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Page 1
Did you mean proline (82,534 results)?
Alpha- and beta-prodine type compounds.
BECKETT AH, CASY AF, KIRK G. BECKETT AH, et al. J Med Pharm Chem. 1959 Feb;1(1):37-58. doi: 10.1021/jm50002a004. J Med Pharm Chem. 1959. PMID: 13655028 No abstract available.
2-Azabicyclo (2.2.2)octane analogues of the prodine analgetics.
Clark CR, Holbrook JM, Borne RF. Clark CR, et al. J Med Chem. 1976 Jun;19(6):852-4. doi: 10.1021/jm00228a027. J Med Chem. 1976. PMID: 950659
The synthesis and analgetic activity of analogues of prodine-type analgetics in which the conformation of the piperidine ring is restricted in the boat form using the 2-azabicyclo (2.2.2)octane nucleus are reported. ...
The synthesis and analgetic activity of analogues of prodine-type analgetics in which the conformation of the piperidine ring is rest …
[Synthesis and CNS-activity of spirocyclic pethidine and prodine analogs].
Wünsch B, Höfner G, Bauschke G. Wünsch B, et al. Arch Pharm (Weinheim). 1993 Sep;326(9):513-8. doi: 10.1002/ardp.19933260904. Arch Pharm (Weinheim). 1993. PMID: 8239944 German.
Cyclization of 8b and 8c followed by acid hydrolysis affords the spirocyclic hemiacetals 10b and 10c which are oxidized by PCC to give the spirocyclic prodine analogues 4b and 4c. The corresponding spirocyclic pethidine derivative 2 is prepared by alkylation of the 2-benzo …
Cyclization of 8b and 8c followed by acid hydrolysis affords the spirocyclic hemiacetals 10b and 10c which are oxidized by PCC to give the s …
The Effect of PEGylation on Drugs' Pharmacokinetic Parameters; from Absorption to Excretion.
Khajeei A, Masoomzadeh S, Gholikhani T, Javadzadeh Y. Khajeei A, et al. Curr Drug Deliv. 2024;21(7):978-992. doi: 10.2174/1567201820666230621124953. Curr Drug Deliv. 2024. PMID: 37345248 Review.
For example, using different forms of a single drug molecule (like Citalopram and Escitalopram); slight changes in the drug's molecule like Meperidine and alpha-Prodine, and using carriers (like Tigerase). PEGylation is a recently presented method that can use for many tar …
For example, using different forms of a single drug molecule (like Citalopram and Escitalopram); slight changes in the drug's molecule like …
Alpha- and beta-prodine type compounds: configurational studies.
BECKETT AH, CASY AF, KIRK G, WALKER J. BECKETT AH, et al. J Pharm Pharmacol. 1957 Dec;9(12):939-48; discussion 948-9. doi: 10.1111/j.2042-7158.1957.tb12356.x. J Pharm Pharmacol. 1957. PMID: 13492182 No abstract available.
Quantum chemical studies of meperidine and prodine.
Loew GH, Jester JR. Loew GH, et al. J Med Chem. 1975 Nov;18(11):1051-6. doi: 10.1021/jm00245a001. J Med Chem. 1975. PMID: 1177250
Extensive quantum chemical calculations have been made of the electronic distribution and conformational behavior of meperidine and desmethyl-, (+)-alpha, and (+)-beta-prodine using PCILO, a semiempirical molecular orbital method. For this series of opiates, a phenyl equat …
Extensive quantum chemical calculations have been made of the electronic distribution and conformational behavior of meperidine and desmethy …
Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds.
Iorio MA, Reymer TP, Frigeni V. Iorio MA, et al. J Med Chem. 1987 Oct;30(10):1906-10. doi: 10.1021/jm00393a037. J Med Chem. 1987. PMID: 2888899
With a 3-methyl substituent on the piperidine ring, the beta-configuration was the more active form not only for analgesic activity, as expected from previous results on prodines, but also for neuroleptic activity. Haloperidol and its propionate were also tested as referen …
With a 3-methyl substituent on the piperidine ring, the beta-configuration was the more active form not only for analgesic activity, as expe …
Stereochemical studies on medicinal agents. 20. Absolute configuration and analgetic potency alpha-promedol enantiomers. The role of the C-4 chiral center in conferring stereoselectivity in axial- and equatorial-phenyl prodine congeners.
Fries DF, Portoghese PS. Fries DF, et al. J Med Chem. 1976 Sep;19(9):1155-8. doi: 10.1021/jm00231a014. J Med Chem. 1976. PMID: 978670
In contrast, the C(2)-N-C(6) portion of the axial and equatorial molecules does not bind in the same receptor environment, and it is suggested that different modes of interaction in the prodine series arise from different orientations of this moiety....
In contrast, the C(2)-N-C(6) portion of the axial and equatorial molecules does not bind in the same receptor environment, and it is suggest …
Electronic study of receptor binding of analgesic aryl moiety II: Prodine analogs.
Razzak KS, Hamid KA. Razzak KS, et al. J Pharm Sci. 1980 Jul;69(7):796-9. doi: 10.1002/jps.2600690713. J Pharm Sci. 1980. PMID: 7391942
Analogs of the prodine analgesics were prepared and tested for analgesic activity. ...
Analogs of the prodine analgesics were prepared and tested for analgesic activity. ...
200 results