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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1975 1
1977 1
1979 2
1980 2
1983 2
1984 2
1985 3
1986 2
1987 5
1988 5
1989 6
1990 8
1991 9
1992 11
1993 16
1994 8
1995 12
1996 20
1997 12
1998 24
1999 22
2000 15
2001 24
2002 27
2003 20
2004 24
2005 24
2006 29
2007 26
2008 38
2009 45
2010 43
2011 63
2012 74
2013 76
2014 79
2015 91
2016 110
2017 152
2018 132
2019 128
2020 132
2021 151
2022 154
2023 149
2024 78

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1,850 results

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Page 1
Reduce, replace, refine-Animal experiments.
Kirschner KM. Kirschner KM. Acta Physiol (Oxf). 2021 Nov;233(3):e13726. doi: 10.1111/apha.13726. Epub 2021 Aug 25. Acta Physiol (Oxf). 2021. PMID: 34418296 No abstract available.
Reduce, refine, replace.
[No authors listed] [No authors listed] Nat Immunol. 2010 Nov;11(11):971. doi: 10.1038/ni1110-971. Nat Immunol. 2010. PMID: 20959796
Refine, reduce, replace: Imaging of fibrosis and arthritis in animal models.
Marenzana M, Vande Velde G. Marenzana M, et al. Best Pract Res Clin Rheumatol. 2015 Dec;29(6):715-40. doi: 10.1016/j.berh.2016.02.001. Epub 2016 Mar 14. Best Pract Res Clin Rheumatol. 2015. PMID: 27107509 Review.
It provides evidence for the viability of this approach not only for ethical reasons (reducing numbers and suffering in research animals, according to the 3R principles) but also for accelerating experimental output and making it more translational. The emphasis is on prom …
It provides evidence for the viability of this approach not only for ethical reasons (reducing numbers and suffering in research anim …
Research on the Radiotoxicology of Plutonium Using Animals: Consideration of the 3Rs-Replace, Reduce, Refine.
Griffiths NM, Van der Meeren A, Angulo JF, Vincent-Naulleau S. Griffiths NM, et al. Health Phys. 2020 Jul;119(1):133-140. doi: 10.1097/HP.0000000000001258. Health Phys. 2020. PMID: 32301862 Review.
In recent years, the use of animals for scientific purposes has become a public concern. The application of the 3Rs - Replace (use of alternative methods or animals not considered capable of experiencing pain, suffering, and distress), Reduce (reduction in animal nu …
In recent years, the use of animals for scientific purposes has become a public concern. The application of the 3Rs - Replace (use of …
Key Opportunities to Replace, Reduce, and Refine Regulatory Fish Acute Toxicity Tests.
Burden N, Benstead R, Benyon K, Clook M, Green C, Handley J, Harper N, Maynard SK, Mead C, Pearson A, Ryder K, Sheahan D, van Egmond R, Wheeler JR, Hutchinson TH. Burden N, et al. Environ Toxicol Chem. 2020 Oct;39(10):2076-2089. doi: 10.1002/etc.4824. Epub 2020 Aug 24. Environ Toxicol Chem. 2020. PMID: 32681761 Free PMC article.
There is great scope to apply the 3Rs principles-the reduction, refinement, and replacement of animals-in this area of testing. An expert ecotoxicology working group, led by the UK National Centre for the Replacement, Refinement and Reduction of Animal …
There is great scope to apply the 3Rs principles-the reduction, refinement, and replacement of animals-in this area of testing …
Saturated fat, carbohydrate, and cardiovascular disease.
Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Siri-Tarino PW, et al. Am J Clin Nutr. 2010 Mar;91(3):502-9. doi: 10.3945/ajcn.2008.26285. Epub 2010 Jan 20. Am J Clin Nutr. 2010. PMID: 20089734 Free PMC article. Review.
However, the evidence that supports a reduction in saturated fat intake must be evaluated in the context of replacement by other macronutrients. Clinical trials that replaced saturated fat with polyunsaturated fat have generally shown a reduction in CVD events, alth …
However, the evidence that supports a reduction in saturated fat intake must be evaluated in the context of replacement by other macr …
Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association.
Sacks FM, Lichtenstein AH, Wu JHY, Appel LJ, Creager MA, Kris-Etherton PM, Miller M, Rimm EB, Rudel LL, Robinson JG, Stone NJ, Van Horn LV; American Heart Association. Sacks FM, et al. Circulation. 2017 Jul 18;136(3):e1-e23. doi: 10.1161/CIR.0000000000000510. Epub 2017 Jun 15. Circulation. 2017. PMID: 28620111 Review.
Cardiovascular disease (CVD) is the leading global cause of death, accounting for 17.3 million deaths per year. Preventive treatment that reduces CVD by even a small percentage can substantially reduce, nationally and globally, the number of people who develop CVD a …
Cardiovascular disease (CVD) is the leading global cause of death, accounting for 17.3 million deaths per year. Preventive treatment that …
Fetal Bovine Serum (FBS): Past - Present - Future.
van der Valk J, Bieback K, Buta C, Cochrane B, Dirks WG, Fu J, Hickman JJ, Hohensee C, Kolar R, Liebsch M, Pistollato F, Schulz M, Thieme D, Weber T, Wiest J, Winkler S, Gstraunthaler G. van der Valk J, et al. ALTEX. 2018;35(1):99-118. doi: 10.14573/altex.1705101. Epub 2017 Aug 9. ALTEX. 2018. PMID: 28800376 Free article.
Together with the above-mentioned challenges, several strategies have been developed to reduce or replace FBS in cell culture media in terms of the 3Rs (Refinement, Reduction, Replacement). ...
Together with the above-mentioned challenges, several strategies have been developed to reduce or replace FBS in cell culture …
1,850 results