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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1893 1
1929 1
1936 1
1945 2
1946 28
1947 26
1948 25
1949 29
1950 8
1951 20
1952 21
1953 28
1954 24
1955 27
1956 37
1957 29
1958 28
1959 15
1960 19
1961 29
1962 40
1963 31
1964 35
1965 29
1966 22
1967 33
1968 33
1969 47
1970 30
1971 39
1972 37
1973 27
1974 54
1975 82
1976 87
1977 84
1978 89
1979 85
1980 113
1981 136
1982 153
1983 241
1984 339
1985 368
1986 403
1987 440
1988 409
1989 336
1990 364
1991 378
1992 353
1993 371
1994 360
1995 388
1996 349
1997 358
1998 356
1999 355
2000 454
2001 432
2002 391
2003 475
2004 493
2005 531
2006 588
2007 662
2008 683
2009 684
2010 759
2011 880
2012 927
2013 984
2014 1009
2015 930
2016 892
2017 915
2018 917
2019 919
2020 1069
2021 985
2022 805
2023 613
2024 297

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24,044 results

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Quinoline Derivative Enhances Human Sperm Motility and Improves the Functional Competence.
Kumari S, Salian SR, Rao A, Somagond SM, Kamble RR, Nesaragi A, Das J, Rajanikant GK, Mutalik S, Raghu SV, Adiga SK, Kalthur G. Kumari S, et al. Reprod Sci. 2021 May;28(5):1316-1332. doi: 10.1007/s43032-020-00382-5. Epub 2020 Nov 25. Reprod Sci. 2021. PMID: 33237520 Free PMC article.
Nine novel quinoline derivatives were screened for their effect on motility in human spermatozoa from normozoospermic ejaculates. ...To determine the effect on the fertilizing ability of spermatozoa processed with quinoline derivatives and to assess de …
Nine novel quinoline derivatives were screened for their effect on motility in human spermatozoa from normozoospermic ejaculat …
Quinoline-derivative coordination compounds as potential applications to antibacterial and antineoplasic drugs.
Dos Santos Chagas C, Fonseca FLA, Bagatin IA. Dos Santos Chagas C, et al. Mater Sci Eng C Mater Biol Appl. 2019 May;98:1043-1052. doi: 10.1016/j.msec.2019.01.058. Epub 2019 Jan 16. Mater Sci Eng C Mater Biol Appl. 2019. PMID: 30812988
Quinoline-derivative coordination compounds were synthesized with Zn(II), Al(III), Cu(II), Ru(II) producing 1-4 compounds using 5-nitro-8-hydroxyquinoline and 5-8 compounds using 5-chloro-8-hydroxyquinoline. ...
Quinoline-derivative coordination compounds were synthesized with Zn(II), Al(III), Cu(II), Ru(II) producing 1-4 compounds usin …
A simple quinoline salt derivative is active in vitro against Plasmodiumfalciparum asexual blood stages and inhibits the development of cerebral malaria in murine model.
Bezerra Bellei JC, Glanzmann N, Carpinter BA, Renhe DC, Marques CB, Azevedo MR, Barreto LM, Rocha VN, Karine da Costa Nunes I, Gualberto Pereira HM, Coimbra ES, Ferraz Coelho EA, David da Silva A, de Pilla Varotti F, Gorza Scopel KK. Bezerra Bellei JC, et al. Chem Biol Interact. 2022 Mar 1;355:109848. doi: 10.1016/j.cbi.2022.109848. Epub 2022 Feb 9. Chem Biol Interact. 2022. PMID: 35149084
Seven compounds were synthesized, including three quinoline derivate salts. The cytotoxicity and antiplasmodial activity were assayed in vitro, highlighting compound 3 as a HIT, which also showed interaction with ferriprotoporphyrin IX similarly to CQ. ...Compound 3 …
Seven compounds were synthesized, including three quinoline derivate salts. The cytotoxicity and antiplasmodial activity were …
Enzymatic approaches to site-selective oxidation of quinoline and derivatives.
Wang Z, Zhao L, Mou X, Chen Y. Wang Z, et al. Org Biomol Chem. 2022 Mar 30;20(13):2580-2600. doi: 10.1039/d2ob00200k. Org Biomol Chem. 2022. PMID: 35290426 Review.
