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Magnolol causes alterations in the cell cycle in androgen insensitive human prostate cancer cells in vitro by affecting expression of key cell cycle regulatory proteins.
McKeown BT, McDougall L, Catalli A, Hurta RA. McKeown BT, et al. Nutr Cancer. 2014;66(7):1154-64. doi: 10.1080/01635581.2014.951736. Epub 2014 Sep 29. Nutr Cancer. 2014. PMID: 25264561
Prostate cancer, one of the most common cancers in the Western world, affects many men worldwide. ...This study has demonstrated that magnolol can alter the behavior of androgen insensitive human prostate cancer cells in vitro and suggests that …
Prostate cancer, one of the most common cancers in the Western world, affects many men worldwide. ...This study has demonstrat …
Magnolol affects expression of IGF-1 and associated binding proteins in human prostate cancer cells in vitro.
McKeown BT, Hurta RA. McKeown BT, et al. Anticancer Res. 2014 Nov;34(11):6333-8. Anticancer Res. 2014. PMID: 25368232
BACKGROUND/AIM: This study investigated the effects of magnolol, a compound from Magnolia officinalis, on the behavior of LNCaP and PC3 human prostate cancer cells in vitro. ...CONCLUSION: This study has demonstrated for the first time that magnolol ca …
BACKGROUND/AIM: This study investigated the effects of magnolol, a compound from Magnolia officinalis, on the behavior of LNCaP and P …
Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells.
Lee DH, Szczepanski MJ, Lee YJ. Lee DH, et al. J Cell Biochem. 2009 Apr 15;106(6):1113-22. doi: 10.1002/jcb.22098. J Cell Biochem. 2009. PMID: 19229860
We observed that treatment of prostate cancer cells for 24 h with magnolol, a phenolic component extracted from the root and stem bark of the oriental herb Magnolia officinalis, induced apoptotic cell death in a dose- and time-dependent manner. ...Interesting …
We observed that treatment of prostate cancer cells for 24 h with magnolol, a phenolic component extracted from the roo …
Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer.
Ranaware AM, Banik K, Deshpande V, Padmavathi G, Roy NK, Sethi G, Fan L, Kumar AP, Kunnumakkara AB. Ranaware AM, et al. Int J Mol Sci. 2018 Aug 10;19(8):2362. doi: 10.3390/ijms19082362. Int J Mol Sci. 2018. PMID: 30103472 Free PMC article. Review.
Magnolol can efficiently prevent or inhibit the growth of various cancers originating from different organs such as brain, breast, cervical, colon, liver, lung, prostate, skin, etc. ...This review proposes magnolol as a suitable candidate that can be appropri …
Magnolol can efficiently prevent or inhibit the growth of various cancers originating from different organs such as brain, breast, ce …
Magnolol suppresses metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in PC-3 human prostate carcinoma cells.
Hwang ES, Park KK. Hwang ES, et al. Biosci Biotechnol Biochem. 2010;74(5):961-7. doi: 10.1271/bbb.90785. Epub 2010 May 7. Biosci Biotechnol Biochem. 2010. PMID: 20460721 Free article.
The objective of this study was to study the effects of magnolol on cancer invasion and metastasis using PC-3 human prostate carcinoma cells. ...The protein and mRNA levels of both MMP-2 and MMP-9 were down-regulated by magnolol treatment in a dose-dep …
The objective of this study was to study the effects of magnolol on cancer invasion and metastasis using PC-3 human prostat …
Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB.
Lee SY, Yuk DY, Song HS, Yoon DY, Jung JK, Moon DC, Lee BS, Hong JT. Lee SY, et al. Eur J Pharmacol. 2008 Mar 17;582(1-3):17-25. doi: 10.1016/j.ejphar.2007.12.027. Epub 2008 Jan 5. Eur J Pharmacol. 2008. PMID: 18241858
Biphenolic components in Magnolia obovata including magnolol and honokiol have shown several pharmacological activities such as anti-tumor, anti-oxidant and anti-inflammatory effects. Previously in cultured macrophage Raw264.7 cells and fibroblast, we found that obovatol, …
Biphenolic components in Magnolia obovata including magnolol and honokiol have shown several pharmacological activities such as anti- …
[Mining and discovery for active components of "Coptidis Rhizome-Magnoliae Officinalis Cortex" based on network pharmacology].
Wu HN, Yu GH, Zhao FZ, Jia XB, Feng L, Shi XH. Wu HN, et al. Zhongguo Zhong Yao Za Zhi. 2019 Feb;44(4):803-810. doi: 10.19540/j.cnki.cjcmm.20181129.001. Zhongguo Zhong Yao Za Zhi. 2019. PMID: 30989895 Chinese.
A total of 29 potential target active ingredients were screened from " C&M",including 12 alkaloids components such as( R)-canadine,berberine,coptisine,and palmatine; 3 lignans consisting of magnolol,honokiol and obovatol; 6 volatile oils consisting of alpha-eudesmol,be …
A total of 29 potential target active ingredients were screened from " C&M",including 12 alkaloids components such as( R)-canadine,berbe …