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Year Number of Results
1953 1
1960 3
1962 1
1964 1
1966 2
1967 1
1969 3
1971 1
1972 1
1975 2
1977 1
1978 1
1980 1
1984 2
1987 2
1988 1
1991 1
1992 1
1994 1
1996 1
1998 1
2002 1
2004 1
2013 2
2014 1
2018 1
2019 2
2020 1
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2022 1
2024 0

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40 results

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Page 1
1-Formyl-7-hydroxy-6,7-dihydro-5 H-pyrrolizine (1-CHO-DHP): A Potential Proximate Carcinogenic Metabolite of Pyrrolizidine Alkaloids.
He X, Xia Q, Gamboa da Costa G, Lin G, Fu PP. He X, et al. Chem Res Toxicol. 2019 Jun 17;32(6):1193-1203. doi: 10.1021/acs.chemrestox.9b00038. Epub 2019 Jun 3. Chem Res Toxicol. 2019. PMID: 31120748
In the present study, we examined the metabolism of seven hepatocarcinogenic PAs (senecionine, intermedine, retrorsine, riddelliine, DHR, heliotrine, and senkirkine) and one noncarcinogenic PA (platyphylline) by human, rat, and mouse liver microsomes. 1-CHO-DHP was identif …
In the present study, we examined the metabolism of seven hepatocarcinogenic PAs (senecionine, intermedine, retrorsine, riddelliine, DHR, he …
Rumen Metabolism of Senecio Pyrrolizidine Alkaloids May Explain Why Cattle Tolerate Higher Doses Than Monogastric Species.
Taenzer J, Gehling M, Klevenhusen F, Saltzmann J, Dänicke S, These A. Taenzer J, et al. J Agric Food Chem. 2022 Aug 24;70(33):10111-10120. doi: 10.1021/acs.jafc.2c01332. Epub 2022 Aug 10. J Agric Food Chem. 2022. PMID: 35948427 Free PMC article.
Therefore, rumen metabolism can be considered a detoxification step, as saturated necine base structures are known as the platyphylline type, which is regarded as less or nontoxic. Individual Senecio PAs, such as jacoline, are metabolized slowly during rumen fermentation. …
Therefore, rumen metabolism can be considered a detoxification step, as saturated necine base structures are known as the platyphylline
Fluorescent lateral flow immunoassay based on gold nanocluster for detection of pyrrolizidine alkaloids.
Zheng P, Peng T, Wang J, Zhang J, Wang Z, Zhang Y, Ren Z, Wang S, Jiang H. Zheng P, et al. Mikrochim Acta. 2021 Jan 3;188(1):11. doi: 10.1007/s00604-020-04672-2. Mikrochim Acta. 2021. PMID: 33389211
Then, fluorescent gold nanoclusters (AuNCs) were conjugated with mAb as a label probe and used in establishing a qualitative and quantitative lateral flow immunoassay (AuNCs-LFIA) for the determination of four PAs (retrorsine, platyphylline, senecionine, integerrimine) in …
Then, fluorescent gold nanoclusters (AuNCs) were conjugated with mAb as a label probe and used in establishing a qualitative and quantitativ …
Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study.
Ebmeyer J, Rasinger JD, Hengstler JG, Schaudien D, Creutzenberg O, Lampen A, Braeuning A, Hessel-Pras S. Ebmeyer J, et al. Arch Toxicol. 2020 May;94(5):1739-1751. doi: 10.1007/s00204-020-02779-2. Epub 2020 May 17. Arch Toxicol. 2020. PMID: 32419051 Free PMC article.
Therefore, a 28-day subacute rat feeding study was performed with six structurally different PA heliotrine, echimidine, lasiocarpine, senecionine, senkirkine, and platyphylline, administered at not acutely toxic doses from 0.1 to 3.3 mg/kg body weight. ...Whole-genome micr …
Therefore, a 28-day subacute rat feeding study was performed with six structurally different PA heliotrine, echimidine, lasiocarpine, seneci …
Toxic Prediction of Pyrrolizidine Alkaloids and Structure-Dependent Induction of Apoptosis in HepaRG Cells.
Zheng P, Xu Y, Ren Z, Wang Z, Wang S, Xiong J, Zhang H, Jiang H. Zheng P, et al. Oxid Med Cell Longev. 2021 Jan 2;2021:8822304. doi: 10.1155/2021/8822304. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 33488944 Free PMC article.
To verify the predictive results, 4 PAs were selected to investigate cell injury and possible mechanisms of the differentiation in HepaRG cells, including retronecine type of twelve-membered cyclic diester (retrorsine), eleven-membered cyclic diester (monocrotaline), noncyclic di …
To verify the predictive results, 4 PAs were selected to investigate cell injury and possible mechanisms of the differentiation in HepaRG ce …
[New qualitative reaction for platyphylline].
KRAMARENKO VF. KRAMARENKO VF. Aptechn Delo. 1953 Mar-Apr;2(2):52-3. Aptechn Delo. 1953. PMID: 13051139 Undetermined Language. No abstract available.
Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells.
Ebmeyer J, Behrend J, Lorenz M, Günther G, Reif R, Hengstler JG, Braeuning A, Lampen A, Hessel-Pras S. Ebmeyer J, et al. Chem Biol Interact. 2019 Jan 25;298:104-111. doi: 10.1016/j.cbi.2018.11.007. Epub 2018 Nov 19. Chem Biol Interact. 2019. PMID: 30465738
By contrast, no effect was observed for the PA echimidine, heliotrine, lasiocarpine, senecionine, senkirkine and platyphylline in the absence of an external metabolizing system up to the highest tested concentration of 500 muM. ...
By contrast, no effect was observed for the PA echimidine, heliotrine, lasiocarpine, senecionine, senkirkine and platyphylline in the …
Assessment of pyrrolizidine alkaloid-induced toxicity in an in vitro screening model.
Li YH, Kan WL, Li N, Lin G. Li YH, et al. J Ethnopharmacol. 2013 Nov 25;150(2):560-7. doi: 10.1016/j.jep.2013.09.010. Epub 2013 Sep 14. J Ethnopharmacol. 2013. PMID: 24045176
RESULTS: The combination of MTT and bromodeoxyuridine incorporation (BrdU) assays demonstrated to be a suitable method to evaluate the toxic potencies of various PAs in HepG2 cells, and the results indicated that otonecine-type PA (clivorine: IC20=0.013 0.004 mM (MTT), 0.066 0.03 …
RESULTS: The combination of MTT and bromodeoxyuridine incorporation (BrdU) assays demonstrated to be a suitable method to evaluate the toxic …
40 results