RP-HPLC-DAD analysis method for the quantification of pilocarpine in Pilocarpus microphyllus (Rutaceae).
Caldas Pereira R, Nonato CFA, Camilo CJ, Melo Coutinho HD, Rodrigues FFG, Xiao J, da Costa JGM. Caldas Pereira R, et al. Food Chem Toxicol. 2018 Sep;119:106-111. doi: 10.1016/j.fct.2018.05.023. Epub 2018 May 16. Food Chem Toxicol. 2018. PMID: 29753865
A method using high performance liquid chromatography with diode array detector (HPLC-DAD) for identification and quantification of pilocarpine in the extract of Pilocarpus microphyllus, popularly known as jaborandi. The analysis was conducted using RP-18 column (25 …
A method using high performance liquid chromatography with diode array detector (HPLC-DAD) for identification and quantification of pilocarp …
Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties.
Rocha JA, Rego NCS, Carvalho BTS, Silva FI, Sousa JA, Ramos RM, Passos ING, de Moraes J, Leite JRSA, Lima FCA. Rocha JA, et al. PLoS One. 2018 Jun 26;13(6):e0198476. doi: 10.1371/journal.pone.0198476. eCollection 2018. PLoS One. 2018. PMID: 29944674 Free PMC article.
We conducted a theoretical study of the imizadole alkaloids of Pilocarpus microphyllus (Rutaceae) with schistosomicidal properties. ...
We conducted a theoretical study of the imizadole alkaloids of Pilocarpus microphyllus (Rutaceae) with schistosomicidal proper …
Anti-inflammatory and antinociceptive activity of epiisopiloturine, an imidazole alkaloid isolated from Pilocarpus microphyllus.
Silva VG, Silva RO, Damasceno SR, Carvalho NS, Prudêncio RS, Aragão KS, Guimarães MA, Campos SA, Véras LM, Godejohann M, Leite JR, Barbosa AL, Medeiros JV. Silva VG, et al. J Nat Prod. 2013 Jun 28;76(6):1071-7. doi: 10.1021/np400099m. Epub 2013 Jun 4. J Nat Prod. 2013. PMID: 23734744
The aim of this study was to investigate the antinociceptive and anti-inflammatory activities of epiisopiloturine (1), an imidazole alkaloid found in the leaves of Pilocarpus microphyllus. The anti-inflammatory activity of 1 was evaluated using several agents that i …
The aim of this study was to investigate the antinociceptive and anti-inflammatory activities of epiisopiloturine (1), an imidazole alkaloid …
Seasonal change in main alkaloids of jaborandi (Pilocarpus microphyllus Stapf ex Wardleworth), an economically important species from the Brazilian flora.
Lima DF, de Lima LI, Rocha JA, de Andrade IM, Grazina LG, Villa C, Meira L, Véras LM, Azevedo IF, Biase AG, Costa J, Oliveira MB, Mafra I, Leite JR. Lima DF, et al. PLoS One. 2017 Feb 2;12(2):e0170281. doi: 10.1371/journal.pone.0170281. eCollection 2017. PLoS One. 2017. PMID: 28151972 Free PMC article.
Pilocarpus microphyllus Stapf ex Wardleworth (jaborandi, Rutaceae) is one of the most important Brazilian medicinal species owing to its content of pilocarpine (PIL), an alkaloid used for treating glaucoma and xerostomia. ...The aim of this work was to assess season …
Pilocarpus microphyllus Stapf ex Wardleworth (jaborandi, Rutaceae) is one of the most important Brazilian medicinal species ow …
23 results