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898 results

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Page 1
Rab27a and Rab27b control different steps of the exosome secretion pathway.
Ostrowski M, Carmo NB, Krumeich S, Fanget I, Raposo G, Savina A, Moita CF, Schauer K, Hume AN, Freitas RP, Goud B, Benaroch P, Hacohen N, Fukuda M, Desnos C, Seabra MC, Darchen F, Amigorena S, Moita LF, Thery C. Ostrowski M, et al. Nat Cell Biol. 2010 Jan;12(1):19-30; sup pp 1-13. doi: 10.1038/ncb2000. Epub 2009 Dec 6. Nat Cell Biol. 2010. PMID: 19966785 Free article.
Using an RNA interference (RNAi) screen, we identified five Rab GTPases that promote exosome secretion in HeLa cells. Among these, Rab27a and Rab27b were found to function in MVE docking at the plasma membrane. The size of MVEs was strongly increased by Rab27a silen …
Using an RNA interference (RNAi) screen, we identified five Rab GTPases that promote exosome secretion in HeLa cells. Among these, Rab27a …
KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a.
Song L, Tang S, Han X, Jiang Z, Dong L, Liu C, Liang X, Dong J, Qiu C, Wang Y, Du Y. Song L, et al. Nat Commun. 2019 Apr 9;10(1):1639. doi: 10.1038/s41467-019-09720-x. Nat Commun. 2019. PMID: 30967557 Free PMC article.
Comparing protein profiles between KIBRA knockout and wild-type mouse brain showed significantly decreased Rab27a, a small GTPase that regulates MVB-PM docking. Rab27a is stabilized by interacting with KIBRA, which prevents ubiquitination and degradation via the ubi …
Comparing protein profiles between KIBRA knockout and wild-type mouse brain showed significantly decreased Rab27a, a small GTPase tha …
Rab27a, actin and beta-cell endocytosis.
Kimura T, Niki I. Kimura T, et al. Endocr J. 2011;58(1):1-6. doi: 10.1507/endocrj.k10e-391. Epub 2010 Dec 23. Endocr J. 2011. PMID: 21187662 Free article. Review.
GTP-Rab27a and its specific effectors are responsible for this process like other GTPases. Recently, we searched for Rab27a-interacting proteins and identified coronin 3. Unexpectedly, coronin 3 only bound GDP-Rab27a and this interaction regulated post-exocyt …
GTP-Rab27a and its specific effectors are responsible for this process like other GTPases. Recently, we searched for Rab27a-in …
Rab27a in pancreatic beta-cells, a busy protein in membrane trafficking.
Kimura T, Niki I. Kimura T, et al. Prog Biophys Mol Biol. 2011 Nov;107(2):219-23. doi: 10.1016/j.pbiomolbio.2011.06.016. Epub 2011 Jul 7. Prog Biophys Mol Biol. 2011. PMID: 21762718 Review.
In pancreatic beta-cells, Rab27a controls pre-exocytotic stages of insulin secretion. A few GTP-dependent Rab27a effectors are known to mediate these cellular functions. We recently found that Rab27a also possesses the GDP-dependent effector coronin 3. Coroni …
In pancreatic beta-cells, Rab27a controls pre-exocytotic stages of insulin secretion. A few GTP-dependent Rab27a effectors are …
Rab3A/Rab27A System Silencing Ameliorates High Glucose-Induced Injury in Podocytes.
Martinez-Arroyo O, Flores-Chova A, Sanchez-Garcia B, Redon J, Cortes R, Ortega A. Martinez-Arroyo O, et al. Biology (Basel). 2023 May 9;12(5):690. doi: 10.3390/biology12050690. Biology (Basel). 2023. PMID: 37237503 Free PMC article.
Intra- and intercellular communication through exosomes are key processes for maintaining function, and the Rab3A/Rab27A system is an important counterpart. Previously, we observed significant changes in the Rab3A/Rab27A system in podocytes under glucose overload, d …
Intra- and intercellular communication through exosomes are key processes for maintaining function, and the Rab3A/Rab27A system is an …
RAB27A promotes the proliferation and invasion of colorectal cancer cells.
Li Q, Zhao H, Dong W, Guan N, Hu Y, Zeng Z, Zhang H, Zhang F, Li Q, Yang J, Xiao W. Li Q, et al. Sci Rep. 2022 Nov 12;12(1):19359. doi: 10.1038/s41598-022-23696-7. Sci Rep. 2022. PMID: 36371494 Free PMC article.
However, it is controversial for the role of RAB27A in CRC progression, so we explored the exact function of RAB27A in CRC development in this study. Based on the stable colon cancer cell lines of RAB27A knockdown and ectopic expression, we found that RAB2 …
However, it is controversial for the role of RAB27A in CRC progression, so we explored the exact function of RAB27A in CRC dev …
Interplay between Rab27a effectors in pancreatic beta-cells.
Yamaoka M, Ishizaki T, Kimura T. Yamaoka M, et al. World J Diabetes. 2015 Apr 15;6(3):508-16. doi: 10.4239/wjd.v6.i3.508. World J Diabetes. 2015. PMID: 25897360 Free PMC article. Review.
Rab27a has GTP- and GDP-bound forms, and their interconversion regulates intracellular signaling pathways. ...Glucose stimulation causes insulin exocytosis. Glucose stimulation also converts Rab27a from its GTP- to its GDP-bound form. GDP-bound Rab27a interac …
Rab27a has GTP- and GDP-bound forms, and their interconversion regulates intracellular signaling pathways. ...Glucose stimulation cau …
Rab27a-mediated exosome secretion in anterior cingulate cortex contributes to colorectal visceral pain in adult mice with neonatal maternal deprivation.
Sun Q, Weng RX, Li JH, Li YC, Xu JT, Li R, Lu X, Xu GY. Sun Q, et al. Am J Physiol Gastrointest Liver Physiol. 2023 Oct 1;325(4):G356-G367. doi: 10.1152/ajpgi.00029.2023. Epub 2023 Aug 2. Am J Physiol Gastrointest Liver Physiol. 2023. PMID: 37529842 Free article.
Injection of NMD-derived exosomes produced colorectal visceral pain in CON mice. Rab27a was upregulated in ACC of NMD mice. Rab27a was highly expressed in ACC neurons of NMD mice, rather than astrocytes and microglia. Injection of Rab27a-siRNA reduced the rel …
Injection of NMD-derived exosomes produced colorectal visceral pain in CON mice. Rab27a was upregulated in ACC of NMD mice. Rab27a …
The role of Rab27a in the regulation of neutrophil function.
Catz SD. Catz SD. Cell Microbiol. 2014 Sep;16(9):1301-10. doi: 10.1111/cmi.12328. Epub 2014 Aug 4. Cell Microbiol. 2014. PMID: 24964030 Review.
Regulation of granular trafficking, docking and fusion is at the core of the neutrophil defense response to pathogens. The small GTPase Rab27a has emerged as a central regulator of the neutrophil response through its tight control of vesicular trafficking and degranulation …
Regulation of granular trafficking, docking and fusion is at the core of the neutrophil defense response to pathogens. The small GTPase R …
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