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Tenuifolin ameliorates the sleep deprivation-induced cognitive deficits.
Jiang N, Zhang Y, Yao C, Liu Y, Chen Y, Chen F, Wang Y, Choudhary MI, Liu X. Jiang N, et al. Phytother Res. 2023 Feb;37(2):464-476. doi: 10.1002/ptr.7627. Epub 2023 Jan 6. Phytother Res. 2023. PMID: 36608695
Tenuifolin (TEN), a natural neuroprotective compound obtained from the Polygala tenuifolia Willd plant, has improved cognitive symptoms. However, the impact of TEN on memory impairments caused by sleep deprivation (SD) is unclear. ...
Tenuifolin (TEN), a natural neuroprotective compound obtained from the Polygala tenuifolia Willd plant, has improved cognitive …
Sedative and hypnotic effects of Polygala tenuifolia willd. saponins on insomnia mice and their targets.
Hao KX, Shen CY, Jiang JG. Hao KX, et al. J Ethnopharmacol. 2024 Apr 6;323:117618. doi: 10.1016/j.jep.2023.117618. Epub 2023 Dec 22. J Ethnopharmacol. 2024. PMID: 38141791
ETHNOPHARMACOLOGICAL RELEVANCE: Polygala tenuifolia Willd. has been widely used in the treatment of cancer, forgetfulness, depression and other diseases. AIM OF REVIEW: The purpose of this study was to investigate the sleep-enhancing effect and mechanism of P …
ETHNOPHARMACOLOGICAL RELEVANCE: Polygala tenuifolia Willd. has been widely used in the treatment of cancer, forgetfulness, dep …
Tenuigenin promotes non-rapid eye movement sleep via the GABA(A) receptor and exerts somnogenic effect in a MPTP mouse model of Parkinson's disease.
Zhang D, Zhang W, Deng S, Liu L, Wei H, Xue F, Yang H, Wang X, Fan Z. Zhang D, et al. Biomed Pharmacother. 2023 Sep;165:115259. doi: 10.1016/j.biopha.2023.115259. Epub 2023 Aug 1. Biomed Pharmacother. 2023. PMID: 37531785 Free article.
However, standard dopamine replacement therapies for the treatment of motor symptoms often prove inadequate in combating sleep disturbances. Previous studies conducted by our research group have reported the neuroprotective effects of tenuigenin, a natural extract from …
However, standard dopamine replacement therapies for the treatment of motor symptoms often prove inadequate in combating sleep distur …
A Review of Three Commonly Used Herbs Which Enhance Memory and New Evidences Which Show Their Combination Could Improve Memory in Young Animals.
Hong F, Wang L, Wu SL, Tang HC, Sha O, Wai MSM, Yew DT. Hong F, et al. Mini Rev Med Chem. 2017;17(16):1537-1547. doi: 10.2174/1389557516666160919164352. Mini Rev Med Chem. 2017. PMID: 27659250 Review.
BACKGROUND: This review looks into the herbs Gingko biloba, Polygala tenuifolia, and Lycii fructus for their widely studied neuroprotective properties. ...For the high dose group, GABA increased in the hippocampus but not prefrontal cortex, which would help induce …
BACKGROUND: This review looks into the herbs Gingko biloba, Polygala tenuifolia, and Lycii fructus for their widely studied ne …
Sedative and Hypnotic Effects and Transcriptome Analysis of Polygala tenuifolia in Aged Insomnia Rats.
Ren XJ, Wang GY, Zhang XP, Wang QQ, Peng ZP. Ren XJ, et al. Chin J Integr Med. 2020 Jun;26(6):434-441. doi: 10.1007/s11655-020-3087-6. Epub 2020 Apr 1. Chin J Integr Med. 2020. PMID: 32240473
OBJECTIVE: To study the sedative and hypnotic effects and underlying mechanisms of Polygala tenuifolia (PT) on treating aged insomnia rats. METHODS: Sixty Sprague-Dawley male rats were divided into 6 groups by a random number table, including control group, model gr …
OBJECTIVE: To study the sedative and hypnotic effects and underlying mechanisms of Polygala tenuifolia (PT) on treating aged i …
Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka.
