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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 3
1951 22
1952 20
1953 18
1954 20
1955 24
1956 14
1957 24
1958 10
1959 7
1960 8
1961 10
1962 18
1963 35
1964 36
1965 38
1966 39
1967 44
1968 60
1969 60
1970 87
1971 91
1972 90
1973 117
1974 143
1975 139
1976 141
1977 115
1978 110
1979 126
1980 111
1981 112
1982 101
1983 114
1984 109
1985 117
1986 113
1987 109
1988 92
1989 111
1990 84
1991 98
1992 106
1993 90
1994 95
1995 73
1996 81
1997 75
1998 75
1999 64
2000 72
2001 68
2002 80
2003 72
2004 85
2005 78
2006 75
2007 85
2008 67
2009 83
2010 65
2011 76
2012 79
2013 88
2014 99
2015 79
2016 78
2017 89
2018 82
2019 78
2020 91
2021 80
2022 86
2023 86
2024 34

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5,342 results

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Page 1
Cephalosporin-probenecid drug interactions.
Brown GR. Brown GR. Clin Pharmacokinet. 1993 Apr;24(4):289-300. doi: 10.2165/00003088-199324040-00003. Clin Pharmacokinet. 1993. PMID: 8491057 Review.
The clinical relevance of the changes in cephalosporin distribution associated with probenecid administration has not been investigated. The dose and timing of probenecid administration appear to be major determinants in any possible interaction. ...Prolonged pro …
The clinical relevance of the changes in cephalosporin distribution associated with probenecid administration has not been investigat …
N-Acetylcysteine and Probenecid Adjuvant Therapy for Traumatic Brain Injury.
Clark RSB, Empey PE, Kochanek PM, Bell MJ. Clark RSB, et al. Neurotherapeutics. 2023 Oct;20(6):1529-1537. doi: 10.1007/s13311-023-01422-z. Epub 2023 Aug 18. Neurotherapeutics. 2023. PMID: 37596428 Free article. Review.
Accordingly, combination therapy using probenecid as an adjuvant with NAC represents a logical neurotherapeutic strategy for treatment of TBI (and other CNS diseases). ...In this review, we will discuss the background and rationale for combination therapy with probeneci …
Accordingly, combination therapy using probenecid as an adjuvant with NAC represents a logical neurotherapeutic strategy for treatmen …
Repurposing Probenecid to Inhibit SARS-CoV-2, Influenza Virus, and Respiratory Syncytial Virus (RSV) Replication.
Tripp RA, Martin DE. Tripp RA, et al. Viruses. 2022 Mar 15;14(3):612. doi: 10.3390/v14030612. Viruses. 2022. PMID: 35337018 Free PMC article. Review.
Although vaccines are available for SARS-CoV-2 and some influenza viruses, there is a paucity of effective antiviral drugs, while for RSV there is no vaccine available, and therapeutic treatments are very limited. We have previously shown that probenecid is safe and effect …
Although vaccines are available for SARS-CoV-2 and some influenza viruses, there is a paucity of effective antiviral drugs, while for RSV th …
Probenecid Inhibits Respiratory Syncytial Virus (RSV) Replication.
Murray J, Bergeron HC, Jones LP, Reener ZB, Martin DE, Sancilio FD, Tripp RA. Murray J, et al. Viruses. 2022 Apr 27;14(5):912. doi: 10.3390/v14050912. Viruses. 2022. PMID: 35632652 Free PMC article.
RNA viruses like SARS-CoV-2, influenza virus, and respiratory syncytial virus (RSV) are dependent on host genes for replication. We investigated if probenecid, an FDA-approved and safe urate-lowering drug that inhibits organic anion transporters (OATs) has prophylactic or …
RNA viruses like SARS-CoV-2, influenza virus, and respiratory syncytial virus (RSV) are dependent on host genes for replication. We investig …
Drug repurposing for cardiovascular diseases: New targets and indications for probenecid.
