Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1994 2
1995 1
1996 3
1997 1
2000 1
2006 1
2008 1
2010 1
2011 2
2012 3
2013 2
2016 2
2017 1
2018 1
2020 2
2021 2
2022 1
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

27 results

Results by year

Filters applied: . Clear all
Page 1
Polygalacic acid attenuates cognitive impairment by regulating inflammation through PPARgamma/NF-kappaB signaling pathway.
Zhao T, Jia J. Zhao T, et al. CNS Neurosci Ther. 2024 Feb;30(2):e14581. doi: 10.1111/cns.14581. CNS Neurosci Ther. 2024. PMID: 38421141 Free PMC article.
AIMS: We aimed to explore the role and molecular mechanism of polygalacic acid (PA) extracted from traditional Chinese medicine Polygala tenuifolia in the treatment of Alzheimer's disease (AD). ...
AIMS: We aimed to explore the role and molecular mechanism of polygalacic acid (PA) extracted from traditional Chinese medicin …
Exploring the effects of different processing techniques on the composition and biological activity of Platycodon grandiflorus (Jacq.) A.DC. by metabonomics and pharmacologic design.
Zhang Y, Zhang Y, Liang J, Kuang HX, Xia YG. Zhang Y, et al. J Ethnopharmacol. 2022 May 10;289:114991. doi: 10.1016/j.jep.2022.114991. Epub 2022 Jan 14. J Ethnopharmacol. 2022. PMID: 35038566
Compared to the other investigated processing methods, MZI increases the potential of PG in inducing cell apoptosis and inhibiting cell proliferation by affecting the Akt and STAT3 signaling pathways. The increased levels of 3-O-beta-glucopyranosyl polygalacic acid …
Compared to the other investigated processing methods, MZI increases the potential of PG in inducing cell apoptosis and inhibiting cell prol …
Characterization of Saponins from Various Parts of Platycodon grandiflorum Using UPLC-QToF/MS.
Lee SJ, Kim HW, Lee S, Kwon RH, Na H, Kim JH, Wee CD, Yoo SM, Lee SH. Lee SJ, et al. Molecules. 2021 Dec 24;27(1):107. doi: 10.3390/molecules27010107. Molecules. 2021. PMID: 35011337 Free PMC article.
When considering three types of aglycone, the platycodigenin group (55.04 ~ 68.34%) accounted for the largest proportion of the total content, whereas the platycogenic acid A group accounted for 17.83 ~ 22.61%, and the polygalacic acid group represented 12.06 ~ 22.3 …
When considering three types of aglycone, the platycodigenin group (55.04 ~ 68.34%) accounted for the largest proportion of the total conten …
Glycosides of polygalacic acid from the stem barks of Piper guineense Schum and Thonn.
Le Doux Kamto E, Noté OP, Kinyok MJ, Wilhelm A, Mbing JN, Antheaume C, de Théodore Atchadé A, Pegnyemb DE, Ndinteh DT, Haddad M, Bonnet SL. Le Doux Kamto E, et al. Carbohydr Res. 2021 Sep;507:108374. doi: 10.1016/j.carres.2021.108374. Epub 2021 Jun 16. Carbohydr Res. 2021. PMID: 34153825
Their structures were established on the basis of extensive analysis of 1D and 2D NMR ((1)H, (13)C NMR, DEPT, COSY, TOCSY, NOESY, HSQC, HSQC-TOCSY and HMBC) and HRESIMS experiments, and by chemical evidence as 3-O-{alpha-l-rhamnopyranosyl-(1 3)-beta-d-xylopyranosyl-(1 2)-alpha-l- …
Their structures were established on the basis of extensive analysis of 1D and 2D NMR ((1)H, (13)C NMR, DEPT, COSY, TOCSY, NOESY, HSQC, HSQC …
Polygala tenuifolia: a source for anti-Alzheimer's disease drugs.
Deng X, Zhao S, Liu X, Han L, Wang R, Hao H, Jiao Y, Han S, Bai C. Deng X, et al. Pharm Biol. 2020 Dec;58(1):410-416. doi: 10.1080/13880209.2020.1758732. Pharm Biol. 2020. PMID: 32429787 Free PMC article. Review.
(Polygalaceae) is generally used to treat insomnia, memory dysfunction and neurasthenia.Objective: This review article explores the role of P. tenuifolia and its active components in anti-Alzheimer's disease.Methods: Literature for the last ten years was obtained through a search …