Kuchta K, Aritake K, Urade Y, Tung NH, Yuan CS, Sasaki Y, Shimizu K, Shoyama Y. Kuchta K, et al. Front Pharmacol. 2022 Mar 4;12:779821. doi: 10.3389/fphar.2021.779821. eCollection 2021. Front Pharmacol. 2022. PMID: 35310894 Free PMC article. Review.
A significant increase in choline acetyltransferase activity and mRNA levels were observed. Polygala radix was identified as the most essential component drug in Kamiuntanto, probably due to the saponins, tenuifolin, and sinapinic acid. ...Saffron and its major constituent …
A significant increase in choline acetyltransferase activity and mRNA levels were observed. Polygala radix was identified as the most …
Anxiolytic and sedative-hypnotic activities of polygalasaponins from Polygala tenuifolia in mice.
Yao Y, Jia M, Wu JG, Zhang H, Sun LN, Chen WS, Rahman K. Yao Y, et al. Pharm Biol. 2010 Jul;48(7):801-7. doi: 10.3109/13880200903280042. Pharm Biol. 2010. PMID: 20645780
In the present study, the anxiolytic and sedative-hypnotic activities of polygalasaponins extracted from Polygala tenuifolia Willdenow (Polygalaceae) were determined in mice using hole-board, elevated plus maze, open field, and sodium pentobarbital-induced hypnosis …
In the present study, the anxiolytic and sedative-hypnotic activities of polygalasaponins extracted from Polygala tenuifolia W …
Chinese traditional formula Kaixin San suppressed ferroptosis of hippocampal neurons and cardiomyocytes in mice with paradoxical sleep deprivation.
Cao Y, Li M, Gu L, Zhao X, Zhou A, Miao Y, Wu Y, Ke Z, Hu R, Wang Z, Wu X. Cao Y, et al. J Ethnopharmacol. 2023 Mar 25;304:116034. doi: 10.1016/j.jep.2022.116034. Epub 2022 Dec 15. J Ethnopharmacol. 2023. PMID: 36529245
ETHNOPHARMACOLOGICAL RELEVANCE: Kaixin San (KXS) is one of the most famous traditional Chinese formulas prescribed by Sun Simiao in 652 Christian era. It is composed of Panax ginseng C.A.Mey, Polygala tenuifolia, Poria cocos and Acorus calamus var. angustatus Besser …
ETHNOPHARMACOLOGICAL RELEVANCE: Kaixin San (KXS) is one of the most famous traditional Chinese formulas prescribed by Sun Simiao in 652 Chri …
Tenuifolin, a saponin derived from Radix Polygalae, exhibits sleep-enhancing effects in mice.
Cao Q, Jiang Y, Cui SY, Tu PF, Chen YM, Ma XL, Cui XY, Huang YL, Ding H, Song JZ, Yu B, Sheng ZF, Wang ZJ, Xu YP, Yang G, Ye H, Hu X, Zhang YH. Cao Q, et al. Phytomedicine. 2016 Dec 15;23(14):1797-1805. doi: 10.1016/j.phymed.2016.10.015. Epub 2016 Nov 5. Phytomedicine. 2016. PMID: 27912882
BACKGROUND: Radix Polygalae, the dried root of Polygala tenuifolia, has been extensively used as a traditional Chinese medicine for promoting intelligence and tranquilization. ...After administration of tenuifolin, the cortical EEG power spectral densities during NR …
BACKGROUND: Radix Polygalae, the dried root of Polygala tenuifolia, has been extensively used as a traditional Chinese medicin …
Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji).
Kawashima K, Miyako D, Ishino Y, Makino T, Saito K, Kano Y. Kawashima K, et al. Biol Pharm Bull. 2004 Aug;27(8):1317-9. doi: 10.1248/bpb.27.1317. Biol Pharm Bull. 2004. PMID: 15305046 Free article.
3,4,5-trimethoxycinnamic acid (TMCA) is one of the constituents in Onji (roots of Polygala tenuifolia WILLD), an herbal medicine used for sedative in Japanese traditional Kampo medicine. Our previous study revealed that oral administration of this compound prolongs …
3,4,5-trimethoxycinnamic acid (TMCA) is one of the constituents in Onji (roots of Polygala tenuifolia WILLD), an herbal medici …
18 results