Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
2003 1
2005 5
2006 6
2007 6
2008 3
2009 6
2010 1
2011 7
2012 6
2013 10
2014 10
2015 6
2016 10
2017 5
2018 12
2019 10
2020 11
2021 8
2022 15
2023 13
2024 4

Text availability

Article attribute

Article type

Publication date

Search Results

136 results

Results by year

Filters applied: . Clear all
Page 1
PRICKLE1-Related Disorders.
Mastrangelo M, Caputi C, Esposito D, Leuzzi V. Mastrangelo M, et al. 2009 Sep 8 [updated 2022 Apr 21]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2009 Sep 8 [updated 2022 Apr 21]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301774 Free Books & Documents. Review.
DIAGNOSIS/TESTING: The diagnosis of a PRICKLE1-related disorder is established in a proband with suggestive findings and biallelic or heterozygous pathogenic variant(s) in PRICKLE1 identified by molecular genetic testing. ...PRICKLE1-related phenotypes associ …
DIAGNOSIS/TESTING: The diagnosis of a PRICKLE1-related disorder is established in a proband with suggestive findings and biallelic or …
PRICKLE1 gene methylation and abnormal transcription in Chinese patients with ankylosing spondylitis.
Zhou T, Wang X, Kong J, Yu L, Xie H, Wang F, Xu S, Shuai Z, Zhou Q, Pan F. Zhou T, et al. Immunobiology. 2023 Nov;228(6):152742. doi: 10.1016/j.imbio.2023.152742. Epub 2023 Sep 19. Immunobiology. 2023. PMID: 37742487
METHODS: A two-stage case-control design was used to detect the characteristics of methyl group and transcriptome of PRICKLE1 gene in Ankylosing spondylitis. The methylation degree of PRICKLE1 gene promoter region was tested by phosphate-sequencing, and further anal …
METHODS: A two-stage case-control design was used to detect the characteristics of methyl group and transcriptome of PRICKLE1 gene in …
Prickle1 regulates differentiation of frontal bone osteoblasts.
Wan Y, Lantz B, Cusack BJ, Szabo-Rogers HL. Wan Y, et al. Sci Rep. 2018 Dec 21;8(1):18021. doi: 10.1038/s41598-018-36742-0. Sci Rep. 2018. PMID: 30575813 Free PMC article.
The Wnt/Planar cell polarity (Wnt/PCP) signaling pathway regulates cell migration and movement in other tissues and led us to test the role of Prickle1, a core component of the Wnt/PCP pathway, in the skull. For these studies, we used the missense allele of Prickle1 …
The Wnt/Planar cell polarity (Wnt/PCP) signaling pathway regulates cell migration and movement in other tissues and led us to test the role …
PRICKLE1 FOCAD Interaction Revealed by Genome-Wide vQTL Analysis of Human Facial Traits.
Liu D, Ban HJ, El Sergani AM, Lee MK, Hecht JT, Wehby GL, Moreno LM, Feingold E, Marazita ML, Cha S, Szabo-Rogers HL, Weinberg SM, Shaffer JR. Liu D, et al. Front Genet. 2021 Aug 9;12:674642. doi: 10.3389/fgene.2021.674642. eCollection 2021. Front Genet. 2021. PMID: 34434215 Free PMC article.
We used the hypomorphic Prickle1 (Beetlejuice) (Prickle1 (Bj) ) mouse line to directly test the function of Prickle1 on the cranial base and observed wider cranial bases in Prickle1 (Bj/Bj) . Importantly, we observed that the Prickle1 and Focadh …
We used the hypomorphic Prickle1 (Beetlejuice) (Prickle1 (Bj) ) mouse line to directly test the function of Prickle1 on …
PRICKLE1, a Wnt/PCP signaling component, is overexpressed and associated with inferior prognosis in acute myeloid leukemia.
Jiang D, He Y, Mo Q, Liu E, Li X, Huang L, Zhang Q, Chen F, Li Y, Shao H. Jiang D, et al. J Transl Med. 2021 May 17;19(1):211. doi: 10.1186/s12967-021-02873-8. J Transl Med. 2021. PMID: 34001134 Free PMC article.
However, the effect of PRICKLE1 on acute myeloid leukemia (AML) remains unknown. This study aims to characterize the prognostic significance of PRICKLE1 expression in patients with AML. ...Of note, PRICKLE1 was highly expressed in drug resistant AML cells and …