(Polygalaceae) is generally used to treat insomnia, memory dysfunction and neurasthenia.Objective: This review article explores the role of …
Biotransformation of Glycosylated Saponins in Balloon Flower Root Extract into 3-O-β-D-Glucopyranosyl Platycosides by Deglycosylation of Pectinase from Aspergillus aculeatus.
Ju JH, Kang SH, Kim TH, Shin KC, Oh DK. Ju JH, et al. J Microbiol Biotechnol. 2020 Jun 28;30(6):946-954. doi: 10.4014/jmb.2001.01041. J Microbiol Biotechnol. 2020. PMID: 32238760 Free PMC article.
In the present study, glycosylated platycosides in Platycodi radix extract were biotransformed into deglycosylated 3-O-beta-D-glucopyranosyl platycosides, including 3-O-beta-Dglucopyranosyl platycodigenin, 3-O-beta-D-glucopyranosyl polygalacic acid, and 3-O-beta-Dgl …
In the present study, glycosylated platycosides in Platycodi radix extract were biotransformed into deglycosylated 3-O-beta-D-glucopyranosyl …
Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/beta-catenin and MAPK signal pathways suppression.
Xu K, Ma C, Xu L, Ran J, Jiang L, He Y, Adel Abdo Moqbel S, Wang Z, Wu L. Xu K, et al. Int Immunopharmacol. 2018 Oct;63:246-252. doi: 10.1016/j.intimp.2018.08.013. Epub 2018 Aug 14. Int Immunopharmacol. 2018. PMID: 30119032
Furthermore, polygalacic acid treatment prevented the degeneration of cartilage in the rat OA model. ...These results suggest that polygalacic acid may have a therapeutic effect in OA treatment....
Furthermore, polygalacic acid treatment prevented the degeneration of cartilage in the rat OA model. ...These results suggest …
Phytotoxic triterpene saponins from Bellis longifolia, an endemic plant of Crete.
Stavropoulou MI, Angelis A, Aligiannis N, Kalpoutzakis E, Mitakou S, Duke SO, Fokialakis N. Stavropoulou MI, et al. Phytochemistry. 2017 Dec;144:71-77. doi: 10.1016/j.phytochem.2017.08.019. Epub 2017 Sep 8. Phytochemistry. 2017. PMID: 28892660
Investigation of the active fraction led to the isolation and structure elucidation of three previously undescribed triterpene saponins, 3-O-beta-D-fucopyranosyl polygalacic acid, 28-O-alpha-L-rhamnopyranosyl-(1 2)-beta-D-fucopyranosyl polygalacic acid …
Investigation of the active fraction led to the isolation and structure elucidation of three previously undescribed triterpene saponins, 3-O …
Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice.
Guo C, Shen J, Meng Z, Yang X, Li F. Guo C, et al. Phytomedicine. 2016 Feb 15;23(2):149-55. doi: 10.1016/j.phymed.2015.12.009. Epub 2016 Jan 4. Phytomedicine. 2016. PMID: 26926176
Triterpenoid saponins, the main bioactive compounds of Polygala tenuifolia Willd, are easily hydrolyzed to polygalacic acid (PA). PURPOSE: The present study was undertaken to investigate the neuroprotective effects of PA on scopolamine-induced cognitive dysfunction …
Triterpenoid saponins, the main bioactive compounds of Polygala tenuifolia Willd, are easily hydrolyzed to polygalacic acid (P …
An integrated global chemomics and system biology approach to analyze the mechanisms of the traditional Chinese medicinal preparation Eriobotrya japonica - Fritillaria usuriensis dropping pills for pulmonary diseases.
Tao J, Hou Y, Ma X, Liu D, Tong Y, Zhou H, Gao J, Bai G. Tao J, et al. BMC Complement Altern Med. 2016 Jan 8;16:4. doi: 10.1186/s12906-015-0983-y. BMC Complement Altern Med. 2016. PMID: 26742634 Free PMC article.
(Eri), peiminine from Fritillaria usuriensis Maxim. (Fri), platycodigenin and polygalacic acid from Platycodon grandiflorum (Jacq.) A. DC. (Pla) and guanosine from Pinellia ternata (Thunb.) ...
(Eri), peiminine from Fritillaria usuriensis Maxim. (Fri), platycodigenin and polygalacic acid from Platycodon grandiflorum (J …
27 results