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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 1
1962 1
1964 1
1972 1
1974 3
1975 8
1976 5
1977 2
1978 4
1980 3
1981 4
1982 2
1983 2
1984 2
1985 5
1986 2
1987 1
1988 4
1989 3
1990 4
1992 3
1994 2
1995 3
1996 2
1997 4
1998 2
2000 1
2001 2
2002 6
2003 11
2004 7
2005 6
2006 10
2007 13
2008 16
2009 14
2010 13
2011 21
2012 17
2013 16
2014 19
2015 13
2016 10
2017 6
2018 9
2019 7
2020 4
2021 3
2022 15
2023 12
2024 8

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293 results

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Page 1
A review of Formulations of Commercially Available Antibodies.
Strickley RG, Lambert WJ. Strickley RG, et al. J Pharm Sci. 2021 Jul;110(7):2590-2608.e56. doi: 10.1016/j.xphs.2021.03.017. Epub 2021 Mar 28. J Pharm Sci. 2021. PMID: 33789155 Review.
The pH range is 4.8-8.0 and the buffers or pH-modifying agents include histidine, citrate, succinate, acetate, phosphate, glutamate, adipic acid, aspartic acid, lactic acid, tromethamine, and 2-(N-morpholino)-ethanesulfonic acid. The surfactants include mostly polysorbate …
The pH range is 4.8-8.0 and the buffers or pH-modifying agents include histidine, citrate, succinate, acetate, phosphate, glutamate, …
The impact of food additives, artificial sweeteners and domestic hygiene products on the human gut microbiome and its fibre fermentation capacity.
Gerasimidis K, Bryden K, Chen X, Papachristou E, Verney A, Roig M, Hansen R, Nichols B, Papadopoulou R, Parrett A. Gerasimidis K, et al. Eur J Nutr. 2020 Oct;59(7):3213-3230. doi: 10.1007/s00394-019-02161-8. Epub 2019 Dec 18. Eur J Nutr. 2020. PMID: 31853641 Free PMC article.
Propionic acid increased with maltodextrin, aspartame-based sweetener, sodium sulphite and polysorbate-80 and butyrate decreased dramatically with cinnamaldehyde and dishwashing detergent. ...Addition of sucralose and carrageenan-kappa also increased the abundance o …
Propionic acid increased with maltodextrin, aspartame-based sweetener, sodium sulphite and polysorbate-80 and butyrate decreas …
Investigation of excipients impact on polysorbate 80 degradation in biopharmaceutical formulation buffers.
Bai L, Zhang Y, Zhang C, Lu Y, Li Z, Huang G, Meng B. Bai L, et al. J Pharm Biomed Anal. 2023 Sep 5;233:115496. doi: 10.1016/j.jpba.2023.115496. Epub 2023 May 30. J Pharm Biomed Anal. 2023. PMID: 37285658
A study on the polysorbate 80 stability in various formulation buffers commonly used in biopharmaceuticals was performed, to investigate the excipients influence on polysorbate 80 degradation. Polysorbate 80 is a common excipient in bioph …
A study on the polysorbate 80 stability in various formulation buffers commonly used in biopharmaceuticals was performed, to i …
Comparative Stability Study of Polysorbate 20 and Polysorbate 80 Related to Oxidative Degradation.
Kozuch B, Weber J, Buske J, Mäder K, Garidel P, Diederichs T. Kozuch B, et al. Pharmaceutics. 2023 Sep 16;15(9):2332. doi: 10.3390/pharmaceutics15092332. Pharmaceutics. 2023. PMID: 37765302 Free PMC article.
The surfactants polysorbate 20 (PS20) and polysorbate 80 (PS80) are utilized to stabilize protein drugs. However, concerns have been raised regarding the degradation of PSs in biologics and the potential impact on product quality. ...PS20 and PS80 in concentrations …
The surfactants polysorbate 20 (PS20) and polysorbate 80 (PS80) are utilized to stabilize protein drugs. However, concerns hav …
Polysorbate 80 and E-Ferol toxicity.
Alade SL, Brown RE, Paquet A Jr. Alade SL, et al. Pediatrics. 1986 Apr;77(4):593-7. Pediatrics. 1986. PMID: 3960626
However, this suppression was not due to the alpha-tocopherol acetate (vitamin E) component, because alpha-tocopherol acetate by itself was not inhibitory; in fact, it often enhanced the PHA response. Because a mixture of polysorbate 80 and polysorbate …
However, this suppression was not due to the alpha-tocopherol acetate (vitamin E) component, because alpha-tocopherol acetate …
Topical ocular delivery of NSAIDs.