Onódi Z, Koch S, Rubinstein J, Ferdinandy P, Varga ZV. Onódi Z, et al. Br J Pharmacol. 2023 Mar;180(6):685-700. doi: 10.1111/bph.16001. Epub 2022 Dec 26. Br J Pharmacol. 2023. PMID: 36484549 Free article. Review.
Probenecid can modulate myocardial contractility and vascular tone and exerts anti-inflammatory properties. The mechanisms behind these beneficial effects might be related inhibition of inflammasomes, and to modulation purinergic-pannexin-1 signalling and TRPV2 channels, w …
Probenecid can modulate myocardial contractility and vascular tone and exerts anti-inflammatory properties. The mechanisms behind the …
Oral Probenecid for Nonhospitalized Adults with Symptomatic Mild-to-Moderate COVID-19.
Martin DE, Pandey N, Chavda P, Singh G, Sutariya R, Sancilio F, Tripp RA. Martin DE, et al. Viruses. 2023 Jul 6;15(7):1508. doi: 10.3390/v15071508. Viruses. 2023. PMID: 37515194 Free PMC article. Clinical Trial.
Patients were randomly assigned in a 1:1:1 ratio to receive either 500 mg of probenecid, 1000 mg of probenecid, or a matching placebo every 12 h for five days. ...In addition, the median time to viral clearance was significantly shorter for the probenecid 100 …
Patients were randomly assigned in a 1:1:1 ratio to receive either 500 mg of probenecid, 1000 mg of probenecid, or a matching …
The history and future of probenecid.
Robbins N, Koch SE, Tranter M, Rubinstein J. Robbins N, et al. Cardiovasc Toxicol. 2012 Mar;12(1):1-9. doi: 10.1007/s12012-011-9145-8. Cardiovasc Toxicol. 2012. PMID: 21938493 Review.
Probenecid was initially developed with the goal of reducing the renal excretion of antibiotics, specifically penicillin. ...We review the history of probenecid in this paper and its potential future uses....
Probenecid was initially developed with the goal of reducing the renal excretion of antibiotics, specifically penicillin. ...We revie …
Probenecid: an emerging tool for neuroprotection.
Colín-González AL, Santamaría A. Colín-González AL, et al. CNS Neurol Disord Drug Targets. 2013 Nov;12(7):1050-65. doi: 10.2174/18715273113129990090. CNS Neurol Disord Drug Targets. 2013. PMID: 23844693 Review.
Probenecid (PROB) has been widely used for long time for different clinical purposes, from gout treatment to designs as a coadjutant for antibiotic agents. ...
Probenecid (PROB) has been widely used for long time for different clinical purposes, from gout treatment to designs as a coadjutant …
Clinical pharmacokinetics of probenecid.
Cunningham RF, Israili ZH, Dayton PG. Cunningham RF, et al. Clin Pharmacokinet. 1981 Mar-Apr;6(2):135-51. doi: 10.2165/00003088-198106020-00004. Clin Pharmacokinet. 1981. PMID: 7011657 Review.
A review of the clinical applications and of the disposition of probenecid in man, including drug interactions, is presented. Probenecid is the classical competitive inhibitor of organic acid transport in the kidney and other organs. ...Probenecid and its oxi …
A review of the clinical applications and of the disposition of probenecid in man, including drug interactions, is presented. Prob …
Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers.
Everts RJ, Gardiner SJ, Zhang M, Begg R, Chambers ST, Turnidge J, Begg EJ. Everts RJ, et al. J Infect. 2021 Aug;83(2):182-189. doi: 10.1016/j.jinf.2021.05.037. Epub 2021 Jun 1. J Infect. 2021. PMID: 34081957
OBJECTIVES: We evaluated the effects of probenecid on the Pharmaco Kinetics (PK) and pharmacodynamics (PD) of oral cephalexin in healthy volunteers. ...Co-administration of probenecid may expand the clinical benefits of oral cephalexin....
OBJECTIVES: We evaluated the effects of probenecid on the Pharmaco Kinetics (PK) and pharmacodynamics (PD) of oral cephalexin in heal …
5,342 results

Searches related to "probenecid"