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Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2.
Fang Z, Peng L, Filler R, Suzuki K, McNamara A, Lin Q, Renauer PA, Yang L, Menasche B, Sanchez A, Ren P, Xiong Q, Strine M, Clark P, Lin C, Ko AI, Grubaugh ND, Wilen CB, Chen S. Fang Z, et al. Nat Commun. 2022 Jun 6;13(1):3250. doi: 10.1038/s41467-022-30878-4. Nat Commun. 2022. PMID: 35668119 Free PMC article.
Mice that received two-dose WT LNP-mRNA show a > 40-fold reduction in neutralization potency against Omicron than WT two weeks post boost, which further reduce to background level after 3 months. ...
Mice that received two-dose WT LNP-mRNA show a > 40-fold reduction in neutralization potency against Omicron than WT two weeks post
VP2 virus-like particles elicit protective immunity against duckling short beak and dwarfism syndrome in ducks.
Xiao S, Wang S, Jiang D, Cheng X, Zhu X, Lin F, Yu B, Dong H, Wang X, Munir M, Rohaim MA, Chen S, Chen S. Xiao S, et al. Transbound Emerg Dis. 2022 Mar;69(2):570-578. doi: 10.1111/tbed.14021. Epub 2021 Feb 21. Transbound Emerg Dis. 2022. PMID: 33547727
The average LPAI titre of yolk antibodies in duck eggs receiving 2 doses (first and boost doses) of the vaccine was 5.3 1.09 log2 at 4 weeks post-boost. The protective efficacy of the maternal vaccine was 87.5%-100%. These results indicate that SBDSV VLPs can be a p …
The average LPAI titre of yolk antibodies in duck eggs receiving 2 doses (first and boost doses) of the vaccine was 5.3 1.09 log2 at 4 weeks …
Effectiveness of Booster Doses of the SARS-CoV-2 Inactivated Vaccine KCONVAC against the Mutant Strains.
Xiao C, Su J, Zhang C, Huang B, Mao L, Ren Z, Bai W, Li H, Lei G, Zheng J, Chen G, Liang X, Qiu C. Xiao C, et al. Viruses. 2022 Sep 12;14(9):2016. doi: 10.3390/v14092016. Viruses. 2022. PMID: 36146822 Free PMC article.
Both humoral and cellular immunity against variants were lower than those of ancestral variants but continued to increase from day 0 to day 7 to day 50 after boost vaccination. Fifty days post-boost, the KCONVAC-vaccinated CD8 T-cell level reached 1.23-, 2.59-, 2.53 …
Both humoral and cellular immunity against variants were lower than those of ancestral variants but continued to increase from day 0 to day …
Enhanced SARS-CoV-2 IgG durability following COVID-19 mRNA booster vaccination and comparison of BNT162b2 with mRNA-1273.
Ailsworth SM, Keshavarz B, Richards NE, Workman LJ, Murphy DD, Nelson MR, Platts-Mills TAE, Wilson JM. Ailsworth SM, et al. Ann Allergy Asthma Immunol. 2023 Jan;130(1):67-73. doi: 10.1016/j.anai.2022.10.003. Epub 2022 Oct 12. Ann Allergy Asthma Immunol. 2023. PMID: 36241020 Free PMC article.
METHODS: Surrounding receipt of the second and third homologous mRNA vaccine doses, adults in an employee-based cohort provided serum and completed questionnaires, including information about previous COVID-19 infection. The IgG to S-RBD was measured using an ImmunoCAP-based s
METHODS: Surrounding receipt of the second and third homologous mRNA vaccine doses, adults in an employee-based cohort provided serum and co …
Neutralizing SARS-CoV-2 Spike Antibodies against Omicron in Paired Samples after Two or Three Doses of mRNA Vaccine.
Debes AK, Xiao S, Egbert ER, Caturegli P, Gadala A, Colantuoni E, Sitaras I, Pekosz A, Milstone AM. Debes AK, et al. Microbiol Spectr. 2022 Oct 26;10(5):e0204622. doi: 10.1128/spectrum.02046-22. Epub 2022 Oct 3. Microbiol Spectr. 2022. PMID: 36190405 Free PMC article.
Even more, the neutralizing titers were significantly higher for all variants post-boost, compared to the titers from the post-two-dose series. ...
Even more, the neutralizing titers were significantly higher for all variants post-boost, compared to the titers from the post …
Integrase Defective Lentiviral Vector as a Vaccine Platform for Delivering Influenza Antigens.
Gallinaro A, Borghi M, Bona R, Grasso F, Calzoletti L, Palladino L, Cecchetti S, Vescio MF, Macchia D, Morante V, Canitano A, Temperton N, Castrucci MR, Salvatore M, Michelini Z, Cara A, Negri D. Gallinaro A, et al. Front Immunol. 2018 Feb 5;9:171. doi: 10.3389/fimmu.2018.00171. eCollection 2018. Front Immunol. 2018. PMID: 29459873 Free PMC article.
Six months after the vaccine prime all groups were boosted with HAp alone. Cellular and antibody responses to influenza antigens were measured at different time points after the immunizations. ...The boost with HAp alone induced an increase of antibodies in all groups
Six months after the vaccine prime all groups were boosted with HAp alone. Cellular and antibody responses to influenza antigens were …
Safety and immunogenicity of mammalian cell derived and Modified Vaccinia Ankara vectored African swine fever subunit antigens in swine.
Lopera-Madrid J, Osorio JE, He Y, Xiang Z, Adams LG, Laughlin RC, Mwangi W, Subramanya S, Neilan J, Brake D, Burrage TG, Brown WC, Clavijo A, Bounpheng MA. Lopera-Madrid J, et al. Vet Immunol Immunopathol. 2017 Mar;185:20-33. doi: 10.1016/j.vetimm.2017.01.004. Epub 2017 Jan 24. Vet Immunol Immunopathol. 2017. PMID: 28241999 Free PMC article.
Although MVA-vectored p72, CD2v, and EP153R failed to induce antibody responses, interferon-gamma (IFN-gamma(+)) spot forming cell responses against all three antigens were detected one week post-boost. The highest IFN-gamma(+) spot forming cell responses were detec …
Although MVA-vectored p72, CD2v, and EP153R failed to induce antibody responses, interferon-gamma (IFN-gamma(+)) spot forming cell responses …
An attenuated virus vaccine appears safe to the central nervous system of rainbow trout (Oncorhynchus mykiss) after intranasal delivery.
Larragoite ET, Tacchi L, LaPatra SE, Salinas I. Larragoite ET, et al. Fish Shellfish Immunol. 2016 Feb;49:351-4. doi: 10.1016/j.fsi.2016.01.006. Epub 2016 Jan 6. Fish Shellfish Immunol. 2016. PMID: 26772477 Free PMC article.
In the olfactory organ, the vaccine was detected 1 and 4 days after primary I.N vaccination but not in the intramuscular (i.m) or control groups. In the brain, IHNV was detected by RT-qPCR 4 and 21 days after i.m primary vaccination. One i.m and one I.N vaccinated t …
In the olfactory organ, the vaccine was detected 1 and 4 days after primary I.N vaccination but not in the intramuscular (i.m) or control
Microneedle array design determines the induction of protective memory CD8+ T cell responses induced by a recombinant live malaria vaccine in mice.
Carey JB, Pearson FE, Vrdoljak A, McGrath MG, Crean AM, Walsh PT, Doody T, O'Mahony C, Hill AV, Moore AC. Carey JB, et al. PLoS One. 2011;6(7):e22442. doi: 10.1371/journal.pone.0022442. Epub 2011 Jul 25. PLoS One. 2011. PMID: 21799855 Free PMC article.
BACKGROUND: Vaccine delivery into the skin has received renewed interest due to ease of access to the immune system and microvasculature, however the stratum corneum (SC), must be breached for successful vaccination. ...Microneedle-mediated vaccine priming induced signific …
BACKGROUND: Vaccine delivery into the skin has received renewed interest due to ease of access to the immune system and microvasculat …