Ahuja M, Dhake AS, Sharma SK, Majumdar DK. Ahuja M, et al. AAPS J. 2008 Jun;10(2):229-41. doi: 10.1208/s12248-008-9024-9. Epub 2008 Apr 25. AAPS J. 2008. PMID: 18437583 Free PMC article. Review.
NSAIDs used in ophthalmology, topically, are salicylic-, indole acetic-, aryl acetic-, aryl propionic- and enolic acid derivatives. ...The incompatibility of NSAID with benzalkonium chloride is avoided by using polysorbate 80, cyclodextrins or trometha …
NSAIDs used in ophthalmology, topically, are salicylic-, indole acetic-, aryl acetic-, aryl propionic- and enolic acid derivat …
Albumin nanoparticles coated with polysorbate 80 for the targeted delivery of antiepileptic drug levetiracetam into the brain.
Wilson B, Selvam J, Mukundan GK, Premakumari KB, Jenita JL. Wilson B, et al. Drug Deliv Transl Res. 2020 Dec;10(6):1853-1861. doi: 10.1007/s13346-020-00831-3. Drug Deliv Transl Res. 2020. PMID: 32783151
The LEV was given as i.v. injection in tail vein, and the formulations were the free drug, LEV-NPs, and levetiracetam-loaded albumin nanoparticles further coated with 1% polysorbate 80 (LEV-NPs-PS 80). A significant increase in LEV concentration was achieved in the …
The LEV was given as i.v. injection in tail vein, and the formulations were the free drug, LEV-NPs, and levetiracetam-loaded albumin nanopar …
Impact of Stainless Steel Exposure on the Oxidation of Polysorbate 80 in Histidine Placebo and Active Monoclonal Antibody Formulation.
Gopalrathnam G, Sharma AN, Dodd SW, Huang L. Gopalrathnam G, et al. PDA J Pharm Sci Technol. 2018 Mar-Apr;72(2):163-175. doi: 10.5731/pdajpst.2017.008284. Epub 2018 Jan 17. PDA J Pharm Sci Technol. 2018. PMID: 29343621
Rapid oxidation of polysorbate 80 in histidine buffer was observed upon brief exposure to stainless steel. ...No major polysorbate 80 degradation in histidine buffer was observed when stainless steel contact was completely absent....
Rapid oxidation of polysorbate 80 in histidine buffer was observed upon brief exposure to stainless steel. ...No major poly …
Pathogenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT).
Greinacher A, Schönborn L, Siegerist F, Steil L, Palankar R, Handtke S, Reder A, Thiele T, Aurich K, Methling K, Lalk M, Völker U, Endlich N. Greinacher A, et al. Semin Hematol. 2022 Apr;59(2):97-107. doi: 10.1053/j.seminhematol.2022.02.004. Epub 2022 Feb 23. Semin Hematol. 2022. PMID: 35512907 Free PMC article.
Further, we discuss the potential role of vaccine constituents such as glycosaminoglycans, EDTA, polysorbate 80, human cell-line proteins and nucleotides as potential binding partners of PF4. ...
Further, we discuss the potential role of vaccine constituents such as glycosaminoglycans, EDTA, polysorbate 80, human cell-li …
Mechanistic understanding of metal-catalyzed oxidation of polysorbate 80 and monoclonal antibody in biotherapeutic formulations.
Bensaid F, Dagallier C, Authelin JR, Audat H, Filipe V, Narradon C, Guibal P, Clavier S, Wils P. Bensaid F, et al. Int J Pharm. 2022 Mar 5;615:121496. doi: 10.1016/j.ijpharm.2022.121496. Epub 2022 Jan 21. Int J Pharm. 2022. PMID: 35074436
Surfactants are commonly used in biotherapeutic formulations to prevent the formation of aggregates and protect proteins from denaturation. Among them polysorbates are the most widely used. However, they are known to be prone to degradation, mainly via enzymatic hydrolysis …
Surfactants are commonly used in biotherapeutic formulations to prevent the formation of aggregates and protect proteins from denaturation. …
293 results