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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1950 3
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1952 20
1953 18
1954 20
1955 24
1956 14
1957 24
1958 10
1959 7
1960 8
1961 10
1962 18
1963 35
1964 36
1965 38
1966 39
1967 44
1968 60
1969 60
1970 87
1971 91
1972 90
1973 117
1974 143
1975 139
1976 141
1977 115
1978 110
1979 126
1980 111
1981 112
1982 101
1983 114
1984 109
1985 117
1986 113
1987 109
1988 92
1989 111
1990 84
1991 98
1992 106
1993 90
1994 95
1995 73
1996 81
1997 75
1998 75
1999 64
2000 72
2001 68
2002 80
2003 72
2004 85
2005 78
2006 76
2007 85
2008 67
2009 83
2010 65
2011 76
2012 79
2013 88
2014 99
2015 79
2016 78
2017 89
2018 82
2019 78
2020 91
2021 80
2022 86
2023 87
2024 65
2025 97
2026 44

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5,501 results

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Page 1
Cephalosporin-probenecid drug interactions.
Brown GR. Brown GR. Clin Pharmacokinet. 1993 Apr;24(4):289-300. doi: 10.2165/00003088-199324040-00003. Clin Pharmacokinet. 1993. PMID: 8491057 Review.
The clinical relevance of the changes in cephalosporin distribution associated with probenecid administration has not been investigated. The dose and timing of probenecid administration appear to be major determinants in any possible interaction. Studies with ceftiz …
The clinical relevance of the changes in cephalosporin distribution associated with probenecid administration has not been investigat …
Clinical pharmacokinetics of probenecid.
Cunningham RF, Israili ZH, Dayton PG. Cunningham RF, et al. Clin Pharmacokinet. 1981 Mar-Apr;6(2):135-51. doi: 10.2165/00003088-198106020-00004. Clin Pharmacokinet. 1981. PMID: 7011657 Review.
A review of the clinical applications and of the disposition of probenecid in man, including drug interactions, is presented. Probenecid is the classical competitive inhibitor of organic acid transport in the kidney and other organs. ...Probenecid and its oxi …
A review of the clinical applications and of the disposition of probenecid in man, including drug interactions, is presented. Prob …
The history and future of probenecid.
Robbins N, Koch SE, Tranter M, Rubinstein J. Robbins N, et al. Cardiovasc Toxicol. 2012 Mar;12(1):1-9. doi: 10.1007/s12012-011-9145-8. Cardiovasc Toxicol. 2012. PMID: 21938493 Review.
Probenecid was initially developed with the goal of reducing the renal excretion of antibiotics, specifically penicillin. ...We review the history of probenecid in this paper and its potential future uses....
Probenecid was initially developed with the goal of reducing the renal excretion of antibiotics, specifically penicillin. ...We revie …
Naproxen-probenecid interaction.
Runkel R, Mroszczak E, Chaplin M, Sevelius H, Segre E. Runkel R, et al. Clin Pharmacol Ther. 1978 Dec;24(6):706-13. doi: 10.1002/cpt1978246706. Clin Pharmacol Ther. 1978. PMID: 710028 No abstract available.
Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers.
Everts RJ, Gardiner SJ, Zhang M, Begg R, Chambers ST, Turnidge J, Begg EJ. Everts RJ, et al. J Infect. 2021 Aug;83(2):182-189. doi: 10.1016/j.jinf.2021.05.037. Epub 2021 Jun 1. J Infect. 2021. PMID: 34081957
OBJECTIVES: We evaluated the effects of probenecid on the Pharmaco Kinetics (PK) and pharmacodynamics (PD) of oral cephalexin in healthy volunteers. ...Co-administration of probenecid may expand the clinical benefits of oral cephalexin....
OBJECTIVES: We evaluated the effects of probenecid on the Pharmaco Kinetics (PK) and pharmacodynamics (PD) of oral cephalexin in heal …
Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers.
Everts RJ, Begg R, Gardiner SJ, Zhang M, Turnidge J, Chambers ST, Begg EJ. Everts RJ, et al. J Infect. 2020 Jan;80(1):42-53. doi: 10.1016/j.jinf.2019.09.004. Epub 2019 Sep 12. J Infect. 2020. PMID: 31521742
METHODS: Flucloxacillin 1000 mg orally was given to 11 volunteers alone while fasting ('flucloxacillin alone'), and with probenecid 500 mg orally while fasting ('probenecid fasting') and with food ('probenecid fed'). ...Probenecid may improve the appli …
METHODS: Flucloxacillin 1000 mg orally was given to 11 volunteers alone while fasting ('flucloxacillin alone'), and with probenecid 5 …
Probenecid and zidovudine metabolism.
Kornhauser DM, Petty BG, Hendrix CW, Woods AS, Nerhood LJ, Bartlett JG, Lietman PS. Kornhauser DM, et al. Lancet. 1989 Aug 26;2(8661):473-5. doi: 10.1016/s0140-6736(89)92087-4. Lancet. 1989. PMID: 2570186 Free article. Clinical Trial.
Zidovudine plasma concentrations were measured while subjects were receiving zidovudine alone, after 3 days of zidovudine plus 500 mg probenecid every 8 h, and after 3 days of zidovudine plus 500 mg probenecid plus 260 mg quinine sulphate every 8 h. A median increas …
Zidovudine plasma concentrations were measured while subjects were receiving zidovudine alone, after 3 days of zidovudine plus 500 mg pro …
Once-daily cefazolin and probenecid for skin and soft tissue infections.
Cox VC, Zed PJ. Cox VC, et al. Ann Pharmacother. 2004 Mar;38(3):458-63. doi: 10.1345/aph.1D251. Epub 2004 Jan 23. Ann Pharmacother. 2004. PMID: 14970368 Review.
Search terms included cefazolin, probenecid, cellulitis, and soft tissue infections. STUDY SELECTION AND DATA EXTRACTION: Studies that described pharmacokinetic and clinical outcomes that evaluated the use of cefazolin in conjunction with probenecid for SSTI were in …
Search terms included cefazolin, probenecid, cellulitis, and soft tissue infections. STUDY SELECTION AND DATA EXTRACTION: Studies tha …
Probenecid-clofibrate interaction.
Veenendaal JR, Brooks PM, Meffin PJ. Veenendaal JR, et al. Clin Pharmacol Ther. 1981 Mar;29(3):351-8. doi: 10.1038/clpt.1981.48. Clin Pharmacol Ther. 1981. PMID: 7471606
Clofibric acid disposition was studied in four healthy men after 1 wk of clofibrate ingestion (500 mg orally every 12 hr) with and without probenecid (500 mg orally every 6 hr). Mean (+/- SD) free clofibric acid plasma concentration in the four subjects over a dosage inter …
Clofibric acid disposition was studied in four healthy men after 1 wk of clofibrate ingestion (500 mg orally every 12 hr) with and without …
Zidovudine with probenecid.
Duckworth AS, Duckworth GW, Henderson G, Contreras G. Duckworth AS, et al. Lancet. 1990 Aug 18;336(8712):441. doi: 10.1016/0140-6736(90)91988-m. Lancet. 1990. PMID: 1974968 No abstract available.
5,501 results