Enzyme-mediated oxidation has been a green and efficient strategy for preparation of derivative chemicals from quinoline and its structural analogues. Herein, we report the progress made to date in enzymatic methods to oxidation of the pyridine moieties of quinol …
Enzyme-mediated oxidation has been a green and efficient strategy for preparation of derivative chemicals from quinoline and i …
Quinoline as a privileged scaffold in cancer drug discovery.
Solomon VR, Lee H. Solomon VR, et al. Curr Med Chem. 2011;18(10):1488-508. doi: 10.2174/092986711795328382. Curr Med Chem. 2011. PMID: 21428893 Review.
This includes numerous analogues derived from substitution of the quinoline ring system, and derivatization of quinoline ring structure. ...In particular, we focus our review on in vitro and in vivo anticancer activities of quinoline and its analogs …
This includes numerous analogues derived from substitution of the quinoline ring system, and derivatization of quinoline …
A Review of Modifications of Quinoline Antimalarials: Mefloquine and (hydroxy)Chloroquine.
Kucharski DJ, Jaszczak MK, Boratyński PJ. Kucharski DJ, et al. Molecules. 2022 Feb 2;27(3):1003. doi: 10.3390/molecules27031003. Molecules. 2022. PMID: 35164267 Free PMC article. Review.
Late-stage modification of drug molecules is a fast method to introduce diversity into the already biologically active scaffold. A notable number of analogs of mefloquine, chloroquine, and hydroxychloroquine have been synthesized, starting from the readily available active …
Late-stage modification of drug molecules is a fast method to introduce diversity into the already biologically active scaffold. A notable n …
Identification of quinoline-chalcones and heterocyclic chalcone-appended quinolines as broad-spectrum pharmacological agents.
Atukuri D, S V, R S, L V, R P, M M R. Atukuri D, et al. Bioorg Chem. 2020 Dec;105:104419. doi: 10.1016/j.bioorg.2020.104419. Epub 2020 Oct 22. Bioorg Chem. 2020. PMID: 33142228 Review.
Quinoline derivatives have been reported to possess enticing pharmacological properties. ...In this review work, we focused on the recent drug discovery based on quinoline-chalcones. The work emphasizes the potency of a wide range of quinoline chalcone …
Quinoline derivatives have been reported to possess enticing pharmacological properties. ...In this review work, we focused on …
Recent Progress in the Development of Quinoline Derivatives for the Exploitation of Anti-Cancer Agents.
Man RJ, Jeelani N, Zhou C, Yang YS. Man RJ, et al. Anticancer Agents Med Chem. 2021;21(7):825-838. doi: 10.2174/1871520620666200516150345. Anticancer Agents Med Chem. 2021. PMID: 32416703 Review.
For each mechanism, the introduction of the target was presented, with the typical examples of quinoline derivate drugs. CONCLUSION: This review has highlighted the quinoline drugs or candidates, suited them into corresponding targets in their pathways, summa …
For each mechanism, the introduction of the target was presented, with the typical examples of quinoline derivate drugs. CONCL …
Discovery of a quinoline-based phenyl sulfone derivative as an antitrypanosomal agent.
Zhang H, Collins J, Nyamwihura R, Ware S, Kaiser M, Ogungbe IV. Zhang H, et al. Bioorg Med Chem Lett. 2018 May 15;28(9):1647-1651. doi: 10.1016/j.bmcl.2018.03.039. Epub 2018 Mar 24. Bioorg Med Chem Lett. 2018. PMID: 29609908 Free PMC article.
Trypanosoma brucei is a kinetoplastid protozoan parasite that causes trypanosomiasis. In this work, we found that nopol- and quinoline-based phenyl sulfone derivative were the most active and selective for T. brucei, and they were not reactive towards the active thi …
Trypanosoma brucei is a kinetoplastid protozoan parasite that causes trypanosomiasis. In this work, we found that nopol- and quinoline …
Efficacy of the 7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline derivative against infection caused by Leishmania amazonensis.
Antinarelli LMR, Souza MVN, Coelho EAF, Lima WP, Coimbra ES. Antinarelli LMR, et al. Rev Soc Bras Med Trop. 2020 Jun 22;53:e20200091. doi: 10.1590/0037-8682-0091-2020. eCollection 2020. Rev Soc Bras Med Trop. 2020. PMID: 32578713 Free PMC article.
METHODS: In vitro and in vivo studies were performed to evaluate the effect of a quinoline derivative, Hydraqui (7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline, against Leishmania amazonensis. ...
METHODS: In vitro and in vivo studies were performed to evaluate the effect of a quinoline derivative, Hydraqui (7-chloro-4-(3 …
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