However, the effect of PRICKLE1 on acute myeloid leukemia (AML) remains unknown. This study aims to characterize the prognostic signi …
PRICKLE1 promotes gastric cancer metastasis by activating mTOR signaling.
Zhou R, Tang Z, Li H, Wang X, Sun Y. Zhou R, et al. Am J Transl Res. 2021 May 15;13(5):4266-4280. eCollection 2021. Am J Transl Res. 2021. PMID: 34150013 Free PMC article.
We identified six genes associated with lymph node metastasis and predicted poor prognosis in GC patients. Finally, we focused on PRICKLE1, a cell polarity protein, which dramatically upregulated in several GC cell lines from metastatic lesions compared with those from the …
We identified six genes associated with lymph node metastasis and predicted poor prognosis in GC patients. Finally, we focused on PRICKLE …
Prickle1 as positive regulator of oligodendrocyte differentiation.
Zilkha-Falb R, Gurevich M, Hanael E, Achiron A. Zilkha-Falb R, et al. Neuroscience. 2017 Nov 19;364:107-121. doi: 10.1016/j.neuroscience.2017.09.018. Epub 2017 Sep 19. Neuroscience. 2017. PMID: 28935237
Using Prickle1 and Nfe2l3 silencing and immunocytochemistry approaches, we demonstrated that silencing of Prickle1 dramatically decreases differentiation to NG2(+)OPCs while Nfe2l3 moderately decreases as compared with control siRNA. Moreover, silencing of Prickl …
Using Prickle1 and Nfe2l3 silencing and immunocytochemistry approaches, we demonstrated that silencing of Prickle1 dramaticall …
ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer.
Daulat AM, Finetti P, Revinski D, Silveira Wagner M, Camoin L, Audebert S, Birnbaum D, Kodjabachian L, Borg JP, Bertucci F. Daulat AM, et al. Br J Cancer. 2019 Apr;120(9):931-940. doi: 10.1038/s41416-019-0448-z. Epub 2019 Apr 11. Br J Cancer. 2019. PMID: 30971775 Free PMC article.
Notably, the combined expression of ECT2 and PRICKLE1 provided a worst prognosis than PRICKLE1 expression alone in TNBC. PRICKLE1 regulated ECT2 activity and this interaction was evolutionary conserved. ...
Notably, the combined expression of ECT2 and PRICKLE1 provided a worst prognosis than PRICKLE1 expression alone in TNBC. PR …
Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5beta complex in migrating cells.
Lim BC, Matsumoto S, Yamamoto H, Mizuno H, Kikuta J, Ishii M, Kikuchi A. Lim BC, et al. J Cell Sci. 2016 Aug 15;129(16):3115-29. doi: 10.1242/jcs.185439. Epub 2016 Jul 4. J Cell Sci. 2016. PMID: 27378169
Prickle1 dynamics correlated with those of paxillin during focal adhesion disassembly. ...Knockdown of CLASPs and LL5beta suppressed Prickle1-dependent cell polarization and migration. Prickle1 localized to the membrane through its farnesyl moiety, and the me …
Prickle1 dynamics correlated with those of paxillin during focal adhesion disassembly. ...Knockdown of CLASPs and LL5beta suppressed …
PRICKLE1 Contributes to Cancer Cell Dissemination through Its Interaction with mTORC2.
Daulat AM, Bertucci F, Audebert S, Sergé A, Finetti P, Josselin E, Castellano R, Birnbaum D, Angers S, Borg JP. Daulat AM, et al. Dev Cell. 2016 May 23;37(4):311-325. doi: 10.1016/j.devcel.2016.04.011. Epub 2016 May 12. Dev Cell. 2016. PMID: 27184734 Free article.
We identify RICTOR, a member of the mTORC2 complex, as a PRICKLE1-binding partner and show that the integrity of the PRICKLE1-MINK1-RICTOR complex is required for activation of AKT, regulation of focal adhesions, and cancer cell migration. Disruption of the PRICK …
We identify RICTOR, a member of the mTORC2 complex, as a PRICKLE1-binding partner and show that the integrity of the PRICKLE1- …
